Repair of α-particle-induced DNA damage in peripheral blood mononuclear cells after internal ex vivo irradiation with
DSB damage
Irradiation
Repair
α-Particle
γ-H2AX
Journal
European journal of nuclear medicine and molecular imaging
ISSN: 1619-7089
Titre abrégé: Eur J Nucl Med Mol Imaging
Pays: Germany
ID NLM: 101140988
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
31
03
2022
accepted:
30
05
2022
pubmed:
28
6
2022
medline:
5
10
2022
entrez:
27
6
2022
Statut:
ppublish
Résumé
As α-emitters for radiopharmaceutical therapies are administered systemically by intravenous injection, blood will be irradiated by α-particles that induce clustered DNA double-strand breaks (DSBs). Here, we investigated the induction and repair of DSB damage in peripheral blood mononuclear cells (PBMCs) as a function of the absorbed dose to the blood following internal ex vivo irradiation with [ Blood samples of ten volunteers were irradiated by adding [ For 25 mGy, 50 mGy and 100 mGy, the numbers of α-tracks were significantly increased compared to baseline at all time points. Compared to the corresponding d-samples, the α-track frequency decreased significantly after 4 h and after 24 h. The repair rates R were (0.24 ± 0.05) h The results obtained suggest that induction and repair of the DSB damage depend on the absorbed dose to the blood. Repair rates were similar to what has been observed for irradiation with low linear energy transfer.
Identifiants
pubmed: 35759008
doi: 10.1007/s00259-022-05860-3
pii: 10.1007/s00259-022-05860-3
pmc: PMC9525426
doi:
Substances chimiques
Radiopharmaceuticals
0
DNA
9007-49-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3981-3988Informations de copyright
© 2022. The Author(s).
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