The influence of psychosocial and sexual wellbeing on quality of life in women with differences of sexual development.
Congenital adrenal hyperplasia
DSD
Psychosocial well-being
Quality of life
Turner syndrome
Journal
Comprehensive psychoneuroendocrinology
ISSN: 2666-4976
Titre abrégé: Compr Psychoneuroendocrinol
Pays: England
ID NLM: 101774169
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
13
04
2021
revised:
14
09
2021
accepted:
20
09
2021
entrez:
27
6
2022
pubmed:
28
6
2022
medline:
28
6
2022
Statut:
epublish
Résumé
Previous research indicating that women with differences of sexual development (DSD), namely women with Turner syndrome (TS), women with congenital adrenal hyperplasia (CAH), and women with XY-DSD, have an impaired psychosocial and sexual well-being and quality of life (QOL), was often limited by small samples and inadequate control groups (CGs). Only few studies analysed which psychosocial and sexual factors influence QOL in women with DSD and no study so far has examined whether the DSD-condition itself and the diagnostic group to which they belong moderate this influence. We compared 301 women with TS, 221 women with CAH and 142 women with XY-DSD with 603 non-DSD women regarding depression, anxiety, self-esteem, attention deficit hyperactivity disorder, autism, social participation, body acceptance, relationship status, sexual satisfaction and QOL. Furthermore, we investigated the influence of psychosocial and sexual well-being on QOL within and between diagnostic groups and examined whether the DSD-condition moderates the influence of psychosocial and sexual well-being on QOL. Women with DSD reported average psychosocial well-being and QOL; only women with CAH reported an impaired physical QOL. However, women with DSD were less satisfied with their body and had less often a partner than women in the CG. Women with CAH and XY-DSD were less satisfied with their sex life compared to women in the CG. Across groups, better health and lower depression scores predicted better QOL, whereas higher self-esteem especially predicted better QOL in women with DSD. The presence of DSD moderated the influence of psychosocial and sexual well-being on QOL, however, the specific diagnosis group mainly moderated the influence on physical QOL. We have learned that body and sexual satisfaction need further attention in women with DSD. To optimize their QOL, psychosocial well-being should be taken in account. The improvement of self-esteem seems particularly relevant for women with DSD, as this helps coping with having a variant of sexual development.
Sections du résumé
Background
UNASSIGNED
Previous research indicating that women with differences of sexual development (DSD), namely women with Turner syndrome (TS), women with congenital adrenal hyperplasia (CAH), and women with XY-DSD, have an impaired psychosocial and sexual well-being and quality of life (QOL), was often limited by small samples and inadequate control groups (CGs). Only few studies analysed which psychosocial and sexual factors influence QOL in women with DSD and no study so far has examined whether the DSD-condition itself and the diagnostic group to which they belong moderate this influence.
Methods
UNASSIGNED
We compared 301 women with TS, 221 women with CAH and 142 women with XY-DSD with 603 non-DSD women regarding depression, anxiety, self-esteem, attention deficit hyperactivity disorder, autism, social participation, body acceptance, relationship status, sexual satisfaction and QOL. Furthermore, we investigated the influence of psychosocial and sexual well-being on QOL within and between diagnostic groups and examined whether the DSD-condition moderates the influence of psychosocial and sexual well-being on QOL.
Results
UNASSIGNED
Women with DSD reported average psychosocial well-being and QOL; only women with CAH reported an impaired physical QOL. However, women with DSD were less satisfied with their body and had less often a partner than women in the CG. Women with CAH and XY-DSD were less satisfied with their sex life compared to women in the CG. Across groups, better health and lower depression scores predicted better QOL, whereas higher self-esteem especially predicted better QOL in women with DSD. The presence of DSD moderated the influence of psychosocial and sexual well-being on QOL, however, the specific diagnosis group mainly moderated the influence on physical QOL.
Conclusion
UNASSIGNED
We have learned that body and sexual satisfaction need further attention in women with DSD. To optimize their QOL, psychosocial well-being should be taken in account. The improvement of self-esteem seems particularly relevant for women with DSD, as this helps coping with having a variant of sexual development.
Identifiants
pubmed: 35757661
doi: 10.1016/j.cpnec.2021.100087
pii: S2666-4976(21)00061-8
pmc: PMC9216410
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100087Informations de copyright
© 2021 The Authors.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
Clin Endocrinol (Oxf). 2015 Feb;82(2):159-64
pubmed: 25040878
J Pediatr Urol. 2019 Aug;15(4):356-366
pubmed: 31133504
J Clin Endocrinol Metab. 2008 Feb;93(2):380-6
pubmed: 18029470
J Psychosom Res. 2015 Jul;79(1):76-84
pubmed: 25563666
J Adolesc Health. 2010 Nov;47(5):463-71
pubmed: 20970081
J Gen Intern Med. 1997 Jul;12(7):439-45
pubmed: 9229283
Pediatrics. 2006 Aug;118(2):e488-500
pubmed: 16882788
Arch Sex Behav. 2020 Feb;49(2):769-786
pubmed: 31598804
Psychol Med. 1998 May;28(3):551-8
pubmed: 9626712
Psychoneuroendocrinology. 2020 Mar;113:104548
pubmed: 31923612
J Public Health (Oxf). 2020 Nov 23;42(4):672-678
pubmed: 32657323
Lancet. 2017 Nov 11;390(10108):2194-2210
pubmed: 28576284
Psychol Med. 2005 Feb;35(2):245-56
pubmed: 15841682
Health Qual Life Outcomes. 2018 Apr 3;16(1):54
pubmed: 29615040
J Psychosom Res. 2016 Apr;83:57-64
pubmed: 27020078
BMC Endocr Disord. 2017 Aug 18;17(1):52
pubmed: 28821302
J Adolesc Health. 2007 Feb;40(2):192-4
pubmed: 17259066
J Pediatr Urol. 2021 Jun;17(3):353-365
pubmed: 33358555
J Dev Behav Pediatr. 1995 Apr;16(2):82-8
pubmed: 7790519
BMJ Paediatr Open. 2017 Oct 30;1(1):e000130
pubmed: 29637149
Arch Sex Behav. 1975 Nov;4(6):639-56
pubmed: 1212093
Psychosom Med. 2019 Sep;81(7):629-640
pubmed: 31232913
Acta Psychiatr Scand. 1983 Jun;67(6):361-70
pubmed: 6880820
J Clin Endocrinol Metab. 2005 Apr;90(4):1992-7
pubmed: 15644402
J Clin Endocrinol Metab. 2007 Jan;92(1):10-25
pubmed: 17047017
Eur J Endocrinol. 2006 Dec;155(6):877-85
pubmed: 17132758
J Clin Endocrinol Metab. 2012 Feb;97(2):577-88
pubmed: 22090272
Fertil Steril. 2010 Jun;94(1):105-13
pubmed: 19361791
J Sex Res. 2015;52(1):15-29
pubmed: 24144298
Clin Endocrinol (Oxf). 2015 Feb;82(2):274-9
pubmed: 25074426
Health Psychol. 2018 Apr;37(4):334-343
pubmed: 29608076
J Pediatr. 2006 Jan;148(1):95-101
pubmed: 16423606
Genet Couns. 1993;4(3):169-79
pubmed: 8267923
J Pediatr Endocrinol Metab. 2005 Jun;18(6):555-67
pubmed: 16042323
Horm Res. 2005;63(5):238-44
pubmed: 15900109
J Pediatr Endocrinol Metab. 2020 Feb 25;33(2):295-304
pubmed: 32004147
J Clin Endocrinol Metab. 2014 Aug;99(8):E1547-55
pubmed: 24878054
Am J Med Genet A. 2019 Nov;179(11):2196-2201
pubmed: 31460705
J Am Acad Child Adolesc Psychiatry. 2012 Feb;51(2):202-212.e7
pubmed: 22265366
Am J Med Genet A. 2010 May;152A(5):1136-56
pubmed: 20425818
J Sex Marital Ther. 2019;45(8):688-705
pubmed: 31034334
Eur J Pediatr. 2014 Jul;173(7):893-903
pubmed: 24469231