Sex and cancer immunotherapy: Current understanding and challenges.

Humans Immunity Immunotherapy Neoplasms / pathology

Journal

Cancer cell
ISSN: 1878-3686
Titre abrégé: Cancer Cell
Pays: United States
ID NLM: 101130617

Informations de publication

Date de publication:
11 07 2022
Historique:
pubmed: 25 6 2022
medline: 15 7 2022
entrez: 24 6 2022
Statut: ppublish

Résumé

Recent evidence highlights patients' sex relevance in antitumor immune response through a complex interaction-among hormones, genes, behaviors, and the microbiome-that affects both innate and adaptive immune functions, as well as immune evasion mechanisms. These complex interactions ultimately influence the efficacy and toxicity of immune checkpoint inhibitors in solid tumors.

Identifiants

DOI: 10.1016/j.ccell.2022.06.005 PMID: 35750053
pubmed: 35750053
pii: S1535-6108(22)00269-0
doi: 10.1016/j.ccell.2022.06.005
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

695-700

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Laura Pala (L)

Division of Melanoma, Sarcomas and Rare Tumors, European Institute of Oncology, Milan, Italy.

Tommaso De Pas (T)

Division of Melanoma, Sarcomas and Rare Tumors, European Institute of Oncology, Milan, Italy.

Chiara Catania (C)

Division of Thoracic Oncology, European Institute of Oncology, IRCCS, Milan, Italy.

Giuseppe Giaccone (G)

Meyer Cancer Center, Weill Cornel Medicine, New York, NY, USA.

Alberto Mantovani (A)

Humanitas Clinical and Research Center, IRCCS, Rozzano, Italy; Humanitas University, Pieve Emanuele, Italy; William Harvey Research Institute, Queen Mary University, London, UK.

Saverio Minucci (S)

Department of Experimental Oncology, European Institute of Oncology, IRCCS, Milan, Italy; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

Giuseppe Viale (G)

Department of Pathology, European Institute of Oncology, Milan, Italy; University of Milan, Milan, Italy.

Richard D Gelber (RD)

Department of Data Science, Dana-Farber Cancer Institute, Harvard Medical School, Harvard T.H. Chan School of Public Health, and Frontier Science Foundation, Boston, MA, USA.

Fabio Conforti (F)

Division of Melanoma, Sarcomas and Rare Tumors, European Institute of Oncology, Milan, Italy. Electronic address: fabio.conforti@ieo.it.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Sex and cancer immunotherapy: Current...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Sex and cancer immunotherapy: Current...
questionsmedicales.fr › Thérapeutique › Biothérapie › Immunothérapie › Sex and cancer immunotherapy: Current...
questionsmedicales.fr › Tumeurs › Sex and cancer immunotherapy: Current...