Treatment With Methotrexate Associated With Lipid Core Nanoparticles Prevents Aortic Dilation in a Murine Model of Marfan Syndrome.
Marfan syndrome
adenosine
aortic dilation
inflammation
lipid nanoparticle
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2022
2022
Historique:
received:
10
03
2022
accepted:
13
04
2022
entrez:
27
6
2022
pubmed:
28
6
2022
medline:
28
6
2022
Statut:
epublish
Résumé
In Marfan syndrome (MFS), dilation, dissection, and rupture of the aorta occur. Inflammation can be involved in the pathogenicity of aortic defects and can thus be a therapeutic target for MFS. Previously, we showed that the formulation of methotrexate (MTX) associated with lipid nanoparticles (LDE) has potent anti-inflammatory effects without toxicity. To investigate whether LDEMTX treatment can prevent the development of aortic lesions in the MFS murine model. MgΔloxPneo MFS (
Identifiants
pubmed: 35757348
doi: 10.3389/fcvm.2022.893774
pmc: PMC9226570
doi:
Types de publication
Journal Article
Langues
eng
Pagination
893774Informations de copyright
Copyright © 2022 Guido, Lopes, Albuquerque, Tavares, Jensen, Carvalho, Tavoni, Dias, Pereira, Laurindo and Maranhão.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Vasc Surg. 2008 Jan;47(1):166-72; discussion 172
pubmed: 18178469
Int J Cardiol. 2012 Jun 14;157(3):354-8
pubmed: 21239069
Anatol J Cardiol. 2018 Nov;20(5):289-295
pubmed: 30391968
PLoS One. 2014 Sep 19;9(9):e107221
pubmed: 25238161
Cardiol J. 2013;20(3):227-34
pubmed: 23788295
Mol Med Rep. 2017 Nov;16(5):7321-7328
pubmed: 28944857
PLoS One. 2019 Nov 14;14(11):e0224581
pubmed: 31725753
J Am Heart Assoc. 2014 Jan 21;3(1):e000476
pubmed: 24449804
PLoS One. 2012;7(3):e32963
pubmed: 22479353
Int J Mol Sci. 2018 Jul 21;19(7):
pubmed: 30037098
JAMA Cardiol. 2019 Jul 1;4(7):702-707
pubmed: 31066871
Am J Cardiol. 2020 Aug 1;128:101-106
pubmed: 32650901
Circulation. 2008 May 27;117(21):2802-13
pubmed: 18506019
Mol Ther Nucleic Acids. 2017 Dec 15;9:69-79
pubmed: 29246325
Cardiovasc Drugs Ther. 2013 Dec;27(6):531-9
pubmed: 24065615
Cardiovasc Pathol. 2018 Mar - Apr;33:62-69
pubmed: 29433109
Crit Care Med. 2012 Sep;40(9):2609-16
pubmed: 22732294
Cardiovasc Pathol. 2019 Jan - Feb;38:1-6
pubmed: 30359839
Pharmacol Ther. 2013 Oct;140(1):92-111
pubmed: 23764371
Meta Gene. 2014 Jan 14;2:96-105
pubmed: 25606393
Mol Pharm. 2022 Mar 7;19(3):843-852
pubmed: 35133169
Curr Top Dev Biol. 2006;75:93-123
pubmed: 16984811
Lipids. 2018 Feb;53(2):177-187
pubmed: 29394450
Ageing Res Rev. 2010 Jul;9(3):363-8
pubmed: 19772952
Cardiovasc Res. 2014 Oct 1;104(1):147-59
pubmed: 25139748
Lipids. 1997 Jun;32(6):627-33
pubmed: 9208392
Lipids. 1993 Aug;28(8):691-6
pubmed: 8377582
J Am Coll Cardiol. 2018 Oct 2;72(14):1613-1618
pubmed: 30261963
Int J Cardiol. 2015 Sep 1;194:7-12
pubmed: 26005802
J Anat. 1979 Oct;129(Pt 3):645-57
pubmed: 541247
Front Immunol. 2013 Apr 08;4:85
pubmed: 23580000
Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):960-72
pubmed: 25593132
J Pharm Pharm Sci. 2013;16(5):821-47
pubmed: 24393558
Nat Genet. 2003 Mar;33(3):407-11
pubmed: 12598898
J Cell Biol. 2007 Jan 29;176(3):355-67
pubmed: 17242066
Int J Nanomedicine. 2013;8:443-9
pubmed: 23439784
Circulation. 2001 Sep 18;104(12 Suppl 1):I282-7
pubmed: 11568070
Arterioscler Thromb Vasc Biol. 2001 Jul;21(7):1184-9
pubmed: 11451749
Herz. 2019 Apr;44(2):138-146
pubmed: 30747234
Blood. 1978 Dec;52(6):1099-114
pubmed: 214187
Arterioscler Thromb Vasc Biol. 2015 Jan;35(1):146-54
pubmed: 25359856
Circ Res. 2007 Aug 31;101(5):512-22
pubmed: 17641224
Prostaglandins Other Lipid Mediat. 2016 Mar;123:46-55
pubmed: 27163200
Braz J Med Biol Res. 2017 Aug 17;50(10):e6225
pubmed: 28832763
Int J Nanomedicine. 2011;6:2285-95
pubmed: 22072866
Biochim Biophys Acta Mol Basis Dis. 2020 Jan 1;1866(1):165587
pubmed: 31678158
Int J Nanomedicine. 2017 May 17;12:3767-3784
pubmed: 28553113
Braz J Med Biol Res. 1992;25(10):1003-7
pubmed: 1342820
J Biomech. 2016 Aug 16;49(12):2383-2389
pubmed: 26755343
Oxid Med Cell Longev. 2018 Mar 25;2018:3967213
pubmed: 29765495
Aorta (Stamford). 2013 Jun 01;1(1):5-12
pubmed: 26798667
N Engl J Med. 1990 Jul 19;323(3):152-9
pubmed: 2194127
Arthritis Rheumatol. 2019 Aug;71(8):1225-1231
pubmed: 30801994
Cancer Res. 1994 Sep 1;54(17):4660-6
pubmed: 8062260
PLoS One. 2010 Nov 30;5(11):e14136
pubmed: 21152435
J Struct Biol. 2014 Sep;187(3):242-253
pubmed: 25086405
PLoS One. 2016 Nov 8;11(11):e0164778
pubmed: 27824871
J Biol Chem. 2003 Jan 24;278(4):2750-7
pubmed: 12429738
Lancet. 2005 Dec 3;366(9501):1978-81
pubmed: 16325702
Am J Hum Genet. 2007 Oct;81(4):662-7
pubmed: 20529617
Circ Res. 2012 Jun 8;110(12):e92-e101
pubmed: 22550139