Actigraphic sleep and cortisol in middle childhood: A multivariate behavioral genetics model.
Actigraphy
Children
Cortisol
Heritability
Sleep
Wake episodes
Journal
Comprehensive psychoneuroendocrinology
ISSN: 2666-4976
Titre abrégé: Compr Psychoneuroendocrinol
Pays: England
ID NLM: 101774169
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
13
04
2021
revised:
09
08
2021
accepted:
11
10
2021
entrez:
27
6
2022
pubmed:
28
6
2022
medline:
28
6
2022
Statut:
epublish
Résumé
To date, behavioral genetic studies investigated either sleep or cortisol levels in middle childhood, but not both simultaneously. Therefore, a pertinent question is the degree to which genetic factors and environmental factor contribute to the correlation between sleep and cortisol levels. To address this question, we employed the classical twin design. We measured sleep in 6-9-year-old twins (N = 436 twin pairs, "Together Unique" study) over four consecutive nights using actigraphy, and we measured morning cortisol on two consecutive days. Sleep duration, sleep efficiency, and wake episodes were used as indicators of sleep. Morning cortisol level was used as cortisol indicator. A structural equation model was fitted to estimate the contribution of additive genetic effects (A), shared (common) environmental effects, (C) and unique environmental effects (E) to phenotypic variances and covariances. Age, cohort, and sex were included as covariates. The heritability of sleep duration, sleep efficiency, and wake episodes were 52%, 45%, and 55%, respectively. Common environmental factors played no significant role. High genetic correlations between sleep duration and sleep efficiency and high genetic correlations between sleep efficiency and wake episodes were found. Shared environmental (29%) and unique environmental factors (53%) explained the variance in morning cortisol levels. Because the sleep and cortisol measures were found to be uncorrelated, we did not consider genetic and environmental contributions to the association between the sleep and cortisol measures. Our findings indicate that sleep duration, sleep efficiency, and wake episodes in children are mostly impacted by genetic factors and by unique environmental factors (including measurement error).
Identifiants
pubmed: 35757668
doi: 10.1016/j.cpnec.2021.100094
pii: S2666-4976(21)00068-0
pmc: PMC9216557
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100094Informations de copyright
© 2021 The Authors.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
Soc Dev. 2018 Nov;27(4):967-983
pubmed: 30686863
Psychoneuroendocrinology. 2016 Jun;68:100-10
pubmed: 26963376
Psychoneuroendocrinology. 2015 Feb;52:297-301
pubmed: 25553389
J Abnorm Psychol. 2015 Aug;124(3):674-684
pubmed: 25938536
Psychoneuroendocrinology. 2003 Feb;28(2):121-37
pubmed: 12510008
Psychoneuroendocrinology. 2009 Nov;34(10):1437-48
pubmed: 19632788
Twin Res. 2000 Sep;3(3):134-41
pubmed: 11035485
Psychoneuroendocrinology. 2016 Apr;66:91-100
pubmed: 26799852
Nat Commun. 2019 Mar 7;10(1):1100
pubmed: 30846698
J Steroid Biochem Mol Biol. 1992 Dec;43(7):683-92
pubmed: 1472460
Neurosci Biobehav Rev. 2017 Dec;83:657-677
pubmed: 28864234
Trends Mol Med. 2004 Aug;10(8):409-15
pubmed: 15310462
Nat Genet. 2017 Feb;49(2):274-281
pubmed: 27992416
Eur J Clin Invest. 2014 May;44(5):493-500
pubmed: 24635035
Psychometrika. 2011 Apr 1;76(2):306-317
pubmed: 23258944
Genes Brain Behav. 2019 Jun;18(5):e12569
pubmed: 30916437
Curr Opin Psychiatry. 2014 Nov;27(6):453-9
pubmed: 25247458
Psychoneuroendocrinology. 1994;19(4):313-33
pubmed: 8047637
J Psychiatr Res. 2013 Nov;47(11):1809-14
pubmed: 24011863
Sleep. 2021 Jan 21;44(1):
pubmed: 32729904
J Sleep Res. 2013 Oct;22(5):519-26
pubmed: 23509903
Nat Commun. 2018 Dec 10;9(1):5257
pubmed: 30531941
Sci Adv. 2018 Jul 20;4(7):eaar2904
pubmed: 30035216
Behav Genet. 2003 Jul;33(4):421-33
pubmed: 14574141
J Clin Endocrinol Metab. 2020 Feb 1;105(2):
pubmed: 31608377
J Clin Endocrinol Metab. 2005 May;90(5):3106-14
pubmed: 15728214
Psychoneuroendocrinology. 2010 Jul;35(6):949-53
pubmed: 20079575
Dev Cogn Neurosci. 2018 Nov;34:42-52
pubmed: 29936358
BMC Psychol. 2016 Jun 06;4(1):33
pubmed: 27268415
Psychoneuroendocrinology. 2009 Feb;34(2):273-280
pubmed: 18938040
Sleep. 2013 Nov 01;36(11):1715-22
pubmed: 24179306
J Clin Endocrinol Metab. 2010 May;95(5):2254-61
pubmed: 20194713
Pharmacol Biochem Behav. 2001 Oct-Nov;70(2-3):305-10
pubmed: 11701201
Nat Rev Genet. 2002 Nov;3(11):872-82
pubmed: 12415317
J Biol Rhythms. 1999 Dec;14(6):557-68
pubmed: 10643753
Sleep. 2018 Mar 1;41(3):
pubmed: 29329461
Sci Rep. 2017 Sep 26;7(1):12340
pubmed: 28951572
J Allergy Clin Immunol. 2013 Nov;132(5):1033-44
pubmed: 24084075
Sleep Med. 2007 Dec;8 Suppl 3:27-33
pubmed: 18032104
J Child Psychol Psychiatry. 2019 Aug;60(8):857-865
pubmed: 30945287
Psychoneuroendocrinology. 2012 Feb;37(2):238-48
pubmed: 21742441
Health Psychol. 2008 Jan;27(1):26-33
pubmed: 18230010
J Adolesc Health. 2011 Jun;48(6):566-71
pubmed: 21575815
Sleep. 1994 Apr;17(3):201-7
pubmed: 7939118
Twin Res Hum Genet. 2011 Dec;14(6):553-61
pubmed: 22506311
Curr Opin Pharmacol. 2002 Feb;2(1):23-33
pubmed: 11786305
Sleep. 1999 Feb 1;22(1):95-103
pubmed: 9989370
Monogr Soc Res Child Dev. 2015 Mar;80(1):33-48
pubmed: 25704734
Sleep Health. 2015 Mar;1(1):40-43
pubmed: 29073412
BMC Pediatr. 2020 May 27;20(1):258
pubmed: 32460881
Obesity (Silver Spring). 2019 Apr;27(4):645-652
pubmed: 30816633
J Sleep Res. 2013 Oct;22(5):513-8
pubmed: 23509990