Maternal antibiotics disrupt microbiome, behavior, and temperature regulation in unexposed infant mice.
dysbiosis
metabolism
microbiome
mouse model
social development
thermoregulation
Journal
Developmental psychobiology
ISSN: 1098-2302
Titre abrégé: Dev Psychobiol
Pays: United States
ID NLM: 0164074
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
revised:
21
04
2022
received:
07
03
2022
accepted:
12
05
2022
entrez:
24
6
2022
pubmed:
25
6
2022
medline:
29
6
2022
Statut:
ppublish
Résumé
Maternal antibiotic (ABx) exposure can significantly perturb the transfer of microbiota from mother to offspring, resulting in dysbiosis of potential relevance to neurodevelopmental disorders such as autism spectrum disorder (ASD). Studies in rodent models have found long-term neurobehavioral effects in offspring of ABx-treated dams, but ASD-relevant behavior during the early preweaning period has thus far been neglected. Here, we exposed C57BL/6J mouse dams to ABx (5 mg/ml neomycin, 1.25 μg/ml pimaricin, .075% v/v acetic acid) dissolved in drinking water from gestational day 12 through offspring postnatal day 14. A number of ASD-relevant behaviors were assayed in offspring, including ultrasonic vocalization (USV) production during maternal separation, group huddling in response to cold challenge, and olfactory-guided home orientation. In addition, we obtained measures of thermoregulatory competence in pups during and following behavioral testing. We found a number of behavioral differences in offspring of ABx-treated dams (e.g., modulation of USVs by pup weight, activity while huddling) and provide evidence that some of these behavioral effects can be related to thermoregulatory deficiencies, particularly at younger ages. Our results suggest not only that ABx can disrupt microbiomes, thermoregulation, and behavior, but that metabolic effects may confound the interpretation of behavioral differences observed after early-life ABx exposure.
Identifiants
pubmed: 35748626
doi: 10.1002/dev.22289
pmc: PMC9236156
mid: NIHMS1808582
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e22289Subventions
Organisme : NICHD NIH HHS
ID : R01 HD082203
Pays : United States
Organisme : NICHD NIH HHS
ID : R21 HD083769
Pays : United States
Informations de copyright
© 2022 Wiley Periodicals LLC.
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