"Ependymal-in" Gradient of Thalamic Damage in Progressive Multiple Sclerosis.


Journal

Annals of neurology
ISSN: 1531-8249
Titre abrégé: Ann Neurol
Pays: United States
ID NLM: 7707449

Informations de publication

Date de publication:
10 2022
Historique:
revised: 17 06 2022
received: 08 11 2021
accepted: 22 06 2022
pubmed: 25 6 2022
medline: 21 9 2022
entrez: 24 6 2022
Statut: ppublish

Résumé

Leptomeningeal and perivenular infiltrates are important contributors to cortical grey matter damage and disease progression in multiple sclerosis (MS). Whereas perivenular inflammation induces vasculocentric lesions, leptomeningeal involvement follows a subpial "surface-in" gradient. To determine whether similar gradient of damage occurs in deep grey matter nuclei, we examined the dorsomedial thalamic nuclei and cerebrospinal fluid (CSF) samples from 41 postmortem secondary progressive MS cases compared with 5 non-neurological controls and 12 controls with other neurological diseases. CSF/ependyma-oriented gradient of reduction in NeuN

Identifiants

pubmed: 35748636
doi: 10.1002/ana.26448
pmc: PMC9796378
doi:

Substances chimiques

Parvalbumins 0
Receptors, Tumor Necrosis Factor, Type I 0
Chitinases EC 3.2.1.14

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

670-685

Informations de copyright

© 2022 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

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Auteurs

Roberta Magliozzi (R)

Neurology Section of Department of Neurological and Movement Sciences, University of Verona, Verona, Italy.
Department of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK.

Giulia Fadda (G)

Center for Neuroinflammation and Experimental Therapeutics and the Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Robert A Brown (RA)

ShadowLab Research Inc., Toronto, Ontario, Canada.

Amit Bar-Or (A)

Center for Neuroinflammation and Experimental Therapeutics and the Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Owain W Howell (OW)

Department of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK.
Institute of Life Sciences, Swansea University, Swansea, UK.

Simon Hametner (S)

Brain Research Center, Medical University of Vienna, Vienna, Austria.

Damiano Marastoni (D)

Neurology Section of Department of Neurological and Movement Sciences, University of Verona, Verona, Italy.

Alberto Poli (A)

Neurology Section of Department of Neurological and Movement Sciences, University of Verona, Verona, Italy.

Richard Nicholas (R)

Department of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK.

Massimiliano Calabrese (M)

Neurology Section of Department of Neurological and Movement Sciences, University of Verona, Verona, Italy.

Salvatore Monaco (S)

Neurology Section of Department of Neurological and Movement Sciences, University of Verona, Verona, Italy.

Richard Reynolds (R)

Department of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK.
Centre for Molecular Neuropathology, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

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