Neurobiology of cancer - the role of cancer tissue innervation.
Neurobiológia nádorových chorôb - význam inervácie nádorového tkaniva.
cancer innervation
innervation
neurobiology of cancer
parasympathetic nerves
sensory nerves
sympathetic nerves
Journal
Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti
ISSN: 1802-5307
Titre abrégé: Klin Onkol
Pays: Czech Republic
ID NLM: 9425213
Informations de publication
Date de publication:
2022
2022
Historique:
entrez:
27
6
2022
pubmed:
28
6
2022
medline:
30
6
2022
Statut:
ppublish
Résumé
Experimental and clinical studies have shown that the nervous system also plays an important role in the processes of carcinogenesis, cancer cell proliferation, and metastasis. These studies, focused on the neurobio-logical aspects of cancer, elucidate the mechanisms and pathways by which the nervous system affects tumor macro- and microenvironment. The modulatory effect of the nervous system on the tumor microenvironment is significantly mediated by nerves that innervate cancer tissue. The innervation of cancer tissue is already an accepted fact, and several authors consider it to be another hallmark of cancer. The aim of this review article is to present a recent data about the role of innervation of cancer tissue, as well as to describe therapeutic consequences. Based on recent data, it can be concluded that the innervation of cancer tissue represents an important factor in the etiopathogenesis of cancer as well as a potential target for new therapeutic interventions in cancer patients.
Sections du résumé
BACKGROUND
BACKGROUND
Experimental and clinical studies have shown that the nervous system also plays an important role in the processes of carcinogenesis, cancer cell proliferation, and metastasis. These studies, focused on the neurobio-logical aspects of cancer, elucidate the mechanisms and pathways by which the nervous system affects tumor macro- and microenvironment. The modulatory effect of the nervous system on the tumor microenvironment is significantly mediated by nerves that innervate cancer tissue. The innervation of cancer tissue is already an accepted fact, and several authors consider it to be another hallmark of cancer.
PURPOSE
OBJECTIVE
The aim of this review article is to present a recent data about the role of innervation of cancer tissue, as well as to describe therapeutic consequences.
CONCLUSION
CONCLUSIONS
Based on recent data, it can be concluded that the innervation of cancer tissue represents an important factor in the etiopathogenesis of cancer as well as a potential target for new therapeutic interventions in cancer patients.
Identifiants
pubmed: 35760573
pii: 131143
doi: 10.48095/ccko2022208
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM