DOACs for stroke prevention in patients with AF and cancer.

atrial fibrillation cancer direct oral anticoagulants (DOACs)

Journal

The British journal of cardiology
ISSN: 1753-4313
Titre abrégé: Br J Cardiol
Pays: England
ID NLM: 9503762

Informations de publication

Date de publication:
2020
Historique:
entrez: 24 6 2022
pubmed: 2 12 2020
medline: 2 12 2020
Statut: epublish

Résumé

Stroke prophylaxis in atrial fibrillation is an important consideration in patients with cancer. However, there is little consensus on the choice of anticoagulation, due to the numerous difficulties associated with active cancer. Direct oral anticoagulants (DOACs) have been shown to be a promising option. Here, we conduct a simple cross-sectional analysis of 29 cancer patients receiving DOACs for stroke prophylaxis in atrial fibrillation at a tertiary-care institution in London. Our study demonstrates an encouraging efficacy and safety profile of DOACs used in this setting. We conclude by suggesting that, while DOACs may be useful, anticoagulation in cancer patients should continue to be individualised.

Identifiants

pubmed: 35747222
doi: 10.5837/bjc.2020.036
pii: bjc.2020.036
pmc: PMC9205240
doi:

Types de publication

Journal Article

Langues

eng

Pagination

36

Informations de copyright

Copyright © 2020 Medinews (Cardiology) Limited.

Déclaration de conflit d'intérêts

None declared.

Références

J Am Heart Assoc. 2018 Aug 21;7(16):e008987
pubmed: 30369307
J Am Coll Cardiol. 2018 Oct 16;72(16):1913-1922
pubmed: 30309468
J Thromb Haemost. 2019 Aug;17(8):1247-1252
pubmed: 31207027
Blood Adv. 2018 Feb 13;2(3):200-209
pubmed: 29378726
J Am Coll Cardiol. 2019 Mar 26;73(11):1336-1349
pubmed: 30898209

Auteurs

Dipal Mehta (D)

Clinical Haematology, Barts Cancer Centre, St. Bartholomew's Hospital, Barts Health NHS Trust, London, EC1A 7BE.

Daniel M Jones (DM)

Cardiology, Barts Cancer Centre, St. Bartholomew's Hospital, Barts Health NHS Trust, London, EC1A 7BE.

Avirup Guha (A)

Assistant Professor in Cardiology, Harrington Heart and Vascular Institute, Case Western Reserve University, Cleveland, OH 44106 USA.

Peter K MacCallum (PK)

Consultant Haematologist, Thrombosis Service, Barts Health NHS Trust, London, EC1A 7BE.

Amitava Banerjee (A)

Honorary Consultant Cardiologist, Institute of Health Informatics, University College London and Barts Health NHS Trust, London, EC1A 7BE.

Charlotte Manisty (C)

Consultant Cardiologist, Cardio-Oncology Service, Barts Heart Centre, St. Bartholomew's Hospital, Barts Health NHS Trust, London, EC1A 7BE.

Thomas Crake (T)

Consultant Cardiologist, Cardio-Oncology Service, Barts Heart Centre, St. Bartholomew's Hospital, Barts Health NHS Trust, London, EC1A 7BE.

Mark Westwood (M)

Consultant Cardiologist, Cardio-Oncology Service, Barts Heart Centre, St. Bartholomew's Hospital, Barts Health NHS Trust, London, EC1A 7BE.

Arjun K Ghosh (AK)

Consultant Cardiologist, Cardio-Oncology Service, Barts Heart Centre, St. Bartholomew's Hospital, Barts Health NHS Trust, London, EC1A 7BE.

Classifications MeSH