Deciphering Metabolic Adaptability of Leukemic Stem Cells.

hematopoietic stem cells leukemia leukemic stem cells (LSCs) metabolic techniques metabolism

Journal

Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867

Informations de publication

Date de publication:
2022
Historique:
received: 30 12 2021
accepted: 16 05 2022
entrez: 27 6 2022
pubmed: 28 6 2022
medline: 28 6 2022
Statut: epublish

Résumé

Therapeutic targeting of leukemic stem cells is widely studied to control leukemia. An emerging approach gaining popularity is altering metabolism as a potential therapeutic opportunity. Studies have been carried out on hematopoietic and leukemic stem cells to identify vulnerable pathways without impacting the non-transformed, healthy counterparts. While many metabolic studies have been conducted using stem cells, most have been carried out

Identifiants

pubmed: 35756656
doi: 10.3389/fonc.2022.846149
pmc: PMC9213881
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

846149

Subventions

Organisme : NHLBI NIH HHS
ID : P01 HL131477
Pays : United States

Informations de copyright

Copyright © 2022 Patel, Nemkov, D’Alessandro and Welner.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Références

Cancer Discov. 2017 Jul;7(7):716-735
pubmed: 28416471
Leukemia. 2021 Dec;35(12):3371-3382
pubmed: 34120146
Oncotarget. 2016 Nov 29;7(48):79722-79735
pubmed: 27806325
J Biol Chem. 2001 Oct 12;276(41):37747-53
pubmed: 11489902
Cell Stem Cell. 2013 Mar 7;12(3):329-41
pubmed: 23333149
Mol Cancer Res. 2017 Dec;15(12):1692-1703
pubmed: 28835371
Cancer Cell. 2011 Nov 15;20(5):674-88
pubmed: 22094260
Cell Res. 2008 Aug;18(8):879-88
pubmed: 18663379
Nat Commun. 2015 Jul 29;6:7901
pubmed: 26219591
Nature. 2017 Mar 9;543(7644):205-210
pubmed: 28241143
Clin Cancer Res. 2015 Mar 15;21(6):1360-72
pubmed: 25547679
Haematologica. 2017 Dec;102(12):1985-1994
pubmed: 28883079
Sci Signal. 2018 Jul 10;11(538):
pubmed: 29991649
Sci Transl Med. 2019 Oct 30;11(516):
pubmed: 31666400
Sci Rep. 2018 Sep 28;8(1):14517
pubmed: 30266938
J Exp Med. 2017 Mar 6;214(3):719-735
pubmed: 28202494
Drug Des Devel Ther. 2020 May 27;14:2091-2100
pubmed: 32546972
Cell. 2014 Sep 11;158(6):1309-1323
pubmed: 25215489
Nature. 2021 Mar;591(7848):117-123
pubmed: 33442062
Cell Stem Cell. 2015 Nov 5;17(5):585-96
pubmed: 26440282
Blood Cancer J. 2018 Jan 24;8(1):13
pubmed: 29367649
Nat Methods. 2019 Nov;16(11):1123-1130
pubmed: 31611692
Cancer Discov. 2020 Dec;10(12):1797-1807
pubmed: 33139243
Cancer Discov. 2019 Jul;9(7):890-909
pubmed: 31048321
Nature. 2017 Sep 28;549(7673):476-481
pubmed: 28825709
Leukemia. 2021 Feb;35(2):377-388
pubmed: 32382081
Cell Stem Cell. 2016 Jul 7;19(1):23-37
pubmed: 27374788
Nature. 2017 May 25;545(7655):500-504
pubmed: 28514443
Sci Rep. 2018 Feb 20;8(1):3317
pubmed: 29463831
Blood Rev. 2019 Jul;36:70-87
pubmed: 31101526
Exp Hematol. 2018 Feb;58:52-58
pubmed: 28947392
Sci Rep. 2015 May 14;5:10194
pubmed: 25973915
J Exp Med. 2012 Nov 19;209(12):2183-98
pubmed: 23091163
Blood. 2009 Feb 26;113(9):2014-21
pubmed: 18978206
Cell Stem Cell. 2010 Sep 3;7(3):391-402
pubmed: 20804974
Cell Rep. 2019 Apr 2;27(1):238-254.e6
pubmed: 30943405
Oncotarget. 2015 Sep 8;6(26):22624-40
pubmed: 26265439
Blood. 2006 Jul 1;108(1):319-27
pubmed: 16527898
Cell. 2018 Apr 5;173(2):470-484.e18
pubmed: 29551267
Cancer Cell. 2019 Jul 8;36(1):84-99.e8
pubmed: 31287994
Cell Metab. 2016 Apr 12;23(4):649-62
pubmed: 27076078
Clin Cancer Res. 2009 May 15;15(10):3442-50
pubmed: 19401345
Blood. 2011 Dec 8;118(24):6399-402
pubmed: 22021366
Cell Metab. 2021 Sep 7;33(9):1777-1792.e8
pubmed: 34375613
Blood. 2018 Apr 12;131(15):1639-1653
pubmed: 29463564
Blood. 2015 Sep 10;126(11):1346-56
pubmed: 26186940
Leuk Lymphoma. 2012 Dec;53(12):2474-8
pubmed: 22616753
Cell Stem Cell. 2020 Nov 5;27(5):748-764.e4
pubmed: 32822582
Nat Commun. 2017 Nov 21;8(1):1646
pubmed: 29158483
Blood. 1993 Oct 1;82(7):2031-7
pubmed: 8104535
Rapid Commun Mass Spectrom. 2017 Apr 30;31(8):663-673
pubmed: 28195377
Analyst. 2019 Jan 28;144(3):782-793
pubmed: 30426983
Cell Metab. 2019 Feb 5;29(2):417-429.e4
pubmed: 30449684
Oncogene. 2016 Oct 27;35(43):5663-5673
pubmed: 27065330
Blood. 2015 Mar 5;125(10):1562-5
pubmed: 25593337
J Clin Invest. 2019 Jun 10;129(7):2685-2701
pubmed: 31180336
N Engl J Med. 2004 Aug 5;351(6):533-42
pubmed: 15295046
Cell Stem Cell. 2018 Jul 05;23(1):86-100.e6
pubmed: 29910151
Nat Med. 2017 Oct;23(10):1234-1240
pubmed: 28920959
Leukemia. 2018 Dec;32(12):2546-2557
pubmed: 30275526
Methods Mol Biol. 2018;1732:195-202
pubmed: 29480476
J Clin Med. 2016 Mar 05;5(3):
pubmed: 26959069
Cancer Cell. 2018 Nov 12;34(5):724-740.e4
pubmed: 30423294
Cell Stem Cell. 2010 Sep 3;7(3):380-90
pubmed: 20804973
Cell Rep. 2019 Jul 2;28(1):145-158.e9
pubmed: 31269436
N Engl J Med. 2016 Jun 9;374(23):2209-2221
pubmed: 27276561
Nat Med. 2012 Sep;18(9):1350-8
pubmed: 22902876
Blood. 2014 Apr 24;123(17):2663-72
pubmed: 24553174
Blood. 2021 Jun 24;137(25):3518-3532
pubmed: 33720355
Cell Metab. 2020 Sep 1;32(3):391-403.e6
pubmed: 32763164
Cell Stem Cell. 2020 Mar 5;26(3):420-430.e6
pubmed: 32059807
Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6669-E6678
pubmed: 27791036
Oncotarget. 2018 Sep 4;9(69):33124-33137
pubmed: 30237856
Leukemia. 2013 Apr;27(5):1090-9
pubmed: 23160450
Nat Commun. 2016 Oct 12;7:13125
pubmed: 27731316
Haematologica. 2014 May;99(5):858-64
pubmed: 24334295
Nat Cell Biol. 2019 Feb;21(2):238-250
pubmed: 30664790
Anal Chem. 2017 Nov 7;89(21):11664-11671
pubmed: 29028307
Cancer Gene Ther. 2020 Feb;27(1-2):15-21
pubmed: 30578412
Nat Cancer. 2020 Dec;1(12):1176-1187
pubmed: 33884374
Mol Cell Proteomics. 2018 Feb;17(2):290-303
pubmed: 29196338
Leukemia. 2006 Oct;20(10):1731-7
pubmed: 17041637
Cell Stem Cell. 2013 Jan 3;12(1):49-61
pubmed: 23290136
Leukemia. 2018 Aug;32(8):1860-1865
pubmed: 29749398
J Proteome Res. 2011 Sep 2;10(9):4165-76
pubmed: 21744784
Cell Stem Cell. 2013 Jan 3;12(1):62-74
pubmed: 23290137
Nature. 2017 Nov 2;551(7678):115-118
pubmed: 29045397
Elife. 2021 Jan 20;10:
pubmed: 33470192
Nat Commun. 2019 Aug 21;10(1):3763
pubmed: 31434891
Nat Cell Biol. 2012 Feb 19;14(3):276-86
pubmed: 22344033
Nat Protoc. 2017 Aug;12(8):1576-1587
pubmed: 28703790
Cell Stem Cell. 2021 Oct 7;28(10):1851-1867.e8
pubmed: 34293334
Leuk Lymphoma. 2007 May;48(5):912-22
pubmed: 17487735
J Biol Chem. 2000 Aug 11;275(32):24273-8
pubmed: 10833515
PLoS One. 2011;6(7):e21924
pubmed: 21789194
J Biol Chem. 2013 Nov 22;288(47):33542-33558
pubmed: 24089526
Nature. 2016 Jan 28;529(7587):528-31
pubmed: 26789249
Methods Mol Biol. 2019;1978:13-26
pubmed: 31119654
Cell Stem Cell. 2021 Feb 4;28(2):241-256.e6
pubmed: 33086034
Cell Death Dis. 2014 Oct 16;5:e1470
pubmed: 25321477
Curr Opin Clin Nutr Metab Care. 2017 Sep;20(5):366-374
pubmed: 28768294
Cell Death Dis. 2018 Aug 28;9(9):846
pubmed: 30154400
Br J Haematol. 2019 Apr;185(1):65-78
pubmed: 30656643
Mol Cancer Ther. 2018 Oct;17(10):2226-2237
pubmed: 30082471
Blood. 2019 Jul 25;134(4):389-394
pubmed: 31101624
J Clin Invest. 2010 Jan;120(1):142-56
pubmed: 20038799
Nat Med. 2018 Jul;24(7):1036-1046
pubmed: 29892070
Blood Cancer Discov. 2021 May;2(3):266-287
pubmed: 34027418
Cell Stem Cell. 2017 Dec 7;21(6):725-729.e4
pubmed: 29198942
Blood. 2012 May 3;119(18):4253-63
pubmed: 22411871
Nat Med. 2015 Oct;21(10):1182-9
pubmed: 26390244
Commun Biol. 2019 Jul 11;2:258
pubmed: 31312727
Mol Oncol. 2021 May;15(5):1412-1431
pubmed: 33314742

Auteurs

Sweta B Patel (SB)

Department of Medicine, Division of Hematology/Oncology, O'Neal Comprehensive Cancer Center, University of Alabama at, Birmingham, AL, United States.
Divison of Hematology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.

Travis Nemkov (T)

Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.

Angelo D'Alessandro (A)

Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.

Robert S Welner (RS)

Department of Medicine, Division of Hematology/Oncology, O'Neal Comprehensive Cancer Center, University of Alabama at, Birmingham, AL, United States.

Classifications MeSH