GPX4: old lessons, new features.

Animals Cell Death Ferroptosis Glutathione Peroxidase / metabolism Lipid Peroxidation / physiology Mammals / metabolism Phospholipid Hydroperoxide Glutathione Peroxidase
cell death ferroptosis redox biology

Journal

Biochemical Society transactions
ISSN: 1470-8752
Titre abrégé: Biochem Soc Trans
Pays: England
ID NLM: 7506897

Informations de publication

Date de publication:
30 06 2022
Historique:
received: 03 05 2022
revised: 02 06 2022
accepted: 07 06 2022
pubmed: 28 6 2022
medline: 2 7 2022
entrez: 27 6 2022
Statut: ppublish

Résumé

GPX4 is a selenocysteine-containing protein that plays an essential role in repairing peroxidised phospholipids. Its role in organismal homeostasis has been known for decades, and it has been reported to play a pivotal role in cell survival and mammalian embryonic development. In recent years, GPX4 has been associated with a cell death modality dubbed ferroptosis. The framing of this molecular pathway of cell death was essential for understanding the conditions that determine GPX4 dependency and ultimately to the process of lipid peroxidation. Since its discovery, ferroptosis has been gaining momentum as a promising target for yet-incurable diseases, including cancer and neurodegeneration. Given the current interest, in the present review, we provide newcomers in the field with an overview of the biology of GPX4 and cover some of its most recent discoveries.

Identifiants

DOI: 10.1042/BST20220682 PMID: 35758268
pubmed: 35758268
pii: 231481
doi: 10.1042/BST20220682
doi:

Substances chimiques

Phospholipid Hydroperoxide Glutathione Peroxidase EC 1.11.1.12
Glutathione Peroxidase EC 1.11.1.9

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1205-1213

Informations de copyright

© 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

Auteurs

Thamara Nishida Xavier da Silva (T)

Rudolf Virchow Zentrum, Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.

José Pedro Friedmann Angeli (JP)

Rudolf Virchow Zentrum, Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.

Irina Ingold (I)

Department of Medicine III, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › GPX4: old lessons, new features.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › GPX4: old lessons, new features.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Ferroptose › GPX4: old lessons, new features.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Sélénoprotéines › Glutathione peroxidase › GPX4: old lessons, new features.
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Peroxydation lipidique › GPX4: old lessons, new features.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › GPX4: old lessons, new features.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Sélénoprotéines › Glutathione peroxidase › Phospholipid hydroperoxide glutathione peroxidase › GPX4: old lessons, new features.