Synthesis and anticancer evaluations of novel 1H-imidazole [4,5-f][1,10] phenanthroline derivative for the treatment of colorectal cancer.

Antineoplastic Agents / therapeutic use Apoptosis Cell Line, Tumor Cell Proliferation Colorectal Neoplasms / drug therapy HCT116 Cells Humans Imidazoles / pharmacology Molecular Docking Simulation Phenanthrolines / pharmacology Phosphatidylinositol 3-Kinases / metabolism
1H-imidazole [4,5-f][1,10] phenanthroline Apoptosis Cell cycle Colorectal cancer mTOR

Journal

European journal of pharmacology
ISSN: 1879-0712
Titre abrégé: Eur J Pharmacol
Pays: Netherlands
ID NLM: 1254354

Informations de publication

Date de publication:
05 Aug 2022
Historique:
received: 20 11 2021
revised: 17 06 2022
accepted: 21 06 2022
pubmed: 27 6 2022
medline: 14 7 2022
entrez: 26 6 2022
Statut: ppublish

Résumé

1H-imidazole [4,5-f][1,10] phenanthroline is a promising chemical structure for cancer treatment. Herein, we synthesized a novel 1H-imidazole [4,5-f][1,10] phenanthroline derivative named IPM714 and found it exhibited selectively colorectal cancer (CRC) cells inhibitory activities, with half maximal inhibitory concentration (IC

Identifiants

DOI: 10.1016/j.ejphar.2022.175120 PMID: 35753402
pubmed: 35753402
pii: S0014-2999(22)00381-8
doi: 10.1016/j.ejphar.2022.175120
pii:
doi:

Substances chimiques

Antineoplastic Agents 0
Imidazoles 0
Phenanthrolines 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

175120

Informations de copyright

Copyright © 2022 Elsevier B.V. All rights reserved.

Auteurs

Shujian Hu (S)

School of Pharmacy, Lanzhou University, 199 Donggang West Road, Lanzhou, 730000, PR China.

Wantong Ma (W)

School of Pharmacy, Lanzhou University, 199 Donggang West Road, Lanzhou, 730000, PR China.

Junyi Wang (J)

College of Science and Technology, Wenzhou-Kean University, 88 Daxue Road, Wenzhou, 325060, PR China.

Yunhao Ma (Y)

School of Pharmacy, Lanzhou University, 199 Donggang West Road, Lanzhou, 730000, PR China.

Zhongkun Zhou (Z)

School of Pharmacy, Lanzhou University, 199 Donggang West Road, Lanzhou, 730000, PR China.

Rentao Zhang (R)

School of Pharmacy, Lanzhou University, 199 Donggang West Road, Lanzhou, 730000, PR China.

Kangjia Du (K)

School of Pharmacy, Lanzhou University, 199 Donggang West Road, Lanzhou, 730000, PR China.

Hao Zhang (H)

School of Pharmacy, Lanzhou University, 199 Donggang West Road, Lanzhou, 730000, PR China.

Mengze Sun (M)

School of Pharmacy, Lanzhou University, 199 Donggang West Road, Lanzhou, 730000, PR China.

Xinrong Jiang (X)

School of Pharmacy, Lanzhou University, 199 Donggang West Road, Lanzhou, 730000, PR China.

Hongyuan Tu (H)

School of Pharmacy, Lanzhou University, 199 Donggang West Road, Lanzhou, 730000, PR China.

Xiaoliang Tang (X)

College of Chemistry and Chemical Engineering, Lanzhou University, 222 Tianshui South Road, Lanzhou, 730000, PR China.

Xiaojun Yao (X)

Macau Institute for Applied Research in Medicine and Health, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau.

Peng Chen (P)

School of Pharmacy, Lanzhou University, 199 Donggang West Road, Lanzhou, 730000, PR China. Electronic address: chenpeng@lzu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Synthesis and anticancer evaluations of novel...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Synthesis and anticancer evaluations of novel...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Synthesis and anticancer evaluations of novel...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Synthesis and anticancer evaluations of novel...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › Synthesis and anticancer evaluations of novel...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Cellules HCT116 › Synthesis and anticancer evaluations of novel...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Synthesis and anticancer evaluations of novel...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Synthesis and anticancer evaluations of novel...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Synthesis and anticancer evaluations of novel...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Phénanthrolines › Synthesis and anticancer evaluations of novel...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphatidylinositol 3-kinases › Synthesis and anticancer evaluations of novel...