A Hybrid of Amodiaquine and Primaquine Linked by Gold(I) Is a Multistage Antimalarial Agent Targeting Heme Detoxification and Thiol Redox Homeostasis.
Plasmodium
antimalarial drugs
flavoenzymes
gold
heme detoxification
hemozoin
malaria
quinolines
redox homeostasis
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
12 Jun 2022
12 Jun 2022
Historique:
received:
04
05
2022
revised:
01
06
2022
accepted:
07
06
2022
entrez:
24
6
2022
pubmed:
25
6
2022
medline:
25
6
2022
Statut:
epublish
Résumé
Hybrid-based drugs linked through a transition metal constitute an emerging concept for
Identifiants
pubmed: 35745823
pii: pharmaceutics14061251
doi: 10.3390/pharmaceutics14061251
pmc: PMC9229949
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Fondazione Cariplo
ID : 2017-0846
Organisme : Fundação para a Ciência e Tecnologia
ID : INF- 29550-2017
Organisme : Délégation Générale pour l'Armement
ID : PDH-2-NRBC-4-B-4104
Organisme : National Council for Scientific and Technological Development
ID : 306009/2020-0; 305732/2019-6
Organisme : Coordenação de Aperfeicoamento de Pessoal de Nível Superior
ID : 001
Organisme : Santé Publique France
ID : CNR du Paludisme
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : PRIN 2015.4JRJPP_004
Organisme : Fundação de Amparo à Pesquisa do Estado de Minas Gerais
ID : APQ-01543-18
Organisme : Oswaldo Cruz Foundation
ID : IGM-002-FIO-20-2-25
Organisme : Fundação de Amparo à Pesquisa do Estado da Bahia
ID : APP0088/2016
Organisme : NIAID NIH HHS
ID : R33 AI127635
Pays : United States
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