The Benefits of Vaccination against SARS-CoV-2 during Pregnancy in Favor of the Mother/Newborn Dyad.

COVID-19 SARS-CoV-2 antibodies breastfeeding newborn pregnancy spike protein vaccination

Journal

Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355

Informations de publication

Date de publication:
26 May 2022
Historique:
received: 20 04 2022
revised: 16 05 2022
accepted: 24 05 2022
entrez: 24 6 2022
pubmed: 25 6 2022
medline: 25 6 2022
Statut: epublish

Résumé

When the first vaccines against SARS-CoV-2 emerged, pregnant women were excluded from clinical trials, so vaccine recommendations were initially adjourned, with late initiation for this populational category. The present study aims to quantify the serum and breastmilk values of SARS-CoV-2 spike protein antibodies in both the mother and her newborn after complete vaccination during pregnancy. Ninety-one vaccinated patients were included, some of whom presented COVID-19 infection during pregnancy. In the delivery room, venous blood was collected from the mother and umbilical cord blood from her offspring. All samples were processed using the ECLIA (electrochemiluminescence) method. Breastmilk was collected and tested during the third postnatal day. The highest maternal serum values were 19,523 U/mL (detection limit > 0.8 U/mL) and in breastmilk, 206.7 U/mL. Every single newborn had antibody values higher than 0, with a mean serum value (M = 5288.37, SD = 5661.49) significantly higher than 0, t(90) = 8.91, p < 0.001. Consequently, this study intents to emphasize the importance of vaccination against SARS-CoV-2 during pregnancy. This double kind of neonatal protection, attained by placental and breastmilk transfer, can be accomplished by encouraging vaccination, breastfeeding, bonding, and providing maternal empowerment to participate in her infant’s care.

Identifiants

pubmed: 35746456
pii: vaccines10060848
doi: 10.3390/vaccines10060848
pmc: PMC9228905
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Daniela-Eugenia Popescu (DE)

Department of Obstetrics-Gynecology and Neonatology, "Victor Babeș" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Department of Neonatology, Premiere Hospital, Regina Maria Health Network, 300645 Timisoara, Romania.

Cosmin Cîtu (C)

Department of Obstetrics-Gynecology and Neonatology, "Victor Babeș" University of Medicine and Pharmacy, 300041 Timisoara, Romania.

Ana Maria Cristina Jura (AMC)

Department of Neonatology, "Louis Țurcanu" Children Emergency Clinical Hospital Timișoara, 300011 Timisoara, Romania.

Nicoleta Lungu (N)

Department of Obstetrics-Gynecology and Neonatology, "Victor Babeș" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Department of Neonatology, "Louis Țurcanu" Children Emergency Clinical Hospital Timișoara, 300011 Timisoara, Romania.

Dan Navolan (D)

Department of Obstetrics-Gynecology and Neonatology, "Victor Babeș" University of Medicine and Pharmacy, 300041 Timisoara, Romania.

Marius Craina (M)

Department of Obstetrics-Gynecology and Neonatology, "Victor Babeș" University of Medicine and Pharmacy, 300041 Timisoara, Romania.

Alin Semenescu (A)

Institute for Advanced Environmental Research (ICAM), West University of Timisoara, 300223 Timisoara, Romania.

Florin Gorun (F)

Department of Obstetrics-Gynecology and Neonatology, "Victor Babeș" University of Medicine and Pharmacy, 300041 Timisoara, Romania.

Mihai-Andrei Jura (MA)

Department of Epidemiology, "Pius Brinzeu" Emergency County Hospital Timisoara, 300736 Timisoara, Romania.

Valerica Belengeanu (V)

Department of Genetics, Institute of Life Science, Faculty of Medicine, "Vasile Goldiş" Western University of Arad, 310025 Arad, Romania.

Marioara Boia (M)

Department of Obstetrics-Gynecology and Neonatology, "Victor Babeș" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Department of Neonatology, "Louis Țurcanu" Children Emergency Clinical Hospital Timișoara, 300011 Timisoara, Romania.

Classifications MeSH