Murine Models of Acute Myeloid Leukemia.
acute myeliod leukemia
AML
KMT2a (MLL) rearrangements
NUP98 fusion
core binding factor acute myeliod leukemia
genetically engineered mice (GEM)
patient-derived xenograft (PDX)
transgenic mouse
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2022
2022
Historique:
received:
14
01
2022
accepted:
16
05
2022
entrez:
27
6
2022
pubmed:
28
6
2022
medline:
28
6
2022
Statut:
epublish
Résumé
Acute myeloid leukemia (AML) is a phenotypically and genetically heterogeneous hematologic malignancy. Extensive sequencing efforts have mapped the genomic landscape of adult and pediatric AML revealing a number of biologically and prognostically relevant driver lesions. Beyond identifying recurrent genetic aberrations, it is of critical importance to fully delineate the complex mechanisms by which they contribute to the initiation and evolution of disease to ultimately facilitate the development of targeted therapies. Towards these aims, murine models of AML are indispensable research tools. The rapid evolution of genetic engineering techniques over the past 20 years has greatly advanced the use of murine models to mirror specific genetic subtypes of human AML, define cell-intrinsic and extrinsic disease mechanisms, study the interaction between co-occurring genetic lesions, and test novel therapeutic approaches. This review summarizes the mouse model systems that have been developed to recapitulate the most common genomic subtypes of AML. We will discuss the strengths and weaknesses of varying modeling strategies, highlight major discoveries emanating from these model systems, and outline future opportunities to leverage emerging technologies for mechanistic and preclinical investigations.
Identifiants
pubmed: 35756660
doi: 10.3389/fonc.2022.854973
pmc: PMC9214208
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
854973Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2022 Kurtz, Conneely, O’Keefe, Wohlan and Rau.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Blood. 2010 Apr 22;115(16):3341-5
pubmed: 19666870
Oncogene. 1992 May;7(5):827-36
pubmed: 1570153
Cancer Cell. 2014 Apr 14;25(4):442-54
pubmed: 24656771
Blood. 2005 Jun 15;105(12):4792-9
pubmed: 15718420
Blood. 2015 Jan 22;125(4):629-38
pubmed: 25416277
Blood. 2013 Mar 28;121(13):2533-41
pubmed: 23361907
Blood. 2008 Aug 1;112(3):568-75
pubmed: 18523148
Blood. 2010 Nov 18;116(20):4086-94
pubmed: 20693432
Proc Soc Exp Biol Med. 1951 Jan;76(1):27-32
pubmed: 14816382
Br J Cancer. 1982 May;45(5):778-82
pubmed: 7044403
Int J Mol Sci. 2020 Jun 15;21(12):
pubmed: 32549410
PLoS One. 2012;7(11):e49769
pubmed: 23226219
J Exp Med. 1991 Jan 1;173(1):265-8
pubmed: 1985122
Toxicol Sci. 2009 Aug;110(2):293-306
pubmed: 19478238
Leukemia. 2010 Oct;24(10):1785-8
pubmed: 20686503
Genome Biol. 2010;11(12):R124
pubmed: 21182765
Blood. 2003 Sep 1;102(5):1857-65
pubmed: 12750176
Genes Dev. 2010 Jul 1;24(13):1389-402
pubmed: 20595231
Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13218-23
pubmed: 21788509
Nat Biotechnol. 2014 Apr;32(4):364-72
pubmed: 24633240
Blood. 1973 Jan;41(1):93-104
pubmed: 4508790
Haematologica. 2018 Jun;103(6):959-971
pubmed: 29545344
Exp Hematol. 2014 Feb;42(2):101-13.e5
pubmed: 24184354
Cancer Cell. 2011 Jul 12;20(1):66-78
pubmed: 21741597
PLoS One. 2012;7(6):e37892
pubmed: 22745659
Blood. 2011 Dec 1;118(23):6153-63
pubmed: 22012066
J Virol. 1984 Sep;51(3):586-94
pubmed: 6088784
Blood. 2013 Dec 12;122(25):4086-9
pubmed: 24167195
Nat Genet. 2011 Dec 04;44(1):23-31
pubmed: 22138693
Cancer Cell. 2006 Jan;9(1):57-68
pubmed: 16413472
Blood. 2010 Mar 11;115(10):1976-84
pubmed: 20053758
Cancer Cell. 2012 Nov 13;22(5):683-97
pubmed: 23153540
Cancer Cell. 2016 Jul 11;30(1):43-58
pubmed: 27344946
Genes (Basel). 2021 Jun 17;12(6):
pubmed: 34204358
Cancer Discov. 2019 Dec;9(12):1736-1753
pubmed: 31662298
Cancer. 2016 Dec 15;122(24):3821-3830
pubmed: 27529519
N Engl J Med. 2010 Dec 16;363(25):2424-33
pubmed: 21067377
Blood. 2006 Sep 1;108(5):1708-15
pubmed: 16675706
Br J Haematol. 2016 Nov;175(3):476-489
pubmed: 27470916
J Exp Med. 2015 Oct 19;212(11):1819-32
pubmed: 26438361
Nature. 2011 Oct 02;478(7370):529-33
pubmed: 21964340
J Immunol. 1989 Aug 15;143(4):1087-93
pubmed: 2473116
Cancer Chemother Rep. 1967 Jun;51(3):125-65
pubmed: 6043735
Nature. 1985 Dec 12-18;318(6046):533-8
pubmed: 3906410
Blood. 2012 Feb 9;119(6):1511-21
pubmed: 22160378
Haematologica. 2022 Apr 01;107(4):887-898
pubmed: 34092059
Blood. 2014 Jan 23;123(4):541-53
pubmed: 24255920
Hematology. 2021 Dec;26(1):111-122
pubmed: 33491606
Leukemia. 2022 Mar;36(3):675-686
pubmed: 34732858
J Clin Invest. 2005 Aug;115(8):2159-68
pubmed: 16025155
Leuk Res. 1987;11(2):119-33
pubmed: 3469482
Oncogene. 2016 Oct 27;35(43):5686-5691
pubmed: 27065320
Genes Chromosomes Cancer. 2019 Dec;58(12):875-888
pubmed: 31393631
Haematologica. 2009 Dec;94(12):1676-81
pubmed: 19797729
Blood. 1999 Jul 15;94(2):793-802
pubmed: 10397747
Nat Med. 2019 Mar;25(3):530
pubmed: 30705421
J Natl Cancer Inst. 1967 Jan;38(1):31-50
pubmed: 4289249
Oncotarget. 2018 Oct 19;9(82):35313-35326
pubmed: 30450160
Nat Med. 1997 Jul;3(7):730-7
pubmed: 9212098
Leukemia. 2013 Sep;27(9):1917-20
pubmed: 23478666
Blood. 2006 Feb 1;107(3):1166-73
pubmed: 16234360
Sci Rep. 2017 Feb 21;7:43113
pubmed: 28220884
J Exp Med. 2015 Oct 19;212(11):1833-50
pubmed: 26438359
Blood. 2013 Aug 15;122(7):1271-83
pubmed: 23838347
Comp Med. 2015 Apr;65(2):96-113
pubmed: 25926395
Blood. 2011 Oct 27;118(17):4509-18
pubmed: 21803851
Blood. 2016 May 19;127(20):2451-9
pubmed: 26980726
Blood. 2013 Jun 27;121(26):5203-7
pubmed: 23687087
Blood. 2015 Oct 1;126(14):1683-94
pubmed: 26311362
EMBO Mol Med. 2013 Dec;5(12):1804-20
pubmed: 24124051
J Exp Clin Cancer Res. 2022 Jan 24;41(1):34
pubmed: 35073946
Haematologica. 2021 Apr 01;106(4):1000-1007
pubmed: 32381577
Proc Natl Acad Sci U S A. 1988 Aug;85(16):6047-51
pubmed: 3261863
Blood. 2007 Aug 1;110(3):979-85
pubmed: 17440048
J Clin Invest. 2017 Feb 1;127(2):543-548
pubmed: 28067666
Sci Rep. 2012;2:273
pubmed: 22355785
J Exp Med. 2018 Jun 4;215(6):1729-1747
pubmed: 29643185
N Engl J Med. 2013 May 30;368(22):2059-74
pubmed: 23634996
Haematologica. 2015 Mar;100(3):324-30
pubmed: 25596267
Cancer Cell. 2008 Jun;13(6):483-95
pubmed: 18538732
Hematol Oncol. 2009 Dec;27(4):171-81
pubmed: 19569254
Leukemia. 2021 Oct;35(10):2983-2988
pubmed: 34148054
Cell. 2017 Sep 7;170(6):1062-1078
pubmed: 28886379
Nat Med. 2016 Dec;22(12):1488-1495
pubmed: 27841873
Blood. 2016 Oct 27;128(17):2130-2134
pubmed: 27581357
Blood. 2017 Jan 19;129(3):358-370
pubmed: 27815262
N Engl J Med. 2016 Jun 9;374(23):2209-2221
pubmed: 27276561
Haematologica. 2014 Sep;99(9):1465-71
pubmed: 24951466
Leukemia. 2013 Apr;27(4):852-60
pubmed: 23235717
Blood. 1997 Sep 1;90(5):1799-806
pubmed: 9292512
Cancer Discov. 2016 Oct;6(10):1166-1181
pubmed: 27535106
Nat Genet. 2011 Mar 13;43(4):309-15
pubmed: 21399634
Blood. 2014 Sep 11;124(11):1790-8
pubmed: 25006131
Cancer Cell. 2016 Jun 13;29(6):922-934
pubmed: 27300438
Cancer Cell. 2011 Jul 12;20(1):11-24
pubmed: 21723200
Nature. 2018 Oct;562(7728):526-531
pubmed: 30333627
Cell. 1996 Jun 14;85(6):853-61
pubmed: 8681380
Pediatr Blood Cancer. 2012 Apr;58(4):525-31
pubmed: 22331798
Nat Cell Biol. 2007 Jul;9(7):804-12
pubmed: 17589499
Blood. 2009 Feb 5;113(6):1304-14
pubmed: 19066392
Cancer Cell. 2012 Aug 14;22(2):180-93
pubmed: 22897849
Blood. 2022 Feb 10;139(6):894-906
pubmed: 34582559
Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10398-403
pubmed: 11526243
Blood. 2016 Aug 4;128(5):686-98
pubmed: 27288520
Int J Cancer. 2010 Apr 1;126(7):1621-9
pubmed: 19711340
Cancer Res. 2009 Feb 1;69(3):1109-16
pubmed: 19155294
Nat Commun. 2021 Jul 27;12(1):4549
pubmed: 34315901
Haematologica. 2012 Mar;97(3):388-92
pubmed: 22058207
Blood. 2016 May 19;127(20):2391-405
pubmed: 27069254
JCI Insight. 2018 Feb 22;3(4):
pubmed: 29467326
Blood. 2014 Apr 3;123(14):2209-19
pubmed: 24532805
Cell Physiol Biochem. 2014;33(1):78-87
pubmed: 24480914
J Exp Med. 2017 Oct 2;214(10):2901-2913
pubmed: 28827447
Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21113-8
pubmed: 24255108
Leukemia. 2018 Feb;32(2):273-284
pubmed: 28701730
Cancer Cell. 2011 Jul 12;20(1):25-38
pubmed: 21723201
Nat Med. 2016 Jul;22(7):812-21
pubmed: 27213817
Oncogene. 2005 Nov 24;24(53):7882-92
pubmed: 16116483
Nature. 1994 Feb 17;367(6464):645-8
pubmed: 7509044
Leukemia. 2009 Nov;23(11):2109-17
pubmed: 19626050
Pediatr Blood Cancer. 2011 Aug;57(2):204-9
pubmed: 21504050
Nat Commun. 2019 Mar 22;10(1):1347
pubmed: 30902969
Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2450-5
pubmed: 21262832
Leukemia. 2021 Jul;35(7):1949-1963
pubmed: 33159179
PLoS One. 2010 Aug 12;5(8):e12112
pubmed: 20711430
Blood. 2014 Feb 6;123(6):914-20
pubmed: 24335498
Cell. 1996 Nov 15;87(4):687-96
pubmed: 8929537
J Immunol. 1995 Jan 1;154(1):180-91
pubmed: 7995938
Blood. 2009 Sep 17;114(12):2489-96
pubmed: 19528532
Nat Med. 2006 Aug;12(8):945-9
pubmed: 16892037
Leukemia. 2015 Sep;29(9):1847-56
pubmed: 25801914
Blood. 2014 Feb 13;123(7):1069-78
pubmed: 24381225
Cancer Res. 1970 Jun;30(6):1883-97
pubmed: 4917694
Haematologica. 2015 May;100(5):e194-5
pubmed: 25596268
Nat Biotechnol. 2007 Nov;25(11):1315-21
pubmed: 17952057
Cancer Cell. 2007 Oct;12(4):367-80
pubmed: 17936561
Leukemia. 2017 Oct;31(10):2228-2234
pubmed: 28174417
Nat Genet. 2016 Sep;48(9):1014-23
pubmed: 27428748
J Exp Med. 2013 Nov 18;210(12):2641-59
pubmed: 24218140
Leukemia. 2011 Jul;25(7):1153-8
pubmed: 21415852
Ann N Y Acad Sci. 1954 Dec 6;60(2):244-50
pubmed: 14350530
J Clin Invest. 2004 Feb;113(4):528-38
pubmed: 14966562
Leukemia. 2019 Jul;33(7):1635-1649
pubmed: 30692594
Blood. 1996 Nov 15;88(10):3731-40
pubmed: 8916937
Nat Genet. 2011 May;43(5):470-5
pubmed: 21441929
Int J Cancer. 1974 Jun 15;13(6):867-78
pubmed: 4368851
Blood. 1997 Jan 15;89(2):376-87
pubmed: 9002938
N Engl J Med. 2005 Jan 20;352(3):254-66
pubmed: 15659725
Nat Genet. 2019 Apr;51(4):694-704
pubmed: 30926971
Cancer Metastasis Rev. 2020 Mar;39(1):189-209
pubmed: 31925603
Blood. 2008 Apr 1;111(7):3849-58
pubmed: 18245664
Cell Rep. 2014 Nov 20;9(4):1246-55
pubmed: 25456127
Theranostics. 2021 Jan 1;11(1):93-106
pubmed: 33391463
PLoS One. 2012;7(10):e46529
pubmed: 23056333
Blood. 2013 Apr 18;121(16):3076-84
pubmed: 23287864
Nat Chem Biol. 2012 Jan 29;8(3):277-84
pubmed: 22286128
Cancer Cell. 2016 Dec 12;30(6):863-878
pubmed: 27889185
PLoS One. 2014 Mar 07;9(3):e89560
pubmed: 24608088
Blood. 2020 Jul 23;136(4):387-400
pubmed: 32344427
Genes Dev. 2001 Dec 15;15(24):3243-8
pubmed: 11751630
Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):14566-71
pubmed: 21873190
Blood. 2014 Jul 3;124(1):13-23
pubmed: 24764564
EMBO J. 2005 Sep 7;24(17):3136-46
pubmed: 16096649
Blood. 2012 Aug 2;120(5):1130-6
pubmed: 22674806
Nature. 1968 Jan 27;217(5126):370-1
pubmed: 5639157
Blood. 1992 Apr 15;79(8):2089-98
pubmed: 1562735
Nature. 1983 Feb 10;301(5900):527-30
pubmed: 6823332
Hematology Am Soc Hematol Educ Program. 2017 Dec 8;2017(1):37-44
pubmed: 29222235
Cell Stem Cell. 2014 Sep 4;15(3):350-364
pubmed: 25130491
Blood. 2015 Jan 22;125(4):619-28
pubmed: 25416276
Nat Genet. 1999 Nov;23(3):348-53
pubmed: 10610183
Nat Rev Cancer. 2002 Jul;2(7):502-13
pubmed: 12094236
N Engl J Med. 2009 May 28;360(22):2289-301
pubmed: 19474426
Nat Genet. 1997 Mar;15(3):303-6
pubmed: 9054947
Curr Top Microbiol Immunol. 1989;149:45-57
pubmed: 2543543
EMBO Rep. 2000 Aug;1(2):127-32
pubmed: 11265751
Blood. 2020 Mar 12;135(11):845-856
pubmed: 31932841
Genet Res. 1966 Dec;8(3):295-309
pubmed: 5980117
Blood. 1999 Sep 1;94(5):1761-72
pubmed: 10477702
Cancer Cell. 2018 Jan 8;33(1):44-59.e8
pubmed: 29275866
Tumori. 1980 Oct 31;66(5):549-64
pubmed: 6936969
Blood. 2021 Mar 25;137(12):1628-1640
pubmed: 33512458
Blood. 2004 May 1;103(9):3544-6
pubmed: 14670924
Blood. 1997 Jun 1;89(11):3919-24
pubmed: 9166828
Genes Chromosomes Cancer. 2018 Aug;57(8):401-408
pubmed: 29663558
Nature. 2002 Dec 5;420(6915):520-62
pubmed: 12466850
Curr Opin Genet Dev. 2003 Feb;13(1):48-54
pubmed: 12573435
Cancers (Basel). 2020 Sep 26;12(10):
pubmed: 32993115
J Natl Cancer Inst. 1949 Aug;10(1):179-92
pubmed: 18143260
Nat Genet. 2021 Oct;53(10):1443-1455
pubmed: 34556857
Leukemia. 2013 Apr;27(4):813-22
pubmed: 23138183