Unraveling docking and initiation of mRNA export through the nuclear pore complex.
Journal
BioEssays : news and reviews in molecular, cellular and developmental biology
ISSN: 1521-1878
Titre abrégé: Bioessays
Pays: United States
ID NLM: 8510851
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
revised:
18
05
2022
received:
01
02
2022
accepted:
03
06
2022
pubmed:
28
6
2022
medline:
26
7
2022
entrez:
27
6
2022
Statut:
ppublish
Résumé
The nuclear export of mRNA through the nuclear pore complex (NPC) is a process required for the healthy functioning of human cells, making it a critical area of research. However, the geometries of mRNA and the NPC are well below the diffraction limit of light microscopy, thereby presenting significant challenges in evaluating the discrete interactions and dynamics involved in mRNA nuclear export through the native NPC. Recent advances in biotechnology and single-molecule super-resolution light microscopy have enabled researchers to gain granular insight into the specific contributions made by discrete nucleoporins in the nuclear basket of the NPC to the export of mRNA. Specifically, by expanding upon the docking step facilitated by the protein TPR in the nuclear basket as well as identifying NUP153 as being the primary nuclear basket protein initiating export through the central channel of the NPC.
Identifiants
pubmed: 35754154
doi: 10.1002/bies.202200027
pmc: PMC9308666
mid: NIHMS1819988
doi:
Substances chimiques
NUP153 protein, human
0
Nuclear Pore Complex Proteins
0
Nuclear Proteins
0
RNA, Messenger
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2200027Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM116204
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM122552
Pays : United States
Informations de copyright
© 2022 Wiley Periodicals LLC.
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