The SARS-CoV-2 protein NSP2 impairs the silencing capacity of the human 4EHP-GIGYF2 complex.
Molecular biology
Virology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
15 Jul 2022
15 Jul 2022
Historique:
received:
04
02
2022
revised:
12
05
2022
accepted:
15
06
2022
pubmed:
28
6
2022
medline:
28
6
2022
entrez:
27
6
2022
Statut:
ppublish
Résumé
There is an urgent need for a molecular understanding of how SARS-CoV-2 influences the machineries of the host cell. Herein, we focused our attention on the capacity of the SARS-CoV-2 protein NSP2 to bind the human 4EHP-GIGYF2 complex, a key factor involved in microRNA-mediated silencing of gene expression. Using
Identifiants
pubmed: 35756894
doi: 10.1016/j.isci.2022.104646
pii: S2589-0042(22)00918-X
pmc: PMC9213009
doi:
Types de publication
Journal Article
Langues
eng
Pagination
104646Informations de copyright
© 2022 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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