Anhedonic- and anxiogenic-like behaviors and neurochemical alterations are abolished by a single administration of a selenium-containing compound in chronically stressed mice.
Antidepressant
Anxiolytic
Corticosterone
HPA axis
Organoselenium
PI3K/mTOR
Journal
Comprehensive psychoneuroendocrinology
ISSN: 2666-4976
Titre abrégé: Compr Psychoneuroendocrinol
Pays: England
ID NLM: 101774169
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
04
01
2021
revised:
02
03
2021
accepted:
22
03
2021
entrez:
27
6
2022
pubmed:
27
3
2021
medline:
27
3
2021
Statut:
epublish
Résumé
Despite the severity and the high prevalence of depression and anxiety and the efforts that have been done to improve their treatment, the available pharmacotherapy still has several limitations. Therefore, the investigation of novel agents and the characterization of the molecular signaling pathways underlying their effects are needed. The organoselenium compound 3-[(4-chlorophenyl)selanyl]-1-methyl-1
Identifiants
pubmed: 35757368
doi: 10.1016/j.cpnec.2021.100054
pii: S2666-4976(21)00028-X
pmc: PMC9216694
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100054Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
The authors declare that they have no conflict of interests.
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