The chromatin roots of abnormal splicing in autism.

Autism Spectrum Disorder / genetics Autistic Disorder / genetics Brain Chromatin / genetics Humans RNA Splicing / genetics
autism spectrum disorder chromatin pre-mRNA splicing splicing regulation

Journal

Trends in genetics : TIG
ISSN: 0168-9525
Titre abrégé: Trends Genet
Pays: England
ID NLM: 8507085

Informations de publication

Date de publication:
09 2022
Historique:
received: 24 03 2022
revised: 30 05 2022
accepted: 01 06 2022
pubmed: 25 6 2022
medline: 12 8 2022
entrez: 24 6 2022
Statut: ppublish

Résumé

Spatiotemporal gene expression drives neurodevelopment. Therefore, abnormal expression during development results in atypical brain function. Alterations in gene expression have been described in autism spectrum disorder (ASD). Here, we focus on one aspect of gene expression, pre-mRNA splicing, specifically, the mechanism of its regulation by chromatin and how this is altered in ASD.

Identifiants

DOI: 10.1016/j.tig.2022.06.001 PMID: 35750536
pubmed: 35750536
pii: S0168-9525(22)00143-3
doi: 10.1016/j.tig.2022.06.001
pii:
doi:

Substances chimiques

Chromatin 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

892-894

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Auteurs

Eden Engal (E)

Department of Biochemistry and Molecular Biology, Institute for Medical Research Israel-Canada, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel.

Mai Baker (M)

Department of Biochemistry and Molecular Biology, Institute for Medical Research Israel-Canada, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel.

Maayan Salton (M)

Department of Biochemistry and Molecular Biology, Institute for Medical Research Israel-Canada, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel. Electronic address: maayan.salton@mail.huji.ac.il.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles généralisés du développement de l'enfant › Trouble du spectre autistique › The chromatin roots of abnormal splicing in autism.
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles généralisés du développement de l'enfant › Trouble du spectre autistique › Trouble autistique › The chromatin roots of abnormal splicing in autism.
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › The chromatin roots of abnormal splicing in autism.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › The chromatin roots of abnormal splicing in autism.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The chromatin roots of abnormal splicing in autism.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Maturation post-transcriptionnelle des ARN › Épissage des ARN › The chromatin roots of abnormal splicing in autism.