Increasing Uptake of COVID-19 Vaccination and Reducing Health Inequalities in Patients on Renal Replacement Therapy-Experience from a Single Tertiary Centre.

COVID-19 vaccination ethnicity haemodialysis health inequalities kidney transplant peritoneal dialysis social deprivation

Journal

Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355

Informations de publication

Date de publication:
13 Jun 2022
Historique:
received: 04 05 2022
revised: 28 05 2022
accepted: 07 06 2022
entrez: 24 6 2022
pubmed: 25 6 2022
medline: 25 6 2022
Statut: epublish

Résumé

COVID-19 vaccination has changed the landscape of the COVID-19 pandemic; however, decreased uptake due to vaccine hesitancy has been observed, particularly in patients from minority ethnic backgrounds and socially deprived areas. These patient characteristics are common in patients on Renal Replacement Therapy (RRT), a population at extremely high risk of developing serious illness from COVID-19 and who would thus benefit the most from the vaccination programme. We designed a bespoke COVID-19 vaccination programme for our RRT population with the aim of decreasing health inequalities and increasing vaccination uptake. Key interventions included addressing vaccine hesitancy by deploying the respective clinical teams as trusted messengers, prompt eligible patient identification and notification, the deployment of resources to optimise vaccine administration in a manner convenient to patients, and the timely collection and analysis of local safety and efficacy data. First, COVID-19 vaccination data in relation to ethnicity and social deprivation in our RRT population, measured by the multiple deprivation index, were analysed and compared to uptake data in the total regional adult clinically extremely vulnerable (CEV) population in Greater Manchester (GM). Univariate logistic regression analysis was used to explore the factors associated with not receiving a vaccine. Out of 1156 RRT patients included in this analysis, 96.7% received the first dose of the vaccination compared to 93% in the cohort of CEV patients in the GM. Age, gender, ethnicity, and a lower index of multiple deprivation were not identified as significant risk factors for poor first dose vaccine uptake in our cohort. Vaccine uptake in Asian and Black RRT patients was 94.9% and 92.3%, respectively, compared to 93% and 76.2% for the same ethnic groups in the reference CEV GM. Vaccine uptake was 96.1% for RRT patients in the lowest quartile of the multiple deprivation index, compared to 90.5% in the GM reference population. Bespoke COVID-19 vaccination programmes based on local clinical teams as trusted messengers can improve negative attitudes towards vaccination and reduce health inequalities.

Sections du résumé

BACKGROUND BACKGROUND
COVID-19 vaccination has changed the landscape of the COVID-19 pandemic; however, decreased uptake due to vaccine hesitancy has been observed, particularly in patients from minority ethnic backgrounds and socially deprived areas. These patient characteristics are common in patients on Renal Replacement Therapy (RRT), a population at extremely high risk of developing serious illness from COVID-19 and who would thus benefit the most from the vaccination programme. We designed a bespoke COVID-19 vaccination programme for our RRT population with the aim of decreasing health inequalities and increasing vaccination uptake.
METHODS METHODS
Key interventions included addressing vaccine hesitancy by deploying the respective clinical teams as trusted messengers, prompt eligible patient identification and notification, the deployment of resources to optimise vaccine administration in a manner convenient to patients, and the timely collection and analysis of local safety and efficacy data. First, COVID-19 vaccination data in relation to ethnicity and social deprivation in our RRT population, measured by the multiple deprivation index, were analysed and compared to uptake data in the total regional adult clinically extremely vulnerable (CEV) population in Greater Manchester (GM). Univariate logistic regression analysis was used to explore the factors associated with not receiving a vaccine.
RESULTS RESULTS
Out of 1156 RRT patients included in this analysis, 96.7% received the first dose of the vaccination compared to 93% in the cohort of CEV patients in the GM. Age, gender, ethnicity, and a lower index of multiple deprivation were not identified as significant risk factors for poor first dose vaccine uptake in our cohort. Vaccine uptake in Asian and Black RRT patients was 94.9% and 92.3%, respectively, compared to 93% and 76.2% for the same ethnic groups in the reference CEV GM. Vaccine uptake was 96.1% for RRT patients in the lowest quartile of the multiple deprivation index, compared to 90.5% in the GM reference population.
CONCLUSION CONCLUSIONS
Bespoke COVID-19 vaccination programmes based on local clinical teams as trusted messengers can improve negative attitudes towards vaccination and reduce health inequalities.

Identifiants

pubmed: 35746547
pii: vaccines10060939
doi: 10.3390/vaccines10060939
pmc: PMC9231261
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Dimitrios Poulikakos (D)

Department of Renal Medicine, Northern Care Alliance NHS Foundation Trust, Salford M6 8HD, UK.
Faculty of Biology, Medicine, and Health, University of Manchester, Manchester M13 9PL, UK.

Rajkumar Chinnadurai (R)

Department of Renal Medicine, Northern Care Alliance NHS Foundation Trust, Salford M6 8HD, UK.
Faculty of Biology, Medicine, and Health, University of Manchester, Manchester M13 9PL, UK.

Saira Anwar (S)

Faculty of Biology, Medicine, and Health, University of Manchester, Manchester M13 9PL, UK.

Amnah Ahmed (A)

Faculty of Biology, Medicine, and Health, University of Manchester, Manchester M13 9PL, UK.

Chukwuma Chukwu (C)

Department of Renal Medicine, Northern Care Alliance NHS Foundation Trust, Salford M6 8HD, UK.
Faculty of Biology, Medicine, and Health, University of Manchester, Manchester M13 9PL, UK.

Jayne Moore (J)

Department of Renal Medicine, Northern Care Alliance NHS Foundation Trust, Salford M6 8HD, UK.

Emma Hayes (E)

Department of Renal Medicine, Northern Care Alliance NHS Foundation Trust, Salford M6 8HD, UK.

Julie Gorton (J)

Department of Renal Medicine, Northern Care Alliance NHS Foundation Trust, Salford M6 8HD, UK.

David Lewis (D)

Department of Renal Medicine, Northern Care Alliance NHS Foundation Trust, Salford M6 8HD, UK.

Rosie Donne (R)

Department of Renal Medicine, Northern Care Alliance NHS Foundation Trust, Salford M6 8HD, UK.
Faculty of Biology, Medicine, and Health, University of Manchester, Manchester M13 9PL, UK.

Elizabeth Lamerton (E)

Department of Renal Medicine, Northern Care Alliance NHS Foundation Trust, Salford M6 8HD, UK.

Rachel Middleton (R)

Department of Renal Medicine, Northern Care Alliance NHS Foundation Trust, Salford M6 8HD, UK.
Faculty of Biology, Medicine, and Health, University of Manchester, Manchester M13 9PL, UK.

Edmond O'Riordan (E)

Department of Renal Medicine, Northern Care Alliance NHS Foundation Trust, Salford M6 8HD, UK.

Classifications MeSH