The impact of splenectomy on human lipid metabolism.
atherosclerosis
autotransplantation
coronary
homeostasis
hyperlipidemia
lipoprotein
Journal
Upsala journal of medical sciences
ISSN: 2000-1967
Titre abrégé: Ups J Med Sci
Pays: Sweden
ID NLM: 0332203
Informations de publication
Date de publication:
2022
2022
Historique:
received:
02
01
2022
revised:
27
04
2022
accepted:
27
04
2022
entrez:
27
6
2022
pubmed:
28
6
2022
medline:
29
6
2022
Statut:
epublish
Résumé
Splenectomy impacts hematological, immunological, and metabolic functions of the patient. Since our understanding of its metabolic effects, in particular effects on lipid metabolism, is limited, this study aims to investigate the effects of splenectomy on lipid metabolism. The data from 316 patients undergoing splenectomy between 2009 and 2019 were retrospectively analyzed. Thirty-eight patients whose serum lipid values were measured both preoperatively and 1 year after surgery were included in this study. Significantly higher levels of total cholesterol, low-density lipoprotein (LDL), and non-high-density lipoprotein (HDL) lipid profile were found in the postsplenectomy measurements. However, no significant differences were recorded in levels of triglyceride, HDL, or very-LDL. We determined that splenectomy does impact lipid metabolism, and that the metabolic effects of splenectomy should further be investigated.
Sections du résumé
Background
UNASSIGNED
Splenectomy impacts hematological, immunological, and metabolic functions of the patient. Since our understanding of its metabolic effects, in particular effects on lipid metabolism, is limited, this study aims to investigate the effects of splenectomy on lipid metabolism.
Methods
UNASSIGNED
The data from 316 patients undergoing splenectomy between 2009 and 2019 were retrospectively analyzed. Thirty-eight patients whose serum lipid values were measured both preoperatively and 1 year after surgery were included in this study.
Results
UNASSIGNED
Significantly higher levels of total cholesterol, low-density lipoprotein (LDL), and non-high-density lipoprotein (HDL) lipid profile were found in the postsplenectomy measurements. However, no significant differences were recorded in levels of triglyceride, HDL, or very-LDL.
Conclusion
UNASSIGNED
We determined that splenectomy does impact lipid metabolism, and that the metabolic effects of splenectomy should further be investigated.
Identifiants
pubmed: 35756571
doi: 10.48101/ujms.v127.8500
pii: 8500
pmc: PMC9199581
doi:
Substances chimiques
Cholesterol, HDL
0
Triglycerides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2022 The Author(s). Published by Upsala Medical Society.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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