The relationship between adverse childhood experiences and common mental disorders among pregnant women living with HIV in Malawi.
ACE-IQ
Adverse childhood experiences
Mental health
Pregnant women living with HIV
Prevalence
Resource-limited settings
Journal
Journal of affective disorders
ISSN: 1573-2517
Titre abrégé: J Affect Disord
Pays: Netherlands
ID NLM: 7906073
Informations de publication
Date de publication:
01 09 2022
01 09 2022
Historique:
received:
25
11
2021
revised:
28
05
2022
accepted:
16
06
2022
pubmed:
26
6
2022
medline:
12
7
2022
entrez:
25
6
2022
Statut:
ppublish
Résumé
Adverse childhood experiences (ACEs) have been linked to common mental disorders (CMDs) such as anxiety and depressive thoughts. We examined the prevalence of ACEs and their association with CMDs among pregnant women living with HIV (PWLHIV) in Malawi-an HIV endemic resource-limited setting. This is a cross-sectional study of 798 PWLHIV enrolled in the VITAL Start trial in Malawi (10/2018 to 06/2021) (NCT03654898). ACE histories were assessed using WHO's Adverse Childhood Experiences International Questionnaire (ACE-IQ) tool. Depressive symptoms (somatic complaints, reduced vital energy, anxiety, and depressive thoughts) were assessed using WHO's Self Reporting Questionnaire 20-Item (SRQ-20) tool. Log-binomial regressions were used to examine the association between cumulative ACEs and each depressive symptom, as well as identify ACEs driving this association. The mean age of our sample was 27.5 years. Over 95 % reported having experienced ≥1 ACE. On average, each participant reported four ACEs; 11 % reported sexual abuse. About 52 % and 44 % reported anxiety and depressive thoughts, respectively. In regressions, cumulative ACE scores were significantly associated with depressive symptoms-even after adjusting for multiple testing. This association was primarily driven by reports of sexual abuse. Data on maternal ACEs were self-reported and could suffer from measurement error because of recall bias. ACEs are widespread and have a graded relationship with depressive symptoms in motherhood. Sexual abuse was found to be a primary driver of this association. Earlier recognition of ACEs and provision of trauma-informed interventions to improve care in PWLHIV may reduce negative mental health sequelae.
Identifiants
pubmed: 35752220
pii: S0165-0327(22)00687-5
doi: 10.1016/j.jad.2022.06.028
pmc: PMC9892657
mid: NIHMS1865108
pii:
doi:
Types de publication
Clinical Trial
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
159-168Subventions
Organisme : NICHD NIH HHS
ID : K12 HD052023
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH115793
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier B.V. All rights reserved.
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