Protocetraric and Salazinic Acids as Potential Inhibitors of SARS-CoV-2 3CL Protease: Biochemical, Cytotoxic, and Computational Characterization of Depsidones as Slow-Binding Inactivators.

SARS-CoV-2 3CL protease cysteine enzyme inactivator inhibition assay lichen secondary metabolites slow binding inhibitor

Journal

Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453

Informations de publication

Date de publication:
04 Jun 2022
Historique:
received: 16 05 2022
revised: 01 06 2022
accepted: 02 06 2022
entrez: 24 6 2022
pubmed: 25 6 2022
medline: 25 6 2022
Statut: epublish

Résumé

The study investigated the inhibitory activity of protocetraric and salazinic acids against SARS-CoV-2 3CL

Identifiants

pubmed: 35745633
pii: ph15060714
doi: 10.3390/ph15060714
pmc: PMC9227325
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Lorenza Fagnani (L)

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio 1, 67100 L'Aquila, Italy.

Lisaurora Nazzicone (L)

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio 1, 67100 L'Aquila, Italy.

Pierangelo Bellio (P)

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio 1, 67100 L'Aquila, Italy.

Nicola Franceschini (N)

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio 1, 67100 L'Aquila, Italy.

Donatella Tondi (D)

Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy.

Andrea Verri (A)

Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy.

Sabrina Petricca (S)

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio 1, 67100 L'Aquila, Italy.

Roberto Iorio (R)

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio 1, 67100 L'Aquila, Italy.

Gianfranco Amicosante (G)

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio 1, 67100 L'Aquila, Italy.

Mariagrazia Perilli (M)

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio 1, 67100 L'Aquila, Italy.

Giuseppe Celenza (G)

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio 1, 67100 L'Aquila, Italy.

Classifications MeSH