Kidney organoids: a pioneering model for kidney diseases.
Journal
Translational research : the journal of laboratory and clinical medicine
ISSN: 1878-1810
Titre abrégé: Transl Res
Pays: United States
ID NLM: 101280339
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
11
04
2022
revised:
14
06
2022
accepted:
16
06
2022
pubmed:
25
6
2022
medline:
24
11
2022
entrez:
24
6
2022
Statut:
ppublish
Résumé
The kidney is a vital organ that regulates the bodily fluid and electrolyte homeostasis via tailored urinary excretion. Kidney injuries that cause severe or progressive chronic kidney disease have driven the growing population of patients with end-stage kidney disease, leading to substantial patient morbidity and mortality. This irreversible kidney damage has also created a huge socioeconomical burden on the healthcare system, highlighting the need for novel translational research models for progressive kidney diseases. Conventional research methods such as in vitro 2D cell culture or animal models do not fully recapitulate complex human kidney diseases. By contrast, directed differentiation of human induced pluripotent stem cells enables in vitro generation of patient-specific 3D kidney organoids, which can be used to model acute or chronic forms of hereditary, developmental, and metabolic kidney diseases. Furthermore, when combined with biofabrication techniques, organoids can be used as building blocks to construct vascularized kidney tissues mimicking their in vivo counterpart. By applying gene editing technology, organoid building blocks may be modified to minimize the process of immune rejection in kidney transplant recipients. In the foreseeable future, the universal kidney organoids derived from HLA-edited/deleted induced pluripotent stem cell (iPSC) lines may enable the supply of bioengineered organotypic kidney structures that are immune-compatible for the majority of the world population. Here, we summarize recent advances in kidney organoid research coupled with novel technologies such as organoids-on-chip and biofabrication of 3D kidney tissues providing convenient platforms for high-throughput drug screening, disease modelling, and therapeutic applications.
Identifiants
pubmed: 35750295
pii: S1931-5244(22)00146-3
doi: 10.1016/j.trsl.2022.06.012
pmc: PMC9691572
mid: NIHMS1836446
pii:
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-17Subventions
Organisme : NIBIB NIH HHS
ID : U01 EB028899
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC2 DK126023
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NCATS NIH HHS
ID : UH3 TR002155
Pays : United States
Organisme : NIDDK NIH HHS
ID : DP2 DK133821
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK127587
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Références
Function (Oxf). 2021 May 10;2(4):zqab026
pubmed: 35330622
Nat Mater. 2017 Nov;16(11):1112-1119
pubmed: 28967916
Development. 2005 Jul;132(13):2931-42
pubmed: 15944185
Genesis. 2007 Jul;45(7):432-9
pubmed: 17610272
JAMA. 2005 Aug 17;294(7):813-8
pubmed: 16106006
Pediatr Nephrol. 2011 Sep;26(9):1529-33
pubmed: 21604189
Cell Stem Cell. 2019 Sep 5;25(3):373-387.e9
pubmed: 31303547
Organogenesis. 2011 Apr-Jun;7(2):83-7
pubmed: 21386662
Am J Physiol Renal Physiol. 2018 Jul 1;315(1):F161-F172
pubmed: 29384415
Science. 2010 Aug 13;329(5993):841-5
pubmed: 20647424
Cell Stem Cell. 2008 Mar 6;2(3):284-91
pubmed: 18371453
Nat Biotechnol. 2015 Nov;33(11):1193-200
pubmed: 26458176
Dev Biol. 2013 Nov 1;383(1):52-60
pubmed: 24016758
Biofabrication. 2019 Nov 27;12(1):015010
pubmed: 31577996
Lab Chip. 2021 Feb 9;21(3):473-488
pubmed: 33480945
Kidney Int. 2010 Mar;77(5):407-16
pubmed: 20016472
Clin J Am Soc Nephrol. 2015 Apr 7;10(4):592-600
pubmed: 25635037
Sci Rep. 2015 Aug 17;5:13110
pubmed: 26279307
Nat Commun. 2022 Apr 28;13(1):2317
pubmed: 35484146
J Immunol. 2020 Jul 1;205(1):3-11
pubmed: 32571979
Nat Biotechnol. 2010 May;28(5):478-85
pubmed: 20458318
Front Immunol. 2021 Jan 21;11:624547
pubmed: 33552089
Nature. 2021 Jan;589(7841):281-286
pubmed: 33176333
Genes Dev. 2019 Oct 1;33(19-20):1319-1345
pubmed: 31575677
Nephrol Dial Transplant. 2013 Oct;28(10):2438-46
pubmed: 23625970
Dev Cell. 2019 Jul 1;50(1):102-116.e6
pubmed: 31265809
Cell Stem Cell. 2014 Jan 2;14(1):53-67
pubmed: 24332837
Kidney Int. 2015 Oct;88(4):684-90
pubmed: 26154924
Clin J Am Soc Nephrol. 2020 Mar 6;15(3):430-438
pubmed: 32066593
Nat Commun. 2022 Feb 1;13(1):611
pubmed: 35105870
Stem Cell Reports. 2018 Mar 13;10(3):766-779
pubmed: 29429961
Cell Stem Cell. 2018 Dec 6;23(6):869-881.e8
pubmed: 30449713
Cell. 2016 Jun 16;165(7):1586-1597
pubmed: 27315476
Nature. 2015 Oct 22;526(7574):564-8
pubmed: 26444236
Front Immunol. 2018 Aug 24;9:1910
pubmed: 30197643
J Am Soc Nephrol. 2018 Jul;29(7):1979-1991
pubmed: 29752413
Sci Adv. 2019 Sep 06;5(9):eaaw2459
pubmed: 31523707
J Am Soc Nephrol. 2022 May;33(5):889-907
pubmed: 35232775
Front Immunol. 2020 Jan 23;10:3060
pubmed: 32038617
Dev Cell. 2012 Jun 12;22(6):1191-207
pubmed: 22698282
Stem Cell Reports. 2018 Mar 13;10(3):751-765
pubmed: 29503086
Sci Rep. 2016 May 31;6:26715
pubmed: 27242131
Biomaterials. 2016 Dec;110:45-59
pubmed: 27710832
Am J Physiol Renal Physiol. 2019 Jul 1;317(1):F77-F89
pubmed: 31017008
Xenotransplantation. 2022 May;29(3):e12748
pubmed: 35616243
Dev Biol. 2021 Sep;477:98-116
pubmed: 34000274
Proc Natl Acad Sci U S A. 2021 Jul 27;118(30):
pubmed: 34301886
J Am Soc Nephrol. 2003 Jun;14(6):1523-34
pubmed: 12761253
Cold Spring Harb Perspect Biol. 2017 Mar 1;9(3):
pubmed: 27793968
Sci Adv. 2020 Jul 24;6(30):eabb5460
pubmed: 32754639
Nat Rev Nephrol. 2019 Oct;15(10):613-624
pubmed: 31383997
Dev Cell. 2005 Aug;9(2):283-92
pubmed: 16054034
Nat Mater. 2019 Apr;18(4):397-405
pubmed: 30778227
Nat Cell Biol. 2014 Jan;16(1):118-26
pubmed: 24335651
Physiology (Bethesda). 2017 Jul;32(4):266-277
pubmed: 28615311
Am J Transplant. 2012 Oct;12(10):2575-87
pubmed: 22900886
J Am Soc Nephrol. 2018 Jun;29(6):1690-1705
pubmed: 29739813
Development. 2019 Jun 12;146(12):
pubmed: 31118232
J Am Soc Nephrol. 2020 May;31(5):921-929
pubmed: 32354986
Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):12980-5
pubmed: 26392557
Am J Physiol. 1966 Jun;210(6):1293-8
pubmed: 5923067
J Am Soc Nephrol. 2013 May;24(6):906-16
pubmed: 23539760
Ren Fail. 1996 Nov;18(6):899-909
pubmed: 8948524
Am J Hum Genet. 2018 May 3;102(5):816-831
pubmed: 29706353
Transplantation. 2016 May;100(5):1094-102
pubmed: 26901078
Sci Transl Med. 2022 Mar 2;14(634):eabj4772
pubmed: 35235339
Eur Med J Reprod Health. 2017 Aug;3(1):57-67
pubmed: 31157117
J Am Soc Nephrol. 2012 Nov;23(11):1857-68
pubmed: 23085631
Kidney Int. 2007 Jun;71(12):1205-14
pubmed: 17410103
N Engl J Med. 2022 May 19;386(20):1889-1898
pubmed: 35584156
PLoS One. 2016 Jul 06;11(7):e0158765
pubmed: 27383068
Nat Rev Immunol. 2007 Jul;7(7):519-31
pubmed: 17571072
Nat Rev Nephrol. 2013 Oct;9(10):587-98
pubmed: 23999399
Dev Cell. 2010 May 18;18(5):698-712
pubmed: 20493806
Nat Rev Nephrol. 2019 Feb;15(2):87-108
pubmed: 30607032
Curr Opin Nephrol Hypertens. 2005 May;14(3):211-6
pubmed: 15821412
Proc Natl Acad Sci U S A. 2019 May 21;116(21):10441-10446
pubmed: 31040209
Am J Transplant. 2017 Aug;17(8):2092-2102
pubmed: 28245084
Nano Converg. 2021 Nov 8;8(1):35
pubmed: 34748091
Semin Cell Dev Biol. 2014 Dec;36:39-49
pubmed: 25153928
Development. 2009 Dec;136(23):3863-74
pubmed: 19906853
Genome Med. 2022 Feb 22;14(1):19
pubmed: 35189942
Nat Mater. 2021 Feb;20(2):260-271
pubmed: 33230326
Biomaterials. 2020 Jan;229:119547
pubmed: 31710953
Dev Biol. 2008 Dec 1;324(1):88-98
pubmed: 18835385
Transplant Rev (Orlando). 2017 Jan;31(1):1-9
pubmed: 27847221
Nat Methods. 2019 Mar;16(3):255-262
pubmed: 30742039
J Mol Med (Berl). 2021 Apr;99(4):477-487
pubmed: 33034708
Nat Cell Biol. 2013 Dec;15(12):1507-15
pubmed: 24240476
Sci Adv. 2020 Mar 06;6(10):eaaw5111
pubmed: 32181332
Nature. 2016 Apr 28;532(7600):512-6
pubmed: 27096360
Nat Protoc. 2017 Jan;12(1):195-207
pubmed: 28005067
Nephrol Dial Transplant. 2011 Jul;26(7):2181-8
pubmed: 21115670
Nat Rev Nephrol. 2018 Sep;14(9):558-570
pubmed: 29985463
Am J Transplant. 2022 Apr;22(4):1037-1053
pubmed: 35049121
Nat Rev Immunol. 2020 May;20(5):279-293
pubmed: 31853049
Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3507-12
pubmed: 23401516
Development. 2011 Apr;138(7):1247-57
pubmed: 21350016
Nat Rev Dis Primers. 2018 Dec 6;4(1):50
pubmed: 30523303
Nat Commun. 2018 Dec 4;9(1):5167
pubmed: 30514835
Stem Cell Reports. 2018 Sep 11;11(3):727-740
pubmed: 30174315
Cell Stem Cell. 2019 Apr 4;24(4):566-578.e7
pubmed: 30853558
J Biol Chem. 2021 Sep;297(3):101079
pubmed: 34391780
Sci Rep. 2017 Jul 3;7(1):4554
pubmed: 28674456
An Acad Bras Cienc. 2019;91(suppl 1):e20170238
pubmed: 28876358
Nat Commun. 2015 Oct 23;6:8715
pubmed: 26493500
Semin Cell Dev Biol. 2022 Jul;127:68-76
pubmed: 34627669
J Am Soc Nephrol. 2013 May;24(6):873-6
pubmed: 23578945
J Biol Chem. 2002 Aug 23;277(34):30998-1004
pubmed: 12055200
Nephrology (Carlton). 2018 Sep;23(9):805-814
pubmed: 29575280
Nat Commun. 2021 Feb 2;12(1):753
pubmed: 33531489
Kidney Int. 2010 Jul;78(1):38-47
pubmed: 20393451
Nature. 2006 Aug 3;442(7102):568-71
pubmed: 16760928