Nlp enhances biofilm formation by Yersinia pestis biovar microtus.

Animals Arvicolinae / metabolism Bacterial Proteins / genetics Biofilms Gene Expression Regulation, Bacterial Plague Yersinia pestis / metabolism
Biofilm Nlp Regulation Yersinia pestis

Journal

Microbial pathogenesis
ISSN: 1096-1208
Titre abrégé: Microb Pathog
Pays: England
ID NLM: 8606191

Informations de publication

Date de publication:
Aug 2022
Historique:
received: 24 02 2022
revised: 21 06 2022
accepted: 22 06 2022
pubmed: 28 6 2022
medline: 10 8 2022
entrez: 27 6 2022
Statut: ppublish

Résumé

Biofilms formed by Yersinia pestis are able to attach to and block flea's proventriculus, which stimulates the transmission of this pathogen from fleas to mammals. In this study, we found that Nlp (YP1143) enhanced biofilm formation by Y. pestis and had regulatory effects on biofilm-associated genes at the transcriptional level. Phenotypic assays, including colony morphology assay, crystal violet staining, and Caenorhabditis elegans biofilm assay, disclosed that Nlp strongly promoted biofilm formation by Y. pestis. Further gene regulation assays showed that Nlp stimulated the expression of hmsHFRS, hmsCDE and hmsB, while had no regulatory effect on the expression of hmsT and hmsP at the transcriptional level. These findings promoted us to gain more understanding of the complex regulatory circuits controlling biofilm formation by Y. pestis.

Identifiants

DOI: 10.1016/j.micpath.2022.105659 PMID: 35760284
pubmed: 35760284
pii: S0882-4010(22)00272-8
doi: 10.1016/j.micpath.2022.105659
pii:
doi:

Substances chimiques

Bacterial Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

105659

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Auteurs

Lei Liu (L)

Department of Transfusion Medicine, General Hospital of Central Theater Command, Wuhan, 430070, Hubei, China; The First School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China.

Yingyu He (Y)

The First School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China.

Huiying Yang (H)

State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China.

Wanbing Liu (W)

Department of Transfusion Medicine, General Hospital of Central Theater Command, Wuhan, 430070, Hubei, China.

Shangen Zheng (S)

Department of Transfusion Medicine, General Hospital of Central Theater Command, Wuhan, 430070, Hubei, China; The First School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China.

Yong Qi (Y)

Department of Transfusion Medicine, General Hospital of Central Theater Command, Wuhan, 430070, Hubei, China.

Dongsheng Zhou (D)

State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China.

Yiquan Zhang (Y)

Department of Clinical Laboratory, Nantong Third Hospital Affiliated to Nantong University, Nantong, 226006, Jiangsu, China. Electronic address: zhangyiquanq@163.com.

Zhe Yin (Z)

State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China. Electronic address: jerry9yin@163.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Nlp enhances biofilm formation by Yersinia...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Arvicolinae › Nlp enhances biofilm formation by Yersinia...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Nlp enhances biofilm formation by Yersinia...
questionsmedicales.fr › Phénomènes microbiologiques › Biofilms › Nlp enhances biofilm formation by Yersinia...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes bactériens › Nlp enhances biofilm formation by Yersinia...
questionsmedicales.fr › Infection › Maladies vectorielles › Peste › Nlp enhances biofilm formation by Yersinia...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Yersinia › Yersinia pestis › Nlp enhances biofilm formation by Yersinia...