Inhaled nitric oxide: role in the pathophysiology of cardio-cerebrovascular and respiratory diseases.
Blood transfusion
Brain disorder
Cardiac arrest
Cardiopulmonary bypass
Endothelial dysfunction
Hemolysis
Ischemia reperfusion
Nitric oxide
Pulmonary hypertension
Shunt
Toxicology
Journal
Intensive care medicine experimental
ISSN: 2197-425X
Titre abrégé: Intensive Care Med Exp
Pays: Germany
ID NLM: 101645149
Informations de publication
Date de publication:
27 Jun 2022
27 Jun 2022
Historique:
received:
27
12
2021
accepted:
08
06
2022
entrez:
26
6
2022
pubmed:
27
6
2022
medline:
27
6
2022
Statut:
epublish
Résumé
Nitric oxide (NO) is a key molecule in the biology of human life. NO is involved in the physiology of organ viability and in the pathophysiology of organ dysfunction, respectively. In this narrative review, we aimed at elucidating the mechanisms behind the role of NO in the respiratory and cardio-cerebrovascular systems, in the presence of a healthy or dysfunctional endothelium. NO is a key player in maintaining multiorgan viability with adequate organ blood perfusion. We report on its physiological endogenous production and effects in the circulation and within the lungs, as well as the pathophysiological implication of its disturbances related to NO depletion and excess. The review covers from preclinical information about endogenous NO produced by nitric oxide synthase (NOS) to the potential therapeutic role of exogenous NO (inhaled nitric oxide, iNO). Moreover, the importance of NO in several clinical conditions in critically ill patients such as hypoxemia, pulmonary hypertension, hemolysis, cerebrovascular events and ischemia-reperfusion syndrome is evaluated in preclinical and clinical settings. Accordingly, the mechanism behind the beneficial iNO treatment in hypoxemia and pulmonary hypertension is investigated. Furthermore, investigating the pathophysiology of brain injury, cardiopulmonary bypass, and red blood cell and artificial hemoglobin transfusion provides a focus on the potential role of NO as a protective molecule in multiorgan dysfunction. Finally, the preclinical toxicology of iNO and the antimicrobial role of NO-including its recent investigation on its role against the Sars-CoV2 infection during the COVID-19 pandemic-are described.
Identifiants
pubmed: 35754072
doi: 10.1186/s40635-022-00455-6
pii: 10.1186/s40635-022-00455-6
pmc: PMC9234017
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
28Subventions
Organisme : NHLBI NIH HHS
ID : R01HL142809
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL128882
Pays : United States
Informations de copyright
© 2022. The Author(s).
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