Zika a Vector Borne Disease Detected in Newer States of India Amidst the COVID-19 Pandemic.
India
Zika virus
dengue serotype
microcephaly
next generation sequencing
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2022
2022
Historique:
received:
02
03
2022
accepted:
02
05
2022
entrez:
27
6
2022
pubmed:
28
6
2022
medline:
28
6
2022
Statut:
epublish
Résumé
During the second wave of the COVID-19 pandemic, outbreaks of Zika were reported from Kerala, Uttar Pradesh, and Maharashtra, India in 2021. The Dengue and Chikungunya negative samples were retrospectively screened to determine the presence of the Zika virus from different geographical regions of India. During May to October 2021, the clinical samples of 1475 patients, across 13 states and a union territory of India were screened and re-tested for Dengue, Chikungunya and Zika by CDC Trioplex Real time RT-PCR. The Zika rRTPCR positive samples were further screened with anti-Zika IgM and Plaque Reduction Neutralization Test. Next generation sequencing was used for further molecular characterization. The positivity was observed for Zika (67), Dengue (121), and Chikungunya (10) amongst screened cases. The co-infections of Dengue/Chikungunya, Dengue/Zika, and Dengue/Chikungunya/Zika were also observed. All Zika cases were symptomatic with fever (84%) and rash (78%) as major presenting symptoms. Of them, four patients had respiratory distress, one presented with seizures, and one with suspected microcephaly at birth. The Asian Lineage of Zika and all four serotypes of Dengue were found in circulation. Our study indicates the spread of the Zika virus to several states of India and an urgent need to strengthen its surveillance.
Sections du résumé
Background
UNASSIGNED
During the second wave of the COVID-19 pandemic, outbreaks of Zika were reported from Kerala, Uttar Pradesh, and Maharashtra, India in 2021. The Dengue and Chikungunya negative samples were retrospectively screened to determine the presence of the Zika virus from different geographical regions of India.
Methods
UNASSIGNED
During May to October 2021, the clinical samples of 1475 patients, across 13 states and a union territory of India were screened and re-tested for Dengue, Chikungunya and Zika by CDC Trioplex Real time RT-PCR. The Zika rRTPCR positive samples were further screened with anti-Zika IgM and Plaque Reduction Neutralization Test. Next generation sequencing was used for further molecular characterization.
Results
UNASSIGNED
The positivity was observed for Zika (67), Dengue (121), and Chikungunya (10) amongst screened cases. The co-infections of Dengue/Chikungunya, Dengue/Zika, and Dengue/Chikungunya/Zika were also observed. All Zika cases were symptomatic with fever (84%) and rash (78%) as major presenting symptoms. Of them, four patients had respiratory distress, one presented with seizures, and one with suspected microcephaly at birth. The Asian Lineage of Zika and all four serotypes of Dengue were found in circulation.
Conclusion
UNASSIGNED
Our study indicates the spread of the Zika virus to several states of India and an urgent need to strengthen its surveillance.
Identifiants
pubmed: 35756041
doi: 10.3389/fmicb.2022.888195
pmc: PMC9226610
doi:
Types de publication
Journal Article
Langues
eng
Pagination
888195Informations de copyright
Copyright © 2022 Yadav, Kaur, Gupta, Sahay, Sapkal, Shete, Deshpande, Mohandas, Majumdar, Patil, Pandit, Kumar, Nyayanit, Sreelatha, Manjusree, Sami, Khan, Malhotra, Dhingra, Gadepalli, Sudha Rani, Singh, Joshi, Dudhmal, Duggal, Chabbra, Dar, Gawande, Yemul, Kalele, Arjun, Nagamani, Borkakoty, Sahoo, Praharaj, Dutta, Barde, Jaryal and Rawat.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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