An Overview of Alphafold's Breakthrough.
AI
AlphaFold
AlphaFold2
CASP
deep learning
neural networks
protein folding
transformers
Journal
Frontiers in artificial intelligence
ISSN: 2624-8212
Titre abrégé: Front Artif Intell
Pays: Switzerland
ID NLM: 101770551
Informations de publication
Date de publication:
2022
2022
Historique:
received:
14
02
2022
accepted:
02
05
2022
entrez:
27
6
2022
pubmed:
28
6
2022
medline:
28
6
2022
Statut:
epublish
Résumé
This paper presents a short summary of the protein folding problem, what it is and why it is significant. Introduces the CASP competition and how accuracy is measured. Looks at different approaches for solving the problem followed by a review of the current breakthroughs in the field introduced by AlphaFold 1 and AlphaFold 2.
Identifiants
pubmed: 35757294
doi: 10.3389/frai.2022.875587
pmc: PMC9218062
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
875587Informations de copyright
Copyright © 2022 Marcu, Tăbîrcă and Tangney.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Nucleic Acids Res. 2005 Jun 10;33(10):3390-400
pubmed: 15951512
Biomolecules. 2020 Apr 17;10(4):
pubmed: 32316682
Bioinformatics. 2019 Nov 1;35(22):4862-4865
pubmed: 31116374
Proteins. 2004 Dec 1;57(4):702-10
pubmed: 15476259
Nucleic Acids Res. 2000 Jan 1;28(1):235-42
pubmed: 10592235
Protein Sci. 2021 Apr;30(4):728-734
pubmed: 33625752
Nat Rev Mol Cell Biol. 2019 Nov;20(11):681-697
pubmed: 31417196
Proteins. 2011;79 Suppl 10:1-5
pubmed: 21997831
Nature. 2020 Jan;577(7792):706-710
pubmed: 31942072
Proteins. 2014 Feb;82 Suppl 2:1-6
pubmed: 24344053
Biochimie. 2020 Aug;175:85-92
pubmed: 32417458
Proteins. 2016 Sep;84 Suppl 1:4-14
pubmed: 27171127
Proteins. 2018 Mar;86 Suppl 1:67-77
pubmed: 28845538
Cell Syst. 2019 Apr 24;8(4):292-301.e3
pubmed: 31005579
Biochem J. 1990 Aug 15;270(1):1-16
pubmed: 2204340
Nature. 2003 Dec 18;426(6968):900-4
pubmed: 14685251
Proteins. 2019 Dec;87(12):1011-1020
pubmed: 31589781