Combined Approach to Leukemic Differentiation Using Transcription Factor PU.1-Enhancing Agents.
5-Azacytidine
Celastrol
microRNA miR-155
transcription factor PU.1
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
16 Jun 2022
16 Jun 2022
Historique:
received:
21
12
2021
revised:
13
06
2022
accepted:
14
06
2022
entrez:
24
6
2022
pubmed:
25
6
2022
medline:
28
6
2022
Statut:
epublish
Résumé
The transcription factor PU.1 (Purine-rich DNA binding, SPI1) is a key regulator of hematopoiesis, whose level is influenced by transcription through its enhancers and its post-transcriptional degradation via microRNA-155 (miR-155). The degree of transcriptional regulation of the
Identifiants
pubmed: 35743167
pii: ijms23126729
doi: 10.3390/ijms23126729
pmc: PMC9224232
pii:
doi:
Substances chimiques
MIRN155 microRNA, human
0
MicroRNAs
0
Proto-Oncogene Proteins
0
Trans-Activators
0
proto-oncogene protein Spi-1
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Czech Science Foundation
ID : 19-03586S
Organisme : Ministry of Health
ID : NV19-08-00144, NU21-08-00312
Organisme : Charles University
ID : GAUK 1672119 , SVV260521 , UNCE/MED/016 , Progres Q26
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