Case Report: Arterial Wall Inflammation in Atherosclerotic Cardiovascular Disease is Reduced by Olamkicept (sgp130Fc).
atherosclerosis
case report
interleukin-6
olamkicept
sgp130Fc
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2022
2022
Historique:
received:
13
08
2021
accepted:
09
05
2022
entrez:
27
6
2022
pubmed:
28
6
2022
medline:
28
6
2022
Statut:
epublish
Résumé
Inflammation is a strong driver of atherosclerotic cardiovascular disease (ASCVD). There is a large unmet need for therapies that prevent or reduce excessive inflammation while avoiding systemic immunosuppression. We showed previously that selective inhibition of pro-inflammatory interleukin-6 (IL-6) trans-signalling by the fusion protein olamkicept (sgp130Fc) prevented and reduced experimental murine atherosclerosis in low-density lipoprotein receptor-deficient (
Identifiants
pubmed: 35754497
doi: 10.3389/fphar.2022.758233
pii: 758233
pmc: PMC9218605
doi:
Types de publication
Case Reports
Langues
eng
Pagination
758233Informations de copyright
Copyright © 2022 Schulte, Waetzig, Schuett, Marx, Schulte, Garbers, Lokau, Vlacil, Schulz, Seoudy, Schieffer, Rosenstiel, Seeger, Laudes, Rose-John, Lützen, Grote and Schreiber.
Déclaration de conflit d'intérêts
GHW is employed by CONARIS Research Institute AG, a company that owns the intellectual property (IP) rights to olamkicept, and is an inventor of such IP. SR-J and SS are consultants to CONARIS and members of CONARIS’ supervisory board. SR-J is a direct shareholder of CONARIS. CONARIS’ IP regarding olamkicept has been licensed to Ferring Pharmaceuticals (Saint-Prex, CH). None of the other authors have any conflicts of interest, financial or otherwise, to disclose in connection to this work. In particular, the clinicians who decided on the compassionate use of olamkicept and treated the patient, had no conflict of interest. The results of the present work have been protected by a European patent application of Kiel University with the inventors DMS, GHW, ML, and SS.
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