Low titer Group O whole blood utilization in pediatric trauma resuscitation: A National Survey.
children
pediatric
transfusion
trauma
whole blood
Journal
Transfusion
ISSN: 1537-2995
Titre abrégé: Transfusion
Pays: United States
ID NLM: 0417360
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
revised:
12
01
2022
received:
06
12
2021
accepted:
21
01
2022
pubmed:
25
6
2022
medline:
30
7
2022
entrez:
24
6
2022
Statut:
ppublish
Résumé
Renewed interest in low titer group O whole blood (LTOWB) transfusion has led to increased utilization in adult trauma centers; little is known regarding LTOWB use in pediatric centers. A survey of LTOWB utilization at American pediatric level 1 trauma centers. Responses were received from 43/72 (60%) centers. These institutions were primarily urban (84%) and pediatric-specific (58%). There were 16% (7/43) centers using LTOWB, 7% (3/43) imminently initiating an LTOWB program, 47% (20/43) with interest but no current plan to develop a LTOWB program, and 30% (13/43) with no immediate interest in an LTOWB program. For the hospitals actively or imminently using LTOWB, 70% (3/10) have a minimum recipient weight criterion, 60% (6/10) have a minimum age criterion, and 70% (7/10) restrict the maximum volume transfused. Before the patient's RhD type becomes known, 30% (3/10) use RhD negative LTOWB for males and females, 40% (4/10) use RhD positive LTOWB for males and RhD negative LTOWB for females, 20% (2/10) use RhD positive LTOWB for males and RhD negative RBCs for females, and 10% (1/10) use RhD positive LTOWB for both males and females. Maximum LTOWB storage duration was 14-35 days and units nearing expiration were used for non-trauma patients (40%), processed to RBC (40%), and/or discarded (40%). The most common barriers to implementation were concerns about inventory management (37%), wastage (35%), infrequent use (33%), cost (21%) and unclear efficacy (14%). LTOWB utilization is increasing in pediatric level 1 trauma centers in the United States.
Sections du résumé
BACKGROUND
Renewed interest in low titer group O whole blood (LTOWB) transfusion has led to increased utilization in adult trauma centers; little is known regarding LTOWB use in pediatric centers.
STUDY DESIGN AND METHODS
A survey of LTOWB utilization at American pediatric level 1 trauma centers.
RESULTS
Responses were received from 43/72 (60%) centers. These institutions were primarily urban (84%) and pediatric-specific (58%). There were 16% (7/43) centers using LTOWB, 7% (3/43) imminently initiating an LTOWB program, 47% (20/43) with interest but no current plan to develop a LTOWB program, and 30% (13/43) with no immediate interest in an LTOWB program. For the hospitals actively or imminently using LTOWB, 70% (3/10) have a minimum recipient weight criterion, 60% (6/10) have a minimum age criterion, and 70% (7/10) restrict the maximum volume transfused. Before the patient's RhD type becomes known, 30% (3/10) use RhD negative LTOWB for males and females, 40% (4/10) use RhD positive LTOWB for males and RhD negative LTOWB for females, 20% (2/10) use RhD positive LTOWB for males and RhD negative RBCs for females, and 10% (1/10) use RhD positive LTOWB for both males and females. Maximum LTOWB storage duration was 14-35 days and units nearing expiration were used for non-trauma patients (40%), processed to RBC (40%), and/or discarded (40%). The most common barriers to implementation were concerns about inventory management (37%), wastage (35%), infrequent use (33%), cost (21%) and unclear efficacy (14%).
CONCLUSION
LTOWB utilization is increasing in pediatric level 1 trauma centers in the United States.
Substances chimiques
ABO Blood-Group System
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
S63-S71Informations de copyright
© 2022 AABB.
Références
Zielinski MD, Jenkins DH, Hughes JD, Badjie KSW, Stubbs JR. Back to the future: the renaissance of whole-blood transfusions for massively hemorrhaging patients. J Surg Res. 2014;155:883-6.
Leibner E, Andreae M, Galvagno SM, Scalea T. Damage control resuscitation. Clin Exp Emerg Med. 2020;7:5-13.
Holcomb JB, Jenkins D, Rhee P, Johannigman J, Mahoney P, Mehta S, et al. Damage control resuscitation: directly addressing the early coagulopathy of trauma. J Trauma. 2007;62:307-10.
Van PY, Holcomb JB, Schreiber MA. Novel concepts for damage control resuscitation in trauma. Curr Opin Crit Care. 2017;23:498-502.
Cannon JW, Khan MA, Raja AS, Cohen MJ, Como JJ, Cotton BA, et al. Damage control resuscitation in patients with severe traumatic hemorrhage: a practice management guideline from the eastern Association for the Surgery of trauma. J Trauma Acute Care Surg. 2017;82:605-17.
Cap AP, Pidcoke HF, Spinella P, Strandenes G, Borgman MA, Schreiber M, et al. Damage control resuscitation. Mil Med. 2018;183:36-43.
Hanna K, Bible L, Chehab M, Asmar S, Douglas M, Ditillo M, et al. Nationwide analysis of whole blood hemostatic resuscitation in civilian trauma. J Trauma Acute Care Surg. 2020;89:329-35.
Yazer MH, Cap AP, Spinella PC. Raising the standards on whole blood. J Trauma Acute Care Surg. 2018;84:S14-s7.
Kornblith LZ, Howard BM, Cheung CK, Dayter Y, Pandey S, Busch MP, et al. The whole is greater than the sum of its parts: hemostatic profiles of whole blood variants. J Trauma Acute Care Surg. 2014;77:818-27.
Manno CS, Hedberg KW, Kim HC, Bunin GR, Nicolson S, Jobes D, et al. Comparison of the hemostatic effects of fresh whole blood, stored whole blood, and components after open heart surgery in children. Blood. 1991;77:930-6.
Becker GA, Tuccelli M, Kunicki T, Chalos MK, Aster RH. Studies of platelet concentrates stored at 22 C nad 4 C. Transfusion. 1973;13:61-8.
Braathen H, Sivertsen J, Lunde THF, Kristoffersen EK, Assmus J, Hervig TA, et al. In vitro quality and platelet function of cold and delayed cold storage of apheresis platelet concentrates in platelet additive solution for 21 days. Transfusion. 2019;59:2652-61.
Reddoch-Cardenas KM, Peltier GC, Chance TC, Nair PM, Meledeo MA, Ramasubramanian AK, et al. Cold storage of platelets in platelet additive solution maintains mitochondrial integrity by limiting initiation of apoptosis-mediated pathways. Transfusion. 2021;61:178-90.
Getz TM, Montgomery RK, Bynum JA, Aden JK, Pidcoke HF, Cap AP. Storage of platelets at 4°C in platelet additive solutions prevents aggregate formation and preserves platelet functional responses. Transfusion. 2016;56:1320-8.
Jobes D, Wolfe Y, O'Neill D, Calder J, Jones L, Sesok-Pizzini D, et al. Toward a definition of "fresh" whole blood: an in vitro characterization of coagulation properties in refrigerated whole blood for transfusion. Transfusion. 2011;51:43-51.
Montgomery RK, Reddoch KM, Evani SJ, Cap AP, Ramasubramanian AK. Enhanced shear-induced platelet aggregation due to low-temperature storage. Transfusion. 2013;53:1520-30.
Reddoch-Cardenas KM, Bynum JA, Meledeo MA, Nair PM, Wu X, Darlington DN, et al. Cold-stored platelets: a product with function optimized for hemorrhage control. Transfus Apher Sci. 2019;58:16-22.
Matthay ZA, Hellmann ZJ, Callcut RA, Matthay EC, Nunez-Garcia B, Duong W, et al. Outcomes after ultramassive transfusion in the modern era: an eastern Association for the Surgery of trauma multicenter study. J Trauma Acute Care Surg. 2021;91:24-33.
Spinella PC, Pidcoke HF, Strandenes G, Hervig T, Fisher A, Jenkins D, et al. Whole blood for hemostatic resuscitation of major bleeding. Transfusion. 2016;56(Suppl 2):S190-202.
Dishong D, Cap AP, Holcomb JB, Triulzi DJ, Yazer MH. The rebirth of the cool: a narrative review of the clinical outcomes of cold stored low titer group O whole blood recipients compared to conventional component recipients in trauma. Hematology. 2021;26:601-11.
Seheult JN, Bahr MP, Spinella PC, Triulzi DJ, Yazer MH. The Dead Sea needs salt water… massively bleeding patients need whole blood: the evolution of blood product resuscitation. Transfus Clin Biol. 2019;26:174-9.
Harrold IM, Seheult JN, Alarcon LH, Corcos A, Sperry JL, Triulzi DJ, et al. Hemolytic markers following the transfusion of uncrossmatched, cold-stored, low-titer, group O+ whole blood in civilian trauma patients. Transfusion. 2020;60(3):S24-30.
Yazer MH, Freeman A, Harrold IM, Anto V, Neal MD, Triulzi DJ, et al. Injured recipients of low titer group O whole blood have similar clinical outcomes compared to recipients of conventional component therapy: a single-center, retrospective study. Transfusion. 2021;61:1710-20.
Seheult JN, Bahr M, Anto V, Alarcon LH, Corcos A, Sperry JL, et al. Safety profile of uncrossmatched, cold-stored, low-titer, group O+ whole blood in civilian trauma patients. Transfusion. 2018;58:2280-8.
Yazer MH, Seheult JN, Beckett A, Triulzi DJ, Spinella PC. Rebirth of the cool: the modern renaissance of low titer group O whole blood for treating massively bleeding civilian patients. Annals of. Blood. 2021;7. https://doi.org/10.21037/aob-21-34
Schaefer R, Long T, Wampler D, Summers R, Epley E, Waltman E, et al. Operationalizing the deployment of low-titer O-positive whole blood within a regional trauma system. Mil Med. 2021;186:391-9.
Morgan KM, Yazer MH, Triulzi DJ, Strotmeyer S, Gaines BA, Leeper CM. Safety profile of low-titer group O whole blood in pediatric patients with massive hemorrhage. Transfusion. 2021;61(Suppl 1):S8-s14.
Cotton BA, Podbielski J, Camp E, Welch T, del Junco D, Bai Y, et al. A randomized controlled pilot trial of modified whole blood versus component therapy in severely injured patients requiring large volume transfusions. Ann Surg. 2013;258:527-32. discussion 32-3.
Gallaher JR, Dixon A, Cockcroft A, Grey M, Dewey E, Goodman A, et al. Large volume transfusion with whole blood is safe compared with component therapy. J Trauma Acute Care Surg. 2020;89:238-45.
Williams J, Merutka N, Meyer D, Bai Y, Prater S, Cabrera R, et al. Safety profile and impact of low-titer group O whole blood for emergency use in trauma. J Trauma Acute Care Surg. 2020;88:87-93.
Duchesne J, Smith A, Lawicki S, Hunt J, Houghton A, Taghavi S, et al. Single institution trial comparing whole blood vs balanced component therapy: 50 years later. J Am Coll Surg. 2021;232:433-42.
Leeper CM, Yazer MH, Triulzi DJ, Neal MD, Gaines BA. Whole blood is superior to component transfusion for injured children: a propensity matched analysis. Ann Surg. 2020;272:590-4.
Anand T, Obaid O, Nelson A, Chehab M, Ditillo M, Hammad A, et al. Whole blood hemostatic resuscitation in pediatric trauma: a nationwide propensity-matched analysis. J Trauma Acute Care Surg. 2021;91:573-8.
Shea SM, Staudt A, Thomas KA, et al. The use of low-titer Group O whole blood is independently associated with improved survival compared to component therapy in adults with severe traumatic hemorrhage. Transfusion. 2020;60:S2-9.
Hazelton JP, Cannon JW, Zatorski C, Roman JS, Moore SA, Young AJ, et al. Cold-stored whole blood: a better method of trauma resuscitation? J Trauma Acute Care Surg. 2019;87:1035-41.
Yazer MH, Spinella PC. An international survey on the use of low titer group O whole blood for the resuscitation of civilian trauma patients in 2020. Transfusion. 2020;30:S176-S9.
Yazer MH, Spinella PC, Anto V, Dunbar NM. Suvey of group a plasma and low-titer group O whole blood use in trauma resuscitation at adult civilian level 1 trauma centers in the US. Transfusion. 2021;61:1757-63.
Yazer MH, Spinella PC. The use of low-titer group O whole blood for the resuscitation of civilian trauma patients in 2018. Transfusion. 2018;58:2744-6.
Yazer MH, Spinella PC. Review of low titer group O whole blood use for massively bleeding patients around the world in 2019. ISBT Sci Ser. 2019;14:276-81.
Zhu CS, Pokorny DM, Eastridge BJ, Nicholson SE, Epley E, Forcum J, et al. Give the trauma patient what they bleed, when and where they need it: establishing a comprehensive regional system of resuscitation based on patient need utilizing cold-stored, low-titer O+ whole blood. Transfusion. 2019;59:1429-38.
Zielinski MD, Stubbs JR, Berns KS, Glassberg E, Murdock AD, Shinar E, et al. Prehospital blood transfusion programs: capabilities and lessons learned. J Trauma Acute Care Surg. 2017;82:S70-S8.
Shroyer MC, Griffin RL, Mortellaro VE, Russell RT. Massive transfusion in pediatric trauma: analysis of the National Trauma Databank. J Surg Res. 2017;208:166-72.
Leonard JC, Josephson CD, Luther JF, Wisniewski SR, Allen C, Chiusolo F, et al. Life-threatening bleeding in children: a prospective observational Study. Crit Care Med. 2021;49:1943-54.
Holcomb JB, del Junco DJ, Fox EE, Wade CE, Cohen MJ, Schreiber MA, et al. The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks. JAMA Surg. 2013;148:127-36.
Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, et al. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial. JAMA. 2015;313:471-82.
Leeper CM, Yazer MH, Cladis FP, Saladino R, Triulzi DJ, Gaines BA. Use of Uncrossmatched cold-stored whole blood in injured children with hemorrhagic shock. JAMA Pediatr. 2018;172:491-2.
Leeper CM, Yazer MH, Morgan KM, Triulzi DJ, Gaines BA. Adverse events after low titer group O whole blood versus component product transfusion in pediatric trauma patients: a propensity-matched cohort study. Transfusion. 2021;61:2621-8.
Gaines BA, Yazer MH, Triulzi DJ, Sperry JL, Neal MD, Billiar TR, et al. Low titer Group O whole blood in injured children requiring massive transfusion. Ann Surg. 2021. https://doi.org/10.1097/SLA.0000000000005251. Epub ahead of print.
Yazer MH, Dunbar NM, Delaney M. Survey of the RhD selection and issuing practices for uncrossmatched blood products at pediatric trauma hospitals in the United States: the BEST collaborative study. Transfusion. 2021;61:3328-34.
Yazer MH, Spinella PC, Seheult JN. Risk of future haemolytic disease of the fetus and newborn following the transfusion of Rh(D)-positive blood products to Rh(D)-negative children. Vox Sang. 2021;117:291-2.
Leeper CM, McKenna C, Gaines BA. Too little too late: hypotension and blood transfusion in the trauma bay are independent predictors of death in injured children. J Trauma Acute Care Surg. 2018;85:674-8.
Hervig TA, Doughty HA, Cardigan RA, Apelseth TO, Hess JR, Noorman F, et al. Re-introducing whole blood for transfusion: considerations for blood providers. Vox Sang. 2021;116:167-74.