Synthesis of Melatonin Derivatives and the Neuroprotective Effects on Parkinson's Disease Models of
C. elegans
Parkinson’s disease
antioxidant activity
derivative of melatonin
synthesis
Journal
Frontiers in chemistry
ISSN: 2296-2646
Titre abrégé: Front Chem
Pays: Switzerland
ID NLM: 101627988
Informations de publication
Date de publication:
2022
2022
Historique:
received:
12
04
2022
accepted:
28
04
2022
entrez:
27
6
2022
pubmed:
28
6
2022
medline:
28
6
2022
Statut:
epublish
Résumé
Melatonin (MT) is a hormone with antioxidant activity secreted by the pineal gland in the human brain, which is highly efficient in scavenging free radicals and plays an important role in the neuro-immuno-endocrine system. Emerging evidence showed that MT supplementation was a potential therapeutic strategy for Parkinson's disease (PD), which inhibits pathways associated with oxidative stress in PD. In this study, we reported a C7-selective olefination of melatonin under rhodium catalysis with the aid of P
Identifiants
pubmed: 35755259
doi: 10.3389/fchem.2022.918116
pii: 918116
pmc: PMC9213837
doi:
Types de publication
Journal Article
Langues
eng
Pagination
918116Informations de copyright
Copyright © 2022 He, Du, Zhou, Chen, Luo, Li, Zhang, Ma, Ma and Feng.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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