Impact of weight loss on brain age: Improved brain health following bariatric surgery.
Bariatric surgery
Brain age
Voxel-based morphometry
Weight loss
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
01 10 2022
01 10 2022
Historique:
received:
10
12
2021
revised:
17
06
2022
accepted:
23
06
2022
pubmed:
28
6
2022
medline:
20
7
2022
entrez:
27
6
2022
Statut:
ppublish
Résumé
Individuals living with obesity tend to have increased brain age, reflecting poorer brain health likely due to grey and white matter atrophy related to obesity. However, it is unclear if older brain age associated with obesity can be reversed following weight loss and cardiometabolic health improvement. The aim of this study was to assess the impact of weight loss and cardiometabolic improvement following bariatric surgery on brain health, as measured by change in brain age estimated based on voxel-based morphometry (VBM) measurements. We used three distinct datasets to perform this study: 1) CamCAN dataset to train the brain age prediction model, 2) Human Connectome Project (HCP) dataset to investigate whether individuals with obesity have greater brain age than individuals with normal weight, and 3) pre-surgery, as well as 4, 12, and 24 month post-surgery data from participants (n = 87, age: 44.0 ± 9.2 years, BMI: 43.9 ± 4.2 kg/m
Identifiants
pubmed: 35760293
pii: S1053-8119(22)00532-8
doi: 10.1016/j.neuroimage.2022.119415
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
119415Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/H008217/1
Pays : United Kingdom
Organisme : Medical Research Council
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : U54 MH091657
Pays : United States
Organisme : CIHR
ID : TB2-138776
Pays : Canada
Informations de copyright
Copyright © 2022. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of Competing Interest A. T. and L. B. are recipients of research grant support from Johnson & Johnson Medical Companies and Medtronic for studies on bariatric surgery and the Research Chair in Bariatric and Metabolic Surgery at IUCPQ and Laval University. AT has received consulting fees from Bausch Health, Novo Nordisk and acts as a consultant for Biotwin. No author declared a conflict of interest relevant to the content of the manuscript.