Multiplex Serology for Measurement of IgG Antibodies Against Eleven Infectious Diseases in a National Serosurvey: Haiti 2014-2015.
Haiti
IgG detection
infectious disease
integrated serosurveillance
multiplex assay
seroprevalence
Journal
Frontiers in public health
ISSN: 2296-2565
Titre abrégé: Front Public Health
Pays: Switzerland
ID NLM: 101616579
Informations de publication
Date de publication:
2022
2022
Historique:
received:
15
03
2022
accepted:
18
05
2022
entrez:
27
6
2022
pubmed:
28
6
2022
medline:
29
6
2022
Statut:
epublish
Résumé
Integrated surveillance for multiple diseases can be an efficient use of resources and advantageous for national public health programs. Detection of IgG antibodies typically indicates previous exposure to a pathogen but can potentially also serve to assess active infection status. Serological multiplex bead assays have recently been developed to simultaneously evaluate exposure to multiple antigenic targets. Haiti is an island nation in the Caribbean region with multiple endemic infectious diseases, many of which have a paucity of data for population-level prevalence or exposure. A nationwide serosurvey occurred in Haiti from December 2014 to February 2015. Filter paper blood samples ( Different proportions of the Haiti study population were IgG seropositive to the different targets, with antigens from Multiplex serological assays can provide a wealth of information about population exposure to different infectious diseases. This current Haitian study included IgG targets for arboviral, parasitic, and bacterial infectious diseases representing multiple different modes of host transmission. Some of these infectious diseases had a paucity or complete absence of published serological studies in Haiti. Clear trends of disease burden with respect to age and location in Haiti can be used by national programs and partners for follow-up studies, resource allocation, and intervention planning.
Sections du résumé
Background
Integrated surveillance for multiple diseases can be an efficient use of resources and advantageous for national public health programs. Detection of IgG antibodies typically indicates previous exposure to a pathogen but can potentially also serve to assess active infection status. Serological multiplex bead assays have recently been developed to simultaneously evaluate exposure to multiple antigenic targets. Haiti is an island nation in the Caribbean region with multiple endemic infectious diseases, many of which have a paucity of data for population-level prevalence or exposure.
Methods
A nationwide serosurvey occurred in Haiti from December 2014 to February 2015. Filter paper blood samples (
Results
Different proportions of the Haiti study population were IgG seropositive to the different targets, with antigens from
Conclusions
Multiplex serological assays can provide a wealth of information about population exposure to different infectious diseases. This current Haitian study included IgG targets for arboviral, parasitic, and bacterial infectious diseases representing multiple different modes of host transmission. Some of these infectious diseases had a paucity or complete absence of published serological studies in Haiti. Clear trends of disease burden with respect to age and location in Haiti can be used by national programs and partners for follow-up studies, resource allocation, and intervention planning.
Identifiants
pubmed: 35757611
doi: 10.3389/fpubh.2022.897013
pmc: PMC9218545
doi:
Substances chimiques
Immunoglobulin G
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
897013Informations de copyright
Copyright © 2022 Chan, Martin, Mace, Jean, Stresman, Drakeley, Chang, Lemoine, Udhayakumar, Lammie, Priest and Rogier.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Lancet Infect Dis. 2018 Dec;18(12):e399-e407
pubmed: 29983342
Epidemiol Infect. 2015 Feb;143(3):618-30
pubmed: 25600668
PLoS Negl Trop Dis. 2012;6(12):e1941
pubmed: 23236534
Sci Rep. 2018 Dec 18;8(1):17920
pubmed: 30560920
PLoS Negl Trop Dis. 2012;6(7):e1746
pubmed: 22860146
PLoS Negl Trop Dis. 2019 Jan 28;13(1):e0007127
pubmed: 30689671
Am J Trop Med Hyg. 2017 Jun;96(6):1460-1467
pubmed: 28719280
Parasit Vectors. 2017 Jul 20;10(1):345
pubmed: 28728589
J Leukoc Biol. 2017 Jan;101(1):107-119
pubmed: 27780875
Mol Biochem Parasitol. 1990 Nov;43(1):97-106
pubmed: 2290448
BMJ. 2013 Jul 30;347:f4610
pubmed: 23900531
Mol Biochem Parasitol. 1996 Oct 1;80(2):137-47
pubmed: 8892291
Am J Trop Med Hyg. 2018 Jan;98(1):15-20
pubmed: 29165213
PeerJ. 2019 Jan 03;7:e6120
pubmed: 30627487
BMC Public Health. 2021 Jan 9;21(1):112
pubmed: 33422051
Int J Parasitol. 2012 Aug;42(9):797-800
pubmed: 22846784
Am J Trop Med Hyg. 2011 Jul;85(1):158-61
pubmed: 21734142
Clin Microbiol Infect. 2002 Oct;8(10):634-40
pubmed: 12390281
Mol Biochem Parasitol. 1995 Jul;73(1-2):231-9
pubmed: 8577331
PLoS Negl Trop Dis. 2018 Mar 9;12(3):e0006347
pubmed: 29522520
Mol Biochem Parasitol. 2002 Nov-Dec;125(1-2):73-81
pubmed: 12467975
Malar J. 2021 Sep 8;20(1):364
pubmed: 34493280
PLoS Negl Trop Dis. 2014 Jul 31;8(7):e3040
pubmed: 25078404
Clin Diagn Lab Immunol. 2005 Dec;12(12):1410-5
pubmed: 16339064
Parasit Vectors. 2021 Mar 17;14(1):160
pubmed: 33731176
Mol Biochem Parasitol. 1991 Nov;49(1):29-33
pubmed: 1775158
Am J Trop Med Hyg. 2017 Feb 8;96(2):312-318
pubmed: 27895279
PLoS One. 2018 Jul 2;13(7):e0199278
pubmed: 29966018
Elife. 2019 Aug 19;8:
pubmed: 31424386
PLoS Negl Trop Dis. 2015 Apr 10;9(4):e0003694
pubmed: 25860665
J Clin Microbiol. 1992 May;30(5):1127-33
pubmed: 1583109
Vaccine. 2004 Jan 26;22(5-6):611-7
pubmed: 14741152
Lancet. 2013 Jul 20;382(9888):209-22
pubmed: 23680352
Emerg Infect Dis. 2018 Jun;24(6):995-1001
pubmed: 29774861
Methods. 2006 Apr;38(4):317-23
pubmed: 16481199
Clin Chem. 1993 Apr;39(4):561-77
pubmed: 8472349
PLoS One. 2020 Dec 4;15(12):e0238010
pubmed: 33275613
Malar J. 2017 Jan 26;16(1):48
pubmed: 28126001
PLoS Negl Trop Dis. 2012;6(11):e1873
pubmed: 23133684
Infect Immun. 1997 Aug;65(8):3024-31
pubmed: 9234749
Bull World Health Organ. 2016 Nov 01;94(11):817-825A
pubmed: 27821884
J Clin Microbiol. 2016 May;54(5):1321-5
pubmed: 26962086
J Clin Microbiol. 1989 Jan;27(1):152-7
pubmed: 2643617
Malar J. 2016 Jul 22;15(1):376
pubmed: 27443992
Iran J Parasitol. 2014 Sep;9(3):336-41
pubmed: 25678917
Malar J. 2015 Nov 04;14:436
pubmed: 26537125
Ann Trop Med Parasitol. 2011 Dec;105(8):567-78
pubmed: 22325816
Diagn Microbiol Infect Dis. 2008 Nov;62(3):245-54
pubmed: 18703303
Nat Commun. 2018 Dec 21;9(1):5444
pubmed: 30575720
PLoS Negl Trop Dis. 2017 Feb 16;11(2):e0005387
pubmed: 28207792
Virology. 2003 Feb 1;306(1):170-80
pubmed: 12620809
Am J Trop Med Hyg. 2011 Aug;85(2):229-37
pubmed: 21813840
PLoS One. 2017 Aug 18;12(8):e0180845
pubmed: 28820883
PLoS Negl Trop Dis. 2012;6(12):e1930
pubmed: 23236529
J Microbiol. 2005 Aug;43(4):354-60
pubmed: 16145550
J Clin Microbiol. 2021 May 19;59(6):
pubmed: 33731416
Malar J. 2016 Oct 19;15(1):510
pubmed: 27756395
J Family Med Prim Care. 2013 Jan;2(1):33-6
pubmed: 24479040
PLoS Negl Trop Dis. 2016 May 03;10(5):e0004699
pubmed: 27136913
PLoS Negl Trop Dis. 2017 May 19;11(5):e0005616
pubmed: 28542223
PLoS Negl Trop Dis. 2013 May 09;7(5):e2165
pubmed: 23675541
Epidemiol Infect. 2018 May;146(7):888-894
pubmed: 29633686
J Clin Microbiol. 1999 May;37(5):1385-92
pubmed: 10203492
Am J Trop Med Hyg. 2017 Oct;97(4_Suppl):43-48
pubmed: 29064360
Mol Biochem Parasitol. 1993 Nov;62(1):143-6
pubmed: 8114819
Am J Trop Med Hyg. 2014 Apr;90(4):653-60
pubmed: 24591430