Exercise and Rehabilitation in People With Ehlers-Danlos Syndrome: A Systematic Review.
6MWT, 6-minute walk test
AIMS-2, Arthritis Impact Measurement Scales-2
CONSORT, Consolidated Standards for Reporting of Trials
EDS, Ehlers-Danlos syndrome
Ehlers-Danlos Syndrome
Exercise
HADS, Hospital and Anxiety Depression Scale
HSD, hypermobility spectrum disorders
Joint instability
PEDro, Physiotherapy Evidence Database
PRISMA, Preferred Reporting Items for Systematic Reviews and Meta-Analyses
QOL, quality of life
RCT, randomized control trial
ROBINS-I, Risk Of Bias In Nonrandomized Studies of Interventions
Rehabilitation
SF-36, Short Form-36
VAS, visual analog scale
hEDS, hypermobile EDS
Journal
Archives of rehabilitation research and clinical translation
ISSN: 2590-1095
Titre abrégé: Arch Rehabil Res Clin Transl
Pays: United States
ID NLM: 101763542
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
entrez:
27
6
2022
pubmed:
28
6
2022
medline:
28
6
2022
Statut:
epublish
Résumé
To conduct a systematic review examining the effect of exercise and rehabilitation in people with Ehlers-Danlos syndrome (EDS). The following databases were systematically searched: MEDLINE, MEDLINE In-Process/ePubs, Embase, Cochrane Central Register of Controlled Trials, PsycINFO, and Cumulative Index to Nursing and Allied Health. The final time point captured by the search is November 27, 2020. Eligible study designs included case-control, case-series, prospective cohort, retrospective cohort, and intervention studies of structured exercise or rehabilitation interventions. Eligible populations included adults (18 years or older) with EDS (all subtypes) and hypermobility spectrum disorders. The search was restricted to articles published in English. Data were extracted by 2 independent reviewers. Risk of bias was assessed using the Physiotherapy Evidence Database (PEDro) scale for randomized controlled trials (RCTs) and Risk Of Bias In Nonrandomized Studies of Interventions (ROBINS-I) for non-RCTs. Reporting quality of RCTs was assessed using the Consolidated Standards for Reporting of Trials statement with the harms extension. Reporting was guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. The search yielded 10 eligible studies including 330 participants. The study designs included 5 RCTs, 1 cohort, 2 single-arm interventions, 1 retrospective, and 1 feasibility study. All studies showed some improvement in a physical and/or psychological outcome after the intervention period. One adverse event (nonserious) potentially related to the intervention was reported. Of the 5 RCTs, 2 were rated as high quality with low risk of bias using PEDro, and the majority of non-RCTs were rated as critical risk of bias by ROBINS-I. The results suggest that exercise and rehabilitation may be beneficial for various physical and psychological outcomes. Adequately powered and rigorous RCTs of exercise and rehabilitation interventions for people with EDS are needed.
Identifiants
pubmed: 35756986
doi: 10.1016/j.arrct.2022.100189
pii: S2590-1095(22)00014-3
pmc: PMC9214343
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
100189Informations de copyright
Crown Copyright © 2022 Published by Elsevier Inc. on behalf of American Congress of Rehabilitation Medicine.
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