Neutrophils in homeostasis and tissue repair.
granulocytes
immunity
inflammation
steady state
Journal
International immunology
ISSN: 1460-2377
Titre abrégé: Int Immunol
Pays: England
ID NLM: 8916182
Informations de publication
Date de publication:
26 07 2022
26 07 2022
Historique:
received:
07
04
2022
accepted:
25
06
2022
pubmed:
26
6
2022
medline:
29
7
2022
entrez:
25
6
2022
Statut:
ppublish
Résumé
Neutrophils are the most abundant innate immune cell and are equipped with highly destructive molecular cargo. As such, these cells were long thought to be short-lived killer cells that unleash their full cytotoxic programs on pathogens following infection and on host bystander cells after sterile injury. However, this view of neutrophils is overly simplistic and as a result is outdated. Numerous studies now collectively highlight neutrophils as far more complex and having a host of homeostatic and tissue-reparative functions. In this review, we summarize these underappreciated roles across organs and injury models.
Identifiants
pubmed: 35752158
pii: 6618055
doi: 10.1093/intimm/dxac029
pmc: PMC9317988
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
399-407Subventions
Organisme : CIHR
Pays : Canada
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of The Japanese Society for Immunology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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