Novel High-Throughput Fluorescence-Based Assay for the Identification of Nematocidal Compounds That Target the Blood-Feeding Pathway.
blood-feeding
drug-screening
fluorescence
helminth
hookworm
motility
viability
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
27 May 2022
27 May 2022
Historique:
received:
26
04
2022
revised:
23
05
2022
accepted:
24
05
2022
entrez:
24
6
2022
pubmed:
25
6
2022
medline:
25
6
2022
Statut:
epublish
Résumé
Hookworm infections cause a neglected tropical disease (NTD) affecting ~740 million people worldwide, principally those living in disadvantaged communities. Infections can cause high morbidity due to their impact on nutrient uptake and their need to feed on host blood, resulting in a loss of iron and protein, which can lead to severe anaemia and impaired cognitive development in children. Currently, only one drug, albendazole is efficient to treat hookworm infection and the scientific community fears the rise of resistant strains. As part of on-going efforts to control hookworm infections and its associated morbidities, new drugs are urgently needed. We focused on targeting the blood-feeding pathway, which is essential to the parasite survival and reproduction, using the laboratory hookworm model
Identifiants
pubmed: 35745589
pii: ph15060669
doi: 10.3390/ph15060669
pmc: PMC9231213
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Swiss National Science Foundation
ID : PR00P3_193084
Pays : Switzerland
Organisme : European Society of Clinical Microbiology and Infectious Diseases
ID : Research Grant 2017
Organisme : Swiss National Science Foundation
ID : national project NCCR-Chemical Biology
Pays : Switzerland
Organisme : National Health and Medical Research Council
ID : National Health and Medical Research Council (NHMRC) SRF-B
Organisme : Australian Research Council
ID : LP180101085
Organisme : Australian Research Council
ID : LP190101209
Organisme : Australian Research Council
ID : DP210101500
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