Psychoneuroendocrine protocol to comprehensively study sexually dimorphic cognition.
Gender diversity
Sex differences
Sex hormones
Sexual orientation
Sexually dimorphic cognition
Journal
Comprehensive psychoneuroendocrinology
ISSN: 2666-4976
Titre abrégé: Compr Psychoneuroendocrinol
Pays: England
ID NLM: 101774169
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
27
12
2020
revised:
15
03
2021
accepted:
15
03
2021
entrez:
27
6
2022
pubmed:
19
3
2021
medline:
19
3
2021
Statut:
epublish
Résumé
A large body of research provides evidence for sex differences in cognitive abilities. These sex differences stem from the interplay between biological sex (e.g., birth-assigned sex, sex hormones) and psychosocial gender (e.g., gender identity, gender-roles, sexual orientation). Literature remains rather mixed with regards to the magnitude of sex and gender effects on cognitive abilities and mental health. Growing evidence shows that sex hormone assessment combined with measures of psychosocial gender may be fundamental to comprehensively understand individual differences in sexually dimorphic cognitive abilities. This study protocol describes a sexually dimorphic cognitive battery to assess the influence of sex hormones on performance. In parallel, we aim to assess the inter-related effects that biological sex and psychosocial gender-based factors exert on cognition and mental health. Our projected sample includes 180 adult participants who are at least 18 years old. Sub-groups will be recruited based on birth-assigned sex, gender identity, and sexual orientation. Biological measures will be collected via salivary samples throughout testing to include sex hormones (testosterone, estradiol and progesterone) and stress hormones (cortisol). Demographic and psychosocial variables will be measured through self-report questionnaires. Participants will be required to complete eight classic cognitive tasks that assess a variety of cognitive domains in a 2-h testing session. Results from this study provides unique insights into the correlates of cognitive sex differences and gender diversity. This will give us solid ground to further investigate these influences in clinical populations in which sex hormones and cognitive functioning are often altered.
Sections du résumé
Background
UNASSIGNED
A large body of research provides evidence for sex differences in cognitive abilities. These sex differences stem from the interplay between biological sex (e.g., birth-assigned sex, sex hormones) and psychosocial gender (e.g., gender identity, gender-roles, sexual orientation). Literature remains rather mixed with regards to the magnitude of sex and gender effects on cognitive abilities and mental health. Growing evidence shows that sex hormone assessment combined with measures of psychosocial gender may be fundamental to comprehensively understand individual differences in sexually dimorphic cognitive abilities.
Objectives
UNASSIGNED
This study protocol describes a sexually dimorphic cognitive battery to assess the influence of sex hormones on performance. In parallel, we aim to assess the inter-related effects that biological sex and psychosocial gender-based factors exert on cognition and mental health.
Methods
UNASSIGNED
Our projected sample includes 180 adult participants who are at least 18 years old. Sub-groups will be recruited based on birth-assigned sex, gender identity, and sexual orientation. Biological measures will be collected via salivary samples throughout testing to include sex hormones (testosterone, estradiol and progesterone) and stress hormones (cortisol). Demographic and psychosocial variables will be measured through self-report questionnaires. Participants will be required to complete eight classic cognitive tasks that assess a variety of cognitive domains in a 2-h testing session.
Results and future directions
UNASSIGNED
Results from this study provides unique insights into the correlates of cognitive sex differences and gender diversity. This will give us solid ground to further investigate these influences in clinical populations in which sex hormones and cognitive functioning are often altered.
Identifiants
pubmed: 35757359
doi: 10.1016/j.cpnec.2021.100050
pii: S2666-4976(21)00024-2
pmc: PMC9216706
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100050Informations de copyright
Crown Copyright © 2021 Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
Arch Sex Behav. 2018 Nov;47(8):2149-2154
pubmed: 30182204
Nat Neurosci. 2015 Oct;18(10):1413-20
pubmed: 26404716
J Clin Exp Neuropsychol. 2009 Feb;31(2):219-33
pubmed: 19051129
Best Pract Res Clin Endocrinol Metab. 2007 Sep;21(3):431-44
pubmed: 17875490
Am Psychol. 2005 Sep;60(6):581-592
pubmed: 16173891
PLoS One. 2012;7(9):e46080
pubmed: 23029395
PLoS One. 2013;8(3):e57988
pubmed: 23516422
Arch Gynecol Obstet. 2008 Oct;278(4):299-307
pubmed: 18592262
Front Psychiatry. 2020 Jul 15;11:693
pubmed: 32760302
Nat Rev Neurol. 2018 Aug;14(8):457-469
pubmed: 29985474
Compr Physiol. 2016 Jun 13;6(3):1295-337
pubmed: 27347894
PLoS One. 2017 May 25;12(5):e0178043
pubmed: 28542498
Arch Clin Neuropsychol. 2017 Dec 01;32(8):972-979
pubmed: 28334345
Biol Reprod. 1991 Oct;45(4):523-32
pubmed: 1661182
J Int Neuropsychol Soc. 2006 Jul;12(4):502-9
pubmed: 16981602
J Sex Med. 2013 Aug;10(8):1969-77
pubmed: 23433223
Arch Clin Neuropsychol. 2006 Aug;21(5):413-20
pubmed: 16843636
Int J Psychophysiol. 2011 Mar;79(3):371-7
pubmed: 21185883
Neuropsychology. 2003 Apr;17(2):240-6
pubmed: 12803429
Brain Sci. 2020 Mar 27;10(4):
pubmed: 32230889
Mol Psychiatry. 2015 Mar;20(3):369-76
pubmed: 24888361
Brain Sci. 2018 Aug 28;8(9):
pubmed: 30154388
Clin Neuropsychol. 2009 Apr;23(3):501-9
pubmed: 18671154
Br J Clin Psychol. 2007 Mar;46(Pt 1):35-45
pubmed: 17472200
Neuropsychopharmacology. 2019 Jan;44(1):45-58
pubmed: 30111811
Science. 2006 Oct 20;314(5798):435
pubmed: 17053140
Neuropsychologia. 2004;42(6):782-90
pubmed: 15037056
Stress. 2017 Sep;20(5):476-494
pubmed: 28859530
Horm Behav. 2005 Mar;47(3):326-35
pubmed: 15708762
Arthritis Care Res (Hoboken). 2011 Nov;63 Suppl 11:S467-72
pubmed: 22588767
J Urol. 2003 Nov;170(5):1808-11
pubmed: 14532781
Psicothema. 2011 Nov;23(4):752-8
pubmed: 22047869
Percept Mot Skills. 1978 Oct;47(2):599-604
pubmed: 724398
J Appl Psychol. 1948 Jun;32(3):234-47
pubmed: 18867059
Andrologia. 1979 Jul-Aug;11(4):287-92
pubmed: 496034
Horm Behav. 2015 Aug;74:209-17
pubmed: 26122296
Arch Sex Behav. 2020 Feb;49(2):413-420
pubmed: 31975035
Arch Sex Behav. 2008 Feb;37(1):100-11
pubmed: 18074217
J Clin Exp Neuropsychol. 2002 Feb;24(1):107-14
pubmed: 11935429
Neuropsychologia. 2002;40(5):518-29
pubmed: 11749982
J Consult Clin Psychol. 1977 Apr;45(2):196-205
pubmed: 850004
Horm Behav. 2010 Jul;58(2):282-9
pubmed: 20226788
Physiol Behav. 2017 Oct 1;179:384-390
pubmed: 28694156
J Endocrinol Invest. 2005;28(3 Suppl):65-75
pubmed: 16044582
J Pers Assess. 1996 Dec;67(3):588-97
pubmed: 8991972
J Am Geriatr Soc. 2000 Jul;48(7):746-52
pubmed: 10894312
Psychoneuroendocrinology. 2016 Sep;71:180-8
pubmed: 27295182
Psychoneuroendocrinology. 2006 Jun;31(5):565-76
pubmed: 16487665
Sci Rep. 2018 Sep 12;8(1):13653
pubmed: 30209280
Psychol Bull. 1995 Jul;118(1):55-107
pubmed: 7644606
Psychoneuroendocrinology. 2020 Sep;119:104721
pubmed: 32512250
J Clin Psychol. 2011 Jan;67(1):99-110
pubmed: 20973032
Neuropsychol Rev. 2002 Jun;12(2):65-109
pubmed: 12371603
Psychon Bull Rev. 2011 Apr;18(2):267-77
pubmed: 21327340
Semin Reprod Med. 2011 Sep;29(5):383-90
pubmed: 22065325
Psychoneuroendocrinology. 2019 Nov;109:104373
pubmed: 31377558
J Neurosci Res. 2017 Jan 2;95(1-2):222-234
pubmed: 27870403
Emotion. 2016 Jun;16(4):515-23
pubmed: 26751627
Curr Psychiatry Rep. 2018 Oct 11;20(12):110
pubmed: 30306351
Neurosci Biobehav Rev. 2017 Dec;83:691-696
pubmed: 28698022
Sci Am. 1992 Sep;267(3):118-25
pubmed: 1298222
Cogn Behav Neurol. 2016 Sep;29(3):122-38
pubmed: 27662450
Horm Behav. 2009 May;55(5):570-8
pubmed: 19446073
J Sex Res. 2004 Feb;41(1):75-81
pubmed: 15216426
Br J Pharmacol. 2019 Nov;176(21):4119-4135
pubmed: 30658014
Psychoneuroendocrinology. 2005 Apr;30(3):225-42
pubmed: 15511597
Clin Neuropsychol. 2009 May;23(4):675-90
pubmed: 18923969
Nat Neurosci. 2015 May;18(5):690-7
pubmed: 25821913
J Exp Psychol Hum Percept Perform. 1988 Feb;14(1):3-11
pubmed: 2964504
Behav Brain Res. 2016 Feb 1;298(Pt B):78-90
pubmed: 26542812
Neuropsychology. 2003 Jan;17(1):25-31
pubmed: 12597070
Front Psychol. 2017 Mar 17;8:381
pubmed: 28367133
Psychoneuroendocrinology. 2012 Nov;37(11):1791-800
pubmed: 22520299
Science. 2005 Nov 4;310(5749):819-23
pubmed: 16272115
Clin Endocrinol (Oxf). 2009 Nov;71(5):607-23
pubmed: 19250266
Front Neurosci. 2015 Feb 17;9:12
pubmed: 25741229
Neuropsychology. 2001 Apr;15(2):165-73
pubmed: 11324860
Maturitas. 2013 Mar;74(3):208-12
pubmed: 23294933
J Int Neuropsychol Soc. 2005 Oct;11(6):727-36
pubmed: 16248908
Arch Sex Behav. 2017 Jul;46(5):1279-1294
pubmed: 28401317
Curr Opin Neurobiol. 2016 Jun;38:53-6
pubmed: 26953847
Psychoneuroendocrinology. 1991;16(1-3):189-201
pubmed: 1961839
Int J Aging Hum Dev. 1975;6(3):261-76
pubmed: 1213852
J Pers Soc Psychol. 1976 Jan;33(1):48-54
pubmed: 1018227
Dev Sci. 2018 Jul;21(4):e12613
pubmed: 29143410
Sports Health. 2013 Mar;5(2):143-9
pubmed: 24427382
Arch Clin Neuropsychol. 1996;11(4):329-38
pubmed: 14588937
Perspect Psychol Sci. 2013 May;8(3):340-57
pubmed: 26172976
Arch Neurol. 1978 Jun;35(6):364-7
pubmed: 655909
Front Neuroendocrinol. 2014 Aug;35(3):385-403
pubmed: 24434111
Horm Behav. 2008 Aug;54(2):286-93
pubmed: 18455727
Horm Behav. 2020 Jun;122:104754
pubmed: 32333931
Psychol Aging. 2016 Mar;31(2):166-75
pubmed: 26796792
Gen Comp Endocrinol. 2016 Aug 1;234:110-6
pubmed: 26851306
Psychoneuroendocrinology. 2018 May;91:115-122
pubmed: 29547742
Clin Chem. 2003 Aug;49(8):1381-95
pubmed: 12881456