What Role Does
PDGFA
gene
platelet-rich plasma
single nucleotide polymorphisms
tendinopathy
tennis elbow
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
17 Jun 2022
17 Jun 2022
Historique:
received:
19
04
2022
revised:
04
06
2022
accepted:
16
06
2022
entrez:
24
6
2022
pubmed:
25
6
2022
medline:
25
6
2022
Statut:
epublish
Résumé
This study aims to identify genotype variants of the platelet-derived growth factor alpha polypeptide gene ( We observed a cohort of 107 patients (132 elbows) with tennis elbow who received treatment with PRP. Patients have been followed-up for two years after PRP injection and the effectiveness of the treatment was measured using universal patient-reported outcome measures (PROMs): visual analog scale (VAS), quick version of disabilities of the arm, shoulder and hand score (QDASH), and patient-rated tennis elbow evaluation (PRTEE). PROMs values, and clinical and platelet parameters were compared between genotype variants of the studied polymorphisms (rs1800814, rs2070958 and rs62433334). The A allele carriers (rs1800814) had significantly lower values of VAS (week 12), QDASH, and PRTEE (weeks 8, 12). The T allele carriers (rs2070958) had significantly lower values of VAS (weeks 8, 12), QDASH, and PRTEE (weeks 4-12). Additional forms of therapy (manual and physical) were necessary significantly more often in GG (rs1800814) and CC (rs2070958) homozygotes. The
Sections du résumé
BACKGROUND
BACKGROUND
This study aims to identify genotype variants of the platelet-derived growth factor alpha polypeptide gene (
METHODS
METHODS
We observed a cohort of 107 patients (132 elbows) with tennis elbow who received treatment with PRP. Patients have been followed-up for two years after PRP injection and the effectiveness of the treatment was measured using universal patient-reported outcome measures (PROMs): visual analog scale (VAS), quick version of disabilities of the arm, shoulder and hand score (QDASH), and patient-rated tennis elbow evaluation (PRTEE). PROMs values, and clinical and platelet parameters were compared between genotype variants of the studied polymorphisms (rs1800814, rs2070958 and rs62433334).
RESULTS
RESULTS
The A allele carriers (rs1800814) had significantly lower values of VAS (week 12), QDASH, and PRTEE (weeks 8, 12). The T allele carriers (rs2070958) had significantly lower values of VAS (weeks 8, 12), QDASH, and PRTEE (weeks 4-12). Additional forms of therapy (manual and physical) were necessary significantly more often in GG (rs1800814) and CC (rs2070958) homozygotes.
CONCLUSIONS
CONCLUSIONS
The
Identifiants
pubmed: 35743573
pii: jcm11123504
doi: 10.3390/jcm11123504
pmc: PMC9224593
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Medical University of Silesia
ID : PCN-1-071/K/0/Z
Organisme : Medical University of Silesia
ID : PCN-1-096/K/1/Z
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