Hepatic Stellate Cell-Immune Interactions in NASH.
NASH
fibrosis
hepatic stellate cells
immunity
inflammation
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2022
2022
Historique:
received:
01
02
2022
accepted:
29
04
2022
entrez:
27
6
2022
pubmed:
28
6
2022
medline:
29
6
2022
Statut:
epublish
Résumé
Nonalcoholic fatty liver disease (NAFLD) is the dominant cause of liver disease worldwide. Nonalcoholic steatohepatitis (NASH), a more aggressive presentation of NAFLD, is characterized by severe hepatocellular injury, inflammation, and fibrosis. Chronic inflammation and heightened immune cell activity have emerged as hallmark features of NASH and key drivers of fibrosis through the activation of hepatic stellate cells (HSCs). Recent advances in our understanding of the molecular and cellular pathways in NASH have highlighted extensive crosstalk between HSCs and hepatic immune populations that strongly influences disease activity. Here, we review these findings, emphasizing the roles of HSCs in liver immunity and inflammation, key cell-cell interactions, and exciting areas for future investigation.
Identifiants
pubmed: 35757404
doi: 10.3389/fendo.2022.867940
pmc: PMC9218059
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
867940Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK020541
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM062754
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK128289
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007280
Pays : United States
Informations de copyright
Copyright © 2022 Carter and Friedman.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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