Copper Modulates the Catalytic Activity of Protein Kinase CK2.
casein kinase 2 (CK2)
cell signaling
copper
kinase regulation
phosphorylation
protein kinase (CK2)
Journal
Frontiers in molecular biosciences
ISSN: 2296-889X
Titre abrégé: Front Mol Biosci
Pays: Switzerland
ID NLM: 101653173
Informations de publication
Date de publication:
2022
2022
Historique:
received:
18
02
2022
accepted:
12
05
2022
entrez:
27
6
2022
pubmed:
28
6
2022
medline:
28
6
2022
Statut:
epublish
Résumé
Casein kinase 2 (CK2) is an evolutionarily conserved serine/threonine kinase implicated in a wide range of cellular functions and known to be dysregulated in various diseases such as cancer. Compared to most other kinases, CK2 exhibits several unusual properties, including dual co-substrate specificity and a high degree of promiscuity with hundreds of substrates described to date. Most paradoxical, however, is its apparent constitutive activity: no definitive mode of catalytic regulation has thus far been identified. Here we demonstrate that copper enhances the enzymatic activity of CK2 both
Identifiants
pubmed: 35755824
doi: 10.3389/fmolb.2022.878652
pii: 878652
pmc: PMC9224766
doi:
Types de publication
Journal Article
Langues
eng
Pagination
878652Subventions
Organisme : NIEHS NIH HHS
ID : P30 ES013508
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM124749
Pays : United States
Informations de copyright
Copyright © 2022 Chojnowski, Li, Tsang, Alfaran, Dick, Cocklin, Brady and Strochlic.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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