Pharmacogenetics of Praziquantel Metabolism: Evaluating the Cytochrome P450 Genes of Zimbabwean Patients During a Schistosomiasis Treatment.

PZQ SNP cytochrome P450 drug metabolism pharmacogenetics praziquantel schistosomiasis single nucleotide polymorphisms

Journal

Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621

Informations de publication

Date de publication:
2022
Historique:
received: 06 04 2022
accepted: 17 05 2022
entrez: 27 6 2022
pubmed: 28 6 2022
medline: 28 6 2022
Statut: epublish

Résumé

Schistosomiasis is a parasitic disease infecting over 236 million people annually, with the majority affected residing on the African continent. Control of this disease is reliant on the drug praziquantel (PZQ), with treatment success dependent on an individual reaching PZQ concentrations lethal to schistosomes. Despite the complete reliance on PZQ to treat schistosomiasis in Africa, the characterization of the pharmacogenetics associated with PZQ metabolism in African populations has been sparse. We aimed to characterize genetic variation in the drug-metabolising cytochrome P450 enzymes (CYPs) and determine the association between each variant and the efficacy of PZQ treatment in Zimbabwean patients exposed to

Identifiants

DOI: 10.3389/fgene.2022.914372 PMID: 35754834 PMC: PMC9213834
pubmed: 35754834
doi: 10.3389/fgene.2022.914372
pii: 914372
pmc: PMC9213834
doi:

Types de publication

Journal Article

Langues

eng

Pagination

914372

Informations de copyright

Copyright © 2022 Zdesenko, Mduluza and Mutapi.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Références

Science. 2009 May 22;324(5930):1035-44
pubmed: 19407144
PLoS Negl Trop Dis. 2020 Sep 25;14(9):e0008649
pubmed: 32976496
Br J Pharmacol. 2014 Feb;171(3):580-94
pubmed: 23981051
ChemMedChem. 2006 Jan;1(1):73-81
pubmed: 16892339
Clin Pharmacol Ther. 2017 Oct;102(4):688-700
pubmed: 28378927
Eur J Clin Pharmacol. 2001 Apr;57(1):11-7
pubmed: 11372584
Eur J Clin Pharmacol. 2019 Aug;75(8):1077-1087
pubmed: 31089768
Clin Pharmacol Ther. 2006 Jan;79(1):103-13
pubmed: 16413245
New Microbes New Infect. 2020 Nov;38:100821
pubmed: 33251016
Clin Pharmacol Ther. 1995 Jun;57(6):656-61
pubmed: 7781265
Hum Genomics. 2009 Jan;3(2):169-90
pubmed: 19164093
Pharmaceutics. 2020 Aug 26;12(9):
pubmed: 32858798
Front Immunol. 2021 Mar 12;12:635869
pubmed: 33790908
Nucleic Acids Res. 2003 Jul 1;31(13):3812-4
pubmed: 12824425
Drug Discov Today. 2007 Jan;12(1-2):34-42
pubmed: 17198971
N Engl J Med. 2005 May 26;352(21):2211-21
pubmed: 15917386
Clin Pharmacol Ther. 2018 Mar;103(3):399-401
pubmed: 29134625
J Biochem. 1999 Apr;125(4):803-8
pubmed: 10101295
N Engl J Med. 2002 Apr 18;346(16):1212-20
pubmed: 11961151
Bioinformatics. 2016 Nov 15;32(22):3513-3515
pubmed: 27412093
Nucleic Acids Res. 2001 Jan 1;29(1):308-11
pubmed: 11125122
Nucleic Acids Res. 2012 Jan;40(Database issue):D1308-12
pubmed: 22140107
Eur J Clin Pharmacol. 2010 Dec;66(12):1217-27
pubmed: 20842355
Nat Methods. 2014 Mar;11(3):294-6
pubmed: 24487584
PLoS Negl Trop Dis. 2014 Nov 20;8(11):e3286
pubmed: 25412105
Science. 2002 Jun 21;296(5576):2225-9
pubmed: 12029063
PLoS Negl Trop Dis. 2020 Jun 22;14(6):e0008388
pubmed: 32569278
Pharmacogenet Genomics. 2009 Oct;19(10):800-12
pubmed: 19752777
Brief Bioinform. 2012 May;13(3):292-304
pubmed: 21908865
Br J Clin Pharmacol. 2008 Apr;65(4):558-64
pubmed: 18070221
Int J Methods Psychiatr Res. 2018 Jun;27(2):e1608
pubmed: 29484742
Glob Health Epidemiol Genom. 2016 May 27;1:e9
pubmed: 29868201
PLoS One. 2017 Sep 21;12(9):e0183424
pubmed: 28934216
J Infect Dis. 2017 Dec 12;216(11):1425-1433
pubmed: 28968877
EBioMedicine. 2017 Mar;17:67-74
pubmed: 28237373
Front Pharmacol. 2021 Aug 31;12:712084
pubmed: 34531744
PLoS One. 2018 Aug 6;13(8):e0201904
pubmed: 30080866
Annu Rev Pharmacol Toxicol. 2001;41:101-21
pubmed: 11264452
Parasitology. 2009 Nov;136(13):1859-74
pubmed: 19906318
Infect Dis Poverty. 2017 Apr 7;6(1):85
pubmed: 28388940
Nat Genet. 2001 Apr;27(4):383-91
pubmed: 11279519
Trans R Soc Trop Med Hyg. 2008 Aug;102(8):759-66
pubmed: 18486169
Clin Chim Acta. 2008 Oct;396(1-2):76-9
pubmed: 18680736
PLoS Negl Trop Dis. 2020 Dec 14;14(12):e0008866
pubmed: 33315875
J Pharmacokinet Pharmacodyn. 2018 Oct;45(5):747-762
pubmed: 30218416
Drug Metab Dispos. 2005 Jul;33(7):884-7
pubmed: 15833928
Clin Chem Lab Med. 2004;42(8):939-41
pubmed: 15387446
Pharmacogenomics J. 2017 Jan;17(1):61-68
pubmed: 26667830
Brain Res Bull. 1997;44(5):561-71
pubmed: 9365799
Eur J Clin Pharmacol. 2012 Sep;68(9):1267-74
pubmed: 22418828
Eur J Hum Genet. 2008 Jul;16(7):780-3
pubmed: 18382479
Pharmacogenomics. 2021 Mar;22(4):213-223
pubmed: 33586456
J Hum Genet. 2007;52(11):871-880
pubmed: 17928948
Parasit Vectors. 2014 Mar 25;7:125
pubmed: 24667030
Per Med. 2020 Mar;17(2):155-170
pubmed: 32125935
Annu Rev Genomics Hum Genet. 2001;2:9-39
pubmed: 11701642
Bioinformatics. 2005 Jan 15;21(2):263-5
pubmed: 15297300
PLoS One. 2012;7(8):e42537
pubmed: 22916133
Nature. 2015 Oct 1;526(7571):68-74
pubmed: 26432245
Science. 1999 Oct 15;286(5439):487-91
pubmed: 10521338
Br J Clin Pharmacol. 1996 Dec;42(6):713-9
pubmed: 8971426
Pharmacogenomics J. 2001;1(3):157-8
pubmed: 11908747
PLoS One. 2014 Aug 15;9(8):e105250
pubmed: 25126975
Br J Clin Pharmacol. 2016 Jul;82(1):185-98
pubmed: 26991336
Am J Hum Genet. 2007 Sep;81(3):559-75
pubmed: 17701901
World J Gastroenterol. 2014 Aug 7;20(29):9775-827
pubmed: 25110414
Hum Mutat. 2008 Jan;29(1):6-13
pubmed: 18000842
Nucleic Acids Res. 2007 Jan;35(Database issue):D610-7
pubmed: 17148474
Curr Drug Metab. 2019;20(7):609-618
pubmed: 31244435
Am J Trop Med Hyg. 2019 Sep;101(3):617-627
pubmed: 31287046
PLoS One. 2014 Apr 02;9(4):e93379
pubmed: 24695491
Nat Protoc. 2011 Feb;6(2):121-33
pubmed: 21293453
Nature. 2016 Sep 07;537(7619):S60-2
pubmed: 27602742
Biochem Pharmacol. 2014 Jul 15;90(2):166-78
pubmed: 24821110
Ann Pharmacother. 1995 Jun;29(6):619-24
pubmed: 7663035
Lancet Glob Health. 2019 Aug;7(8):e1118-e1129
pubmed: 31255591
Front Genet. 2012 Oct 10;3:206
pubmed: 23087703
Acta Pharm Sin B. 2020 Jan;10(1):91-104
pubmed: 31998606
Pharmacol Res Perspect. 2020 Aug;8(4):e00618
pubmed: 32700798
Am J Trop Med Hyg. 2017 Dec;97(6):1810-1817
pubmed: 29016344
Hum Genomics. 2010 Aug;4(6):402-5
pubmed: 20846929
PLoS Negl Trop Dis. 2009;3(1):e357
pubmed: 19159015

Auteurs

Grace Zdesenko (G)

Ashworth Laboratories, Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom.
Ashworth Laboratories, NIHR Global Health Research Unit Tackling Infections to Benefit Africa (TIBA), University of Edinburgh, Edinburgh, United Kingdom.

Takafira Mduluza (T)

Ashworth Laboratories, NIHR Global Health Research Unit Tackling Infections to Benefit Africa (TIBA), University of Edinburgh, Edinburgh, United Kingdom.
Department of Biochemistry, University of Zimbabwe, Harare, Zimbabwe.

Francisca Mutapi (F)

Ashworth Laboratories, Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom.
Ashworth Laboratories, NIHR Global Health Research Unit Tackling Infections to Benefit Africa (TIBA), University of Edinburgh, Edinburgh, United Kingdom.

Classifications MeSH