NMR-Driven Identification of Cinnamon Bud and Bark Components With Anti-Aβ Activity.
Alzheimer’s disease
Aβ peptides
NMR metabolic profiling
UPLC-HR-MS
anti-amiloidogenic compounds
antioxidant
cinnamon
Journal
Frontiers in chemistry
ISSN: 2296-2646
Titre abrégé: Front Chem
Pays: Switzerland
ID NLM: 101627988
Informations de publication
Date de publication:
2022
2022
Historique:
received:
14
03
2022
accepted:
26
04
2022
entrez:
27
6
2022
pubmed:
28
6
2022
medline:
28
6
2022
Statut:
epublish
Résumé
The anti-Alzheimer disease (AD) activity reported for an aqueous cinnamon bark extract prompted us to investigate and compare the anti-amyloidogenic properties of cinnamon extracts obtained from both bark and bud, the latter being a very little explored matrix. We prepared the extracts with different procedures (alcoholic, hydroalcoholic, or aqueous extractions). An efficient protocol for the rapid analysis of NMR spectra of cinnamon bud and bark extracts was set up, enabling the automatic identification and quantification of metabolites. Moreover, we exploited preparative reverse-phase (RP) chromatography to prepare fractions enriched in polyphenols, further characterized by UPLC-HR-MS. Then, we combined NMR-based molecular recognition studies, atomic force microscopy, and
Identifiants
pubmed: 35755250
doi: 10.3389/fchem.2022.896253
pii: 896253
pmc: PMC9214034
doi:
Types de publication
Journal Article
Langues
eng
Pagination
896253Informations de copyright
Copyright © 2022 Ciaramelli, Palmioli, Angotti, Colombo, De Luigi, Sala, Salmona and Airoldi.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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