Genotypic and phenotypic drug-resistance detection and prevalence of heteroresistance in patients with isoniazid- and multidrug-resistant tuberculosis in Ethiopia.
LPA
heteroresistance
isoniazid- and multidrug-resistant TB
Journal
IJID regions
ISSN: 2772-7076
Titre abrégé: IJID Reg
Pays: England
ID NLM: 9918418183106676
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
22
09
2021
revised:
28
11
2021
accepted:
19
12
2021
entrez:
27
6
2022
pubmed:
28
6
2022
medline:
28
6
2022
Statut:
epublish
Résumé
To assess the agreement between genotypic and phenotypic methods for detecting drug resistance, and examine the prevalence of heteroresistance among isoniazid (INH)- and multidrug/rifampicin-resistant (MDR/RR) TB. In total, 127 The sensitivity of LPA (compared with LJ DST) was 96% for any INH-resistant TB and 94% for any RR TB. The prevalence of heteroresistance among the 123. Some phenotypic drug resistances were not captured by LPA. The prevalence and percentage of resistant bacteria among heteroresistant TB highlight the importance of LPA for early detection of heteroresistant TB.
Identifiants
pubmed: 35757078
doi: 10.1016/j.ijregi.2021.12.007
pii: S2772-7076(21)00047-3
pmc: PMC9216396
doi:
Types de publication
Journal Article
Langues
eng
Pagination
149-153Subventions
Organisme : FIC NIH HHS
ID : D43 TW009127
Pays : United States
Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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