Combination of Photodynamic Therapy and Oral Antifungals for the Treatment of Onychomycosis.
onychomycosis
oral antifungals
photodynamic therapy
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
07 Jun 2022
07 Jun 2022
Historique:
received:
29
04
2022
revised:
24
05
2022
accepted:
01
06
2022
entrez:
24
6
2022
pubmed:
25
6
2022
medline:
25
6
2022
Statut:
epublish
Résumé
Onychomycosis accounts for 50% of nail disorders, making it one of the most prevalent fungal diseases and a therapeutic challenge. Photodynamic therapy (PDT) could constitute a therapeutic alternative, owing to its good adherence, the low probability of resistance, the lack of interaction with antimicrobials, and its favorable adverse effect profile. This retrospective observational study included all patients with a microbiological diagnosis of onychomycosis treated with PDT at Miguel Servet University Hospital, Zaragoza (Spain), between January 2013 and June 2021. The protocol consisted of pre-treatment with 40% urea for 7 days, followed by 16% methyl-aminolevulinate (MAL) for 3 h and subsequent irradiation with a red-light LED lamp (37 J/cm
Identifiants
pubmed: 35745641
pii: ph15060722
doi: 10.3390/ph15060722
pmc: PMC9227606
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
J Photochem Photobiol B. 2015 Sep;150:66-8
pubmed: 25835504
Acta Derm Venereol. 2010 Mar;90(2):216-7
pubmed: 20169321
Mycoses. 2005 Mar;48(2):101-7
pubmed: 15743426
Arch Dermatol. 2002 Mar;138(3):353-7
pubmed: 11902986
J Am Acad Dermatol. 2010 Mar;62(3):411-4
pubmed: 20159308
J Eur Acad Dermatol Venereol. 2015 Jul;29(7):1275-9
pubmed: 25589056
Photodermatol Photoimmunol Photomed. 2021 May;37(3):183-191
pubmed: 33145834
Dermatol Ther. 2020 Nov;33(6):e14280
pubmed: 32890444
Mycoses. 2020 Jun;63(6):558-565
pubmed: 32187409
J Cutan Med Surg. 2004 Jan-Feb;8(1):25-30
pubmed: 15688097
J Biophotonics. 2021 Jan;14(1):e202000340
pubmed: 33058451
N Engl J Med. 2009 May 14;360(20):2108-16
pubmed: 19439745
An Bras Dermatol. 2014 Jan-Feb;89(1):184-6
pubmed: 24626676
Dermatology. 2010;220(2):164-8
pubmed: 20110639
Dermatol Ther. 2014 Jan-Feb;27(1):43-7
pubmed: 24502311
J Eur Acad Dermatol Venereol. 2017 Feb;31(2):347-354
pubmed: 27515478
Photodiagnosis Photodyn Ther. 2020 Sep;31:101774
pubmed: 32339671
Pharmaceuticals (Basel). 2019 Mar 23;12(1):
pubmed: 30909531
Am J Clin Dermatol. 2000 Jan-Feb;1(1):19-26
pubmed: 11702301
Actas Dermosifiliogr. 2015 Dec;106(10):795-805
pubmed: 26427737
Mycoses. 2021 Jul;64(7):694-700
pubmed: 33539562