Pancreatic hamartoma: detection of harbouring NAB2::STAT6 fusion gene.
NAB2::STAT6 fusion gene
STAT6
pancreas
pancreatic hamartoma
Journal
Histopathology
ISSN: 1365-2559
Titre abrégé: Histopathology
Pays: England
ID NLM: 7704136
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
revised:
13
06
2022
received:
26
03
2022
accepted:
16
06
2022
pubmed:
28
6
2022
medline:
11
8
2022
entrez:
27
6
2022
Statut:
ppublish
Résumé
Hamartomas in the pancreas are rare and are often histologically and morphologically similar to solitary fibrous tumours (SFTs). We examined the differences between hamartomas and SFTs at the molecular level. METHODS AND RESULTS: Thirteen patients histopathologically diagnosed with pancreatic hamartoma were included in the study. We also performed STAT6 immunohistochemistry (IHC), which is used in the diagnosis of SFT. Furthermore, for the three cases in which RNA was extracted, reverse transcription polymerase chain reaction to search for NAB2::STAT6 fusions was used. Macroscopically, 13 patients had well-demarcated tumour lesions. Histologically, no islets of Langerhans were observed in the lesions, acinar tissue and ducts were unevenly distributed and elastic fibres were not observed around the ducts by Elastica van Gieson staining. One case contained a lipomatous hamartoma composed mainly of adipose tissue. Seven of the 13 cases demonstrated expression of STAT6 in the nuclei of intervening spindle cells. NAB2::STAT6 fusions were observed in two of the three cases in which RNA was extracted. These two cases also demonstrated STAT6 expression in spindle cells using STAT6 IHC. In one case of lipomatous hamartoma, we did not confirm NAB2::STAT6 fusion or STAT6 expression in STAT6 IHC. CONCLUSION: Of the 13 patients histopathologically diagnosed with hamartoma, two demonstrated NAB2::STAT6 fusions, suggesting the existence of pancreatic hamartomas with molecular-level components identical to those of SFT.
Substances chimiques
Biomarkers, Tumor
0
NAB2 protein, human
0
Recombinant Fusion Proteins
0
Repressor Proteins
0
STAT6 Transcription Factor
0
STAT6 protein, human
0
RNA
63231-63-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
319-328Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2022 John Wiley & Sons Ltd.
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