MCD Diet Rat Model Induces Alterations in Zinc and Iron during NAFLD Progression from Steatosis to Steatohepatitis.
Fe
MMPs
NAFLD
NASH
RECK
Zn
iron
liver
steatohepatitis
steatosis
zinc
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 Jun 2022
19 Jun 2022
Historique:
received:
30
05
2022
revised:
15
06
2022
accepted:
17
06
2022
entrez:
24
6
2022
pubmed:
25
6
2022
medline:
28
6
2022
Statut:
epublish
Résumé
We evaluate the effects of the methionine-choline-deficient (MCD) diet on serum and hepatic zinc (Zn) and iron (Fe) and their relationships with matrix metalloproteinases (MMPs) and their modulators (TIMPs and RECK) as well as hepatic fatty acids using male Wistar rats fed 2-, 4- and 8-week MCD diets. Serum and hepatic Zn decrease after an 8-week MCD diet. Serum Fe increases after an 8-week MCD diet and the same occurs for hepatic Fe. An increase in hepatic MMP activity, associated with a decrease in RECK and TIMPs, is found in the MCD 8-week group. Liver Fe shows a positive correlation versus MMPs and RECK, and an inverse correlation versus TIMPs. A positive correlation is found comparing liver Zn with stearic, vaccenic and arachidonic acids, and an inverse correlation is found with linolenic and docosatetraenoic acids. An opposite trend is found between liver Fe versus these fatty acids. During NAFLD progression from steatosis to steatohepatitis, MCD rats exhibit an increase in Zn and a decrease in Fe levels both in serum and tissue associated with alterations in hepatic MMPs and their inhibitors, and fatty acids. The correlations detected between Zn and Fe versus extracellular matrix modulators and fatty acids support their potential role as therapeutic targets.
Identifiants
pubmed: 35743260
pii: ijms23126817
doi: 10.3390/ijms23126817
pmc: PMC9224179
pii:
doi:
Substances chimiques
Fatty Acids
0
Methionine
AE28F7PNPL
Iron
E1UOL152H7
Zinc
J41CSQ7QDS
Choline
N91BDP6H0X
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Nutrients. 2017 Jun 17;9(6):
pubmed: 28629136
Hepatol Res. 2009 Mar;39(3):213-22
pubmed: 19261002
Dis Model Mech. 2014 Feb;7(2):193-203
pubmed: 24713275
Clin Nutr. 2006 Oct;25(5):816-23
pubmed: 16677739
Biomed Res Int. 2014;2014:327537
pubmed: 25013773
N Engl J Med. 2000 Nov 16;343(20):1467-76
pubmed: 11078773
Proc Natl Acad Sci U S A. 2012 May 29;109(22):8517-22
pubmed: 22586114
Metabol Open. 2021 Jun 29;11:100105
pubmed: 34337376
Endocr Rev. 1997 Dec;18(6):801-31
pubmed: 9408744
Nat Rev Microbiol. 2013 Jun;11(6):371-84
pubmed: 23669886
Semin Liver Dis. 1996 Feb;16(1):13-30
pubmed: 8723320
J Nutr Metab. 2017;2017:4798963
pubmed: 28465837
Int J Vitam Nutr Res. 2019 Jul;89(1-2):62-72
pubmed: 30957704
Hepatology. 2004 Mar;39(3):608-16
pubmed: 14999679
World J Gastroenterol. 2016 Sep 28;22(36):8112-22
pubmed: 27688653
Liver Int. 2006 Dec;26(10):1258-67
pubmed: 17105592
JPEN J Parenter Enteral Nutr. 2001 Sep-Oct;25(5):260-8
pubmed: 11531217
J Biol Chem. 2010 Jun 11;285(24):18528-36
pubmed: 20395294
Hepatology. 2016 Jul;64(1):73-84
pubmed: 26707365
World J Gastroenterol. 2012 Sep 14;18(34):4651-8
pubmed: 23002334
Eur J Gastroenterol Hepatol. 2020 Jun;32(6):748-753
pubmed: 31688305
Clin Liver Dis. 2008 Nov;12(4):759-68, viii
pubmed: 18984465
Antioxid Redox Signal. 2010 Jun 1;12(11):1295-331
pubmed: 19803748
Medicina (Kaunas). 2019 Jan 24;55(2):
pubmed: 30682878
J Hepatol. 2016 Jun;64(6):1388-402
pubmed: 27062661
Nutrients. 2018 Jan 14;10(1):
pubmed: 29342898
Cell Metab. 2015 Jul 7;22(1):138-50
pubmed: 26028554
J Alzheimers Dis. 2009;16(4):715-29
pubmed: 19387108
Digestion. 2015;92(3):130-7
pubmed: 26329758
Am J Gastroenterol. 2001 Aug;96(8):2448-55
pubmed: 11513189
Proc Natl Acad Sci U S A. 2005 May 10;102(19):6843-8
pubmed: 15863613
Biochim Biophys Acta Mol Basis Dis. 2019 May 1;1865(5):943-953
pubmed: 29990551
Sci Rep. 2019 Nov 14;9(1):16810
pubmed: 31728041
J Biol Chem. 1996 May 31;271(22):12964-71
pubmed: 8662699
BMC Endocr Disord. 2009 Feb 25;9:7
pubmed: 19243577
Front Pharmacol. 2020 Dec 03;11:603926
pubmed: 33343375
Molecules. 2022 Jan 27;27(3):
pubmed: 35164140
FEBS Lett. 1995 May 1;364(1):28-32
pubmed: 7750537
Clin Exp Pharmacol Physiol. 2015 Jun;42(6):695-703
pubmed: 25904005
Biol Trace Elem Res. 1996 Aug;54(2):173-83
pubmed: 8886317
J Hepatol. 2011 Oct;55(4):920-32
pubmed: 21718726
J Clin Invest. 2005 Feb;115(2):209-18
pubmed: 15690074
Biomolecules. 2020 Jul 31;10(8):
pubmed: 32751983
Asia Pac J Clin Nutr. 2021 Dec;30(4):704-714
pubmed: 34967199
Biol Trace Elem Res. 2019 Apr;188(2):326-333
pubmed: 30014284
Liver Int. 2007 Feb;27(1):120-7
pubmed: 17241390
Health Promot Perspect. 2018 Jul 07;8(3):187-194
pubmed: 30087841
Biogerontology. 2006 Oct-Dec;7(5-6):449-59
pubmed: 16967203
PLoS One. 2020 Sep 10;15(9):e0238543
pubmed: 32911524
Biomed Res Int. 2014;2014:803491
pubmed: 25006587
J Gastroenterol Hepatol. 2008 Dec;23(12):1909-16
pubmed: 18422963
Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13612-7
pubmed: 16950869
Arch Pathol. 1964 Jul;78:69-72
pubmed: 14150734
PLoS One. 2015 May 27;10(5):e0127991
pubmed: 26017539
J Pathol. 2017 Jan;241(1):36-44
pubmed: 27757953
J Hepatol. 2004 Jan;40(1):47-51
pubmed: 14672613
Biochem Pharmacol. 2002 Oct 1;64(7):1139-45
pubmed: 12234617
Arch Med Res. 2014 Feb;45(2):116-24
pubmed: 24480733
Histol Histopathol. 2008 Aug;23(8):1003-10
pubmed: 18498076
Biochim Biophys Acta. 2005 Apr 15;1740(1):60-7
pubmed: 15878742
Cell Mol Gastroenterol Hepatol. 2018 Aug 23;6(4):451-462
pubmed: 30294653
Clin Obes. 2022 Aug;12(4):e12525
pubmed: 35412016
Methods Enzymol. 1990;186:407-21
pubmed: 2233308
Biol Trace Elem Res. 2015 Dec;168(2):411-20
pubmed: 25987270
J Lipid Res. 2008 Jun;49(6):1187-94
pubmed: 18204095
J Biol Chem. 1951 Nov;193(1):265-75
pubmed: 14907713
Lipids Health Dis. 2021 Jul 28;20(1):78
pubmed: 34320998
Gastroenterology. 1998 Feb;114(2):311-8
pubmed: 9453491
Clin Sci (Lond). 2012 Sep;123(5):323-32
pubmed: 22439844