Magnetic Nanoclusters Increase the Sensitivity of Lateral Flow Immunoassays for Protein Detection: Application to Pneumolysin as a Biomarker for
COVID-19
inductive sensor
lateral flow immunoassays
magnetic nanoparticles
magnetic separation
pneumococcal pneumonia
Journal
Nanomaterials (Basel, Switzerland)
ISSN: 2079-4991
Titre abrégé: Nanomaterials (Basel)
Pays: Switzerland
ID NLM: 101610216
Informations de publication
Date de publication:
14 Jun 2022
14 Jun 2022
Historique:
received:
10
05
2022
revised:
07
06
2022
accepted:
08
06
2022
entrez:
24
6
2022
pubmed:
25
6
2022
medline:
25
6
2022
Statut:
epublish
Résumé
Lateral flow immunoassays for detecting biomarkers in body fluids are simple, quick, inexpensive point-of-care tests widely used in disease surveillance, such as during the coronavirus disease 2019 (COVID-19) pandemic. Improvements in sensitivity would increase their utility in healthcare, food safety, and environmental control. Recently, biofunctional magnetic nanoclusters have been used to selectively label target proteins, which allows their detection and quantification with a magneto-inductive sensor. This type of detector is easily integrated with the lateral flow immunoassay format. Pneumolysin is a cholesterol-dependent cytolysin and one of the most important protein virulence factors of pneumonia produced by
Identifiants
pubmed: 35745381
pii: nano12122044
doi: 10.3390/nano12122044
pmc: PMC9228753
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Spanish Ministry of Economy and Competitiveness
ID : MCI-20-EIN2020-112354
Organisme : Gobierno del Principado de Asturias
ID : FICYT/IDI/2021/000100
Organisme : Gobierno del Principado de Asturias
ID : FICYT/IDI/2021/000273
Organisme : Consejería de Educación y Cultura del Gobierno del Principado de Asturias
ID : BP19-141
Organisme : University of Oviedo, the Ministry of Education, Culture and Sport, and Banco Santander
ID : CEI15-24
Organisme : University Technological Institute of Asturias (IUTA)
ID : SV-21-GIJON-03
Organisme : Romanian Ministry of Research and Innovation
ID : Core Project PN-19-35-02-03
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