Bacterial Cellulose-Adaptation of a Nature-Identical Material to the Needs of Advanced Chronic Wound Care.

advanced wound care bacterial cellulose carbohydrate polymer chronic wounds clinical data exudate management moisture vapor transmission rate

Journal

Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453

Informations de publication

Date de publication:
30 May 2022
Historique:
received: 24 04 2022
revised: 19 05 2022
accepted: 21 05 2022
entrez: 24 6 2022
pubmed: 25 6 2022
medline: 25 6 2022
Statut: epublish

Résumé

Modern wound treatment calls for hydroactive dressings. Among the variety of materials that have entered the field of wound care in recent years, the carbohydrate polymer bacterial cellulose (BC) represents one of the most promising candidates as the biomaterial features a high moisture-loading and donation capacity, mechanical stability, moldability, and breathability. Although BC has already gained increasing relevance in the treatment of burn wounds, its potential and clinical performance for "chronic wound" indications have not yet been sufficiently investigated. This article focuses on experimental and clinical data regarding the application of BC within the indications of chronic, non-healing wounds, especially venous and diabetic ulcers. A recent clinical observation study in a chronic wound setting clearly demonstrated its wound-cleansing properties and ability to induce healing in stalling wounds. Furthermore, the material parameters of BC dressings obtained through the static cultivation of

Identifiants

pubmed: 35745602
pii: ph15060683
doi: 10.3390/ph15060683
pmc: PMC9228795
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : The Free State of Thuringia and the European Social Fund
ID : INP0046
Organisme : European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement
ID : 955335

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Auteurs

Paul Zahel (P)

JeNaCell GmbH-An Evonik Company, 07745 Jena, Germany.
Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, 07743 Jena, Germany.

Uwe Beekmann (U)

JeNaCell GmbH-An Evonik Company, 07745 Jena, Germany.

Thomas Eberlein (T)

Akademie-ZWM AG, 8424 Embrach, Switzerland.

Michael Schmitz (M)

MCS Medical Consulting, 56414 Oberahr, Germany.

Oliver Werz (O)

Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, 07743 Jena, Germany.

Dana Kralisch (D)

JeNaCell GmbH-An Evonik Company, 07745 Jena, Germany.
Evonik Operations GmbH, 45128 Essen, Germany.

Classifications MeSH