Physiologically relevant curcuminoids inhibit angiogenesis via VEGFR2 in human aortic endothelial cells.
Angiogenesis Inhibitors
/ pharmacology
Cell Movement
Cell Proliferation
Curcumin
/ therapeutic use
Diarylheptanoids
/ metabolism
Human Umbilical Vein Endothelial Cells
/ metabolism
Humans
Neovascularization, Pathologic
/ drug therapy
Vascular Endothelial Growth Factor A
/ drug effects
Vascular Endothelial Growth Factor Receptor-2
/ drug effects
Cell metabolism
Migration
Polyphenols
Tubulogenesis
VEGF
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
ISSN: 1873-6351
Titre abrégé: Food Chem Toxicol
Pays: England
ID NLM: 8207483
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
15
04
2022
revised:
02
06
2022
accepted:
20
06
2022
pubmed:
26
6
2022
medline:
20
7
2022
entrez:
25
6
2022
Statut:
ppublish
Résumé
Angiogenesis is a complex process encompassing endothelial cell proliferation, migration, and tube formation. While numerous studies describe that curcumin exerts antitumor properties (e.g., targeting angiogenesis), information regarding other dietary curcuminoids such as demethoxycurcumin (DMC) and bisdemethoxycurcumin (BisDMC) is scant. In this study, we evaluated the antiangiogenic activities of these three curcuminoids at physiological concentrations (0.1-5 μM) on endothelial cell migration and tubulogenesis and the underlying associated mechanisms on human aortic endothelial cells (HAECs). Results showed that the individual compounds and a representative mixture inhibited the tubulogenic and migration capacity of endothelial cells dose-dependently, while sparing cell viability. Notably, DMC and BisDMC at 0.1 and 1 μM showed higher capacity than curcumin inhibiting tubulogenesis. These compounds also reduced phosphorylation of the VEGFR2 and the downstream ERK and Akt pathways in VEGF
Identifiants
pubmed: 35752269
pii: S0278-6915(22)00452-5
doi: 10.1016/j.fct.2022.113254
pii:
doi:
Substances chimiques
Angiogenesis Inhibitors
0
Diarylheptanoids
0
Vascular Endothelial Growth Factor A
0
Vascular Endothelial Growth Factor Receptor-2
EC 2.7.10.1
Curcumin
IT942ZTH98
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113254Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.